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Bond behavior between high volume fly ash concrete and steel rebars
Jiong-Feng Liang,Minghua Hu,Lian-Sheng Gu,Kai-Xi Xue 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.19 No.6
In this paper, 54 pull-out specimens and 36 cubic specimens with different replacement ratios of fly ash in the concrete (i.e., 0%, 20%, 30%, 40%, 50%, 60%) were fabricated to evaluate the bond at the interface between fly ash concrete and steel rebar. The results showed that the general shape of the bond-slip curve between fly ash concrete and steel rebar was similar to that for the normal concrete and steel rebar. The bond strength between fly ash concrete and the steel rebar was closer to each other at the same rebar diameter, irrespective of the fly ash replacement percentage. On the basis of a regression analysis of the experimental data, a revised bond strength mode and bond-slip relationship model were proposed to predict the bond-slip behaviour of high volume fly ash concrete and steel rebar.
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Expression and Prognostic Role of MEKK3 and pERK in Patients with Renal Clear Cell Carcinoma
Chen, Qi,Lu, Hong-sheng,Gan, Mei-fu,Chen, Lan-xi,He, Kai,Fan, Guang-min,Cao, Xue-quan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6
Mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 3 (MEKK3) is an important serine/threonine protein kinase and a member of the MAPK family. MEKK3 can effectively activate the MEK/ERK signaling pathway and promote an autocrine growth loop critical for tumor genesis, cell proliferation, terminal differentiation, apoptosis and survival. To explore the relationship between MEKK3 and cell apoptosis, clinicopathology and prognosis, we characterize the expression of MEKK3, pERK and FoxP3 in the renal clear cell carcinoma (RCCC). Protein expression was detected by tissue microarray and immunochemistry in 46 cases of RCCC and 28 control cases. Expression levels of CD3+,CD3+CD4+,CD3+CD8+,CD4+CD25+, CD4+CD25+ FoxP3+ were assessed by flow cytometry and analyzed for their association with pathological factors, correlation and prognosis in RCCC. Expression of MEKK3, pERK and FoxP3 was significantly up-regulated in RCCC as compared to control levels (p<0.01), associated with pathological grade (p<0.05)and clinical stage (p<0.05). CD4+CD25+ Foxp3+ Treg cells were also significantly increased in RCCC patients (p<0.05). Cox multivariate regression analysis showed that MEKK3, pERK expression and patholigical stage were independent prognostic factors in patients with RCCC (p<0.05). MEKK3 can be used as an important marker of early diagnosis and prognostic evaluation in RCCC. It may be associated with imbalance of anti-tumor immunity and overexpression of pERK. Expression of MEKK3 and pERK are significantly increased in RCCC, with protein expression and clinical stage acting as independent prognostic factors.
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