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- 저자 : Karalexi, Maria (검색결과 3 건)
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Achilleas Attilakos,Maria Paschalidou,Anastasia Garoufi,Maria Tsirouda,Anna Papadopoulou,Maria Karalexi,Argirios Dinopoulos 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.2
Background and Purpose Long-term treatment with some older antiepileptic drugs may lead to hyperhomocysteinemia. Levetiracetam (LEV) is a newer broad-spectrum antiepileptic agent whose effects on homocysteine concentrations remain unclear. The purpose of this study was to prospectively determine the short-term and long-term effects of LEV monotherapy on homocysteine metabolism in children with epilepsy. Methods The study population consisted of 32 children [18 females, 14 males; age 5.94±4.10 years (mean±SD), age range 1–15 years] who received LEV monotherapy for new-onset epilepsy. Serum folate, serum vitamin B12, and plasma total homocysteine (p-tHcy) were measured before and at 2 months (n=32), 6 months (n=25), and 12 months (n=18) of LEV monotherapy. Results p-tHcy was significantly decreased at 2 months of treatment (p=0.031). Furthermore, analysis of covariance showed statistically significant decreases in p-tHcy at 2 months (p=0.013) and 6 months (p=0.015) of LEV treatment after controlling for age, sex, body mass index, and LEV dose. There were no significant alterations in the other parameters during the study. The drug doses were 18.1±7.1, 20.1±9.2, and 21.2±11.8 mg/kg at 2, 6, and 12 months of LEV treatment, respectively. Conclusions In contrast with older antiepileptic drugs, long-term LEV monotherapy in children with epilepsy does not cause adverse alterations on homocysteine metabolism. Larger prospective studies are needed to definitively clarify whether LEV may be considered a safer alternative drug for preventing antiepileptic-drug-induced cardiovascular complications in adult life.
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Achilleas Attilakos,Lambros Fotis,Argirios Dinopoulos,Harris Alexopoulos,Aikaterini Vasileiou Theofilopoulou,Athanasios George Tzioufas,Sotiria Mastroyianni,Maria Karalexi,Anastasia Garoufi 대한신경과학회 2020 Journal of Clinical Neurology Vol.16 No.1
Background and Purpose The high prevalence of antiphospholipid antibodies (aPL) and antinuclear antibodies (ANA) in patients with epilepsy may be associated with either the disease itself or the antiepileptic treatment. The purpose of this prospective study was to determine the prevalence of aPL and ANA in children with idiopathic epilepsy before and during treatment with antiepileptic drugs. Methods aPL, including both anticardiolipin and anti-β2-glycoprotein I antibodies, and ANA statuses were determined in 40 healthy children, 30 children treated with sodium valproate (VPA) monotherapy, and 20 children treated with carbamazepine (CBZ) monotherapy before and at 6, 12, and 24 months after treatment initiation. Results Fifteen children (50%) in the VPA-treated group and 7 (35%) in the CBZ-treated group showed positivity for aPL before treatment initiation, compared with only 4 of the 40 controls. Nine children (30%) in the VPA-treated group and 4 (20%) in the CBZ-treated group showed positivity for ANA before treatment initiation, compared with only 2 of the 40 controls. The subgroup analysis found nonsignificant associations at the different time points regarding the positivity of all of the autoantibodies. Only patients treated with VPA had a significantly decreased risk of aPL positivity after 6 months of treatment. Conclusions The increased prevalence of autoantibodies in children with idiopathic epilepsy is strongly associated with the disease itself.
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Patterns of cellular phone use among young people in 12 countries: Implications for RF exposure
Langer, Chelsea E.,de Llobet, Patricia,Dalmau, Albert,Wiart, Joe,Goedhart, Geertje,Hours, Martine,Benke, Geza P.,Bouka, Evdoxia,Bruchim, Revital,Choi, Kyung-Hwa,Eng, Amanda,Ha, Mina,Karalexi, Maria,Ki Elsevier 2017 Environment international Vol.107 No.-
<P><B>Abstract</B></P> <P>Characterizing exposure to radiofrequency (RF) fields from wireless telecommunications technologies during childhood and adolescence is a research priority in investigating the health effects of RF. The Mobi-Expo study aimed to describe characteristics and determinants of cellular phone use in 534 young people (10–24years) in 12 countries. The study used a specifically designed software application installed on smartphones to collect data on the use of wireless telecommunications devices within this age group. The role of gender, age, maternal education, calendar period, and country was evaluated through multivariate models mutually adjusting for all variables. Call number and duration were higher among females compared to males (geometric mean (GM) ratio 1.17 and 1.42, respectively), among 20–24year olds compared to 10–14year olds (GM ratio 2.09 and 4.40, respectively), and among lowest compared to highest social classes (GM ratio 1.52 and 1.58, respectively). The number of SMS was higher in females (GM ratio 1.46) and the middle age group (15–19year olds: GM ratio 2.21 compared to 10–14year olds) and decreased over time. Data use was highest in the oldest age group, whereas Wi-Fi use was highest in the middle age group. Both data and Wi-Fi use increased over time. Large differences in the number and duration of calls, SMS, and data/Wi-Fi use were seen by country, with country and age accounting for up to 50% of the variance. Hands-free and laterality of use did not show significant differences by sex, age, education, study period, or country. Although limited by a convenience sample, these results provide valuable insights to the design, analysis, and interpretation of future epidemiological studies concerning the health effects of exposure resulting from cellular phone use in young people. In addition, the information provided by this research may be used to design strategies to minimize RF exposure.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Number and duration of calls varied by sex, age range, and socioeconomic status </LI> <LI> Laterality and hands-free use were less influenced by user characteristics </LI> <LI> Country of origin explained most of the variance in number and duration of calls, as well as SMS and data/Wi-Fi </LI> </UL> </P>
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