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Recurrent Colonic Perforation in Geriatric Patients with Sigmoid Colostomy : Two Case Reports
Hyeonkyeong Kim,Kwang Ho Kim,Gyoung Tae Noh,Ho Seung Kim Ewha Womans University School of Medicine 2023 EMJ (Ewha medical journal) Vol.46 No.3
Recurrent colonic perforation in patients already having colostomy is extremely rare and only a few cases had been reported. Herein, we report 2 cases of recurrent colonic perforation at the proximal part of the colostomy in geriatric patients resulting from different causes, which might be caused by stercoral perforation and recurrent colonic ischemia, respectively. Based on our experience, surgeons should consider correcting chronic constipation even in patients who already have a colostomy. Additionally, transverse colostomy should be considered as a surgical treatment in patients with sigmoid colostomy for recurrent perforation due to colonic ischemia.
Minute Colon Perforation by a Nonabsorbable Suture Knot after Uterine Myomectomy
Hyeonkyeong Kim,Jinhoon Nam,Ryung-Ah Lee Ewha Womans University School of Medicine 2022 EMJ (Ewha medical journal) Vol.45 No.3
We report a rare case of suture material-related colon perforation. A 60-year-old woman visited clinics because of the nonspecific abdominal discomfort for several months. There were no specific medical history except previous laparoscopic myomectomy 15 years ago. Colonoscopy and abdomen-pelvis computed tomography revealed an unknown foreign body penetrating the sigmoid colon wall adjacent to the uterus. We performed laparoscopic exploration with foreign body removal and primary colon wall repair. The foreign body was identified as a non-absorbable suture material suggestive of used in previous myomectomy. With recent trends for minimally invasive procedures in the field of pelvic organ surgery, surgeons, especially those without sufficient training have to pay attention to selecting the proper surgical suture materials.
Epigenetic Regulation of Chondrocyte Catabolism and Anabolism in Osteoarthritis
Kim, Hyeonkyeong,Kang, Donghyun,Cho, Yongsik,Kim, Jin-Hong Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.8
Osteoarthritis (OA) is one of the most prevalent forms of joint disorder, associated with a tremendous socioeconomic burden worldwide. Various non-genetic and lifestyle-related factors such as aging and obesity have been recognized as major risk factors for OA, underscoring the potential role for epigenetic regulation in the pathogenesis of the disease. OA-associated epigenetic aberrations have been noted at the level of DNA methylation and histone modification in chondrocytes. These epigenetic regulations are implicated in driving an imbalance between the expression of catabolic and anabolic factors, leading eventually to osteoarthritic cartilage destruction. Cellular senescence and metabolic abnormalities driven by OA-associated risk factors appear to accompany epigenetic drifts in chondrocytes. Notably, molecular events associated with metabolic disorders influence epigenetic regulation in chondrocytes, supporting the notion that OA is a metabolic disease. Here, we review accumulating evidence supporting a role for epigenetics in the regulation of cartilage homeostasis and OA pathogenesis.