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- 저자 : Lijian Hui (검색결과 2 건)
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Lineage conversion of mouse fibroblasts to pancreatic α-cells
Lijian Hui,Liangliang Sun,Beige Jiang,Limei Li,Jin Cen,Xiaotao Chen,Zhaoyun Zhang,Qinghua Wang,Xin Cheng,Yongquan Shi,Lijian Hui 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
α-cells, which synthesize glucagon, also support β-cell survival and have the capacity to transdifferentiate into β-cells. However, the role of α-cells in pathological conditions and their putative clinical applications remain elusive due in large part to the lack of mature α-cells. Here, we present a new technique to generate functional α-like cells. α-like cells (iAlpha cells) were generated from mouse fibroblasts by transduction of transcription factors, including Hhex, Foxa3, Gata4, Pdx1 and Pax4, which induce α-cell-specific gene expression and glucagon secretion in response to KCl and Arg stimulation. The cell functions in vivo and in vitro were evaluated. Lineage-specific and functional-related gene expression was tested by realtime PCR, insulin tolerance test (ITT), glucose tolerance test (GTT), Ki67 and glucagon immunohistochemistry analysis were done in iAlpha cells transplanted nude mice. iAlpha cells possess α-cell function in vitro and alter blood glucose levels in vivo. Transplantation of iAlpha cells into nude mice resulted in insulin resistance and increased β-cell proliferation. Taken together, we present a novel strategy to generate functional α-like cells for the purposes of disease modeling and regenerative medicine.
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Manufacture and Performance of Textile-ramie Fiber Reinforced Anionic Polyamide 6 Composites
Hao Shi,Lijian Xia,Zonglei Guo,Abin Sun,Hui Wang,Ze Kan 한국섬유공학회 2019 Fibers and polymers Vol.20 No.8
A vacuum assistant resin infusion moulding (VARIM) was adopted to prepare a new-style and environmentalfriendly thermoplastic composite consisting of anionic polyamide-6 (APA-6) and textile-ramie fiber. However, the intensivepolymerization-inhibition and fiber-discoloration phenomena were found in the reactive processing. In order to overcomethese problems, two methods were used to suppress the reaction between the ramie fiber and APA-6, which are the surfacemodification of ramie fiber and a new initiator with a low activity. Finally, the inhibition and discoloration phenomena weresuppressed significantly, which overcame the major challenge during the preparation of ramie fiber reinforced APA-6composites by reactive processing. The composites showed a good polymerization during VARIM process. The tensilestrength and flexural modulus of the obtained composites were increased by 21 % and 26 % respectively compared with thatof pure APA-6. It is important to find that there were some interactions between APA-6 and ramie fiber, which produced agood interface characters. This work not only opens new avenues for the development of renewable composites, but alsofurther broadens the applications of the natural fibers.
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