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- 저자 : K. Pandima Devi (검색결과 1 건)
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K. Pandima Devi,R. Sakthivel,S. Arif Nisha,N. Suganthy,S. Karutha Pandian 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.3
Eugenol, a member of the phenylpropanoidsclass of chemical compounds, is a clear to pale yellow oilyliquid extracted from certain essential oils especially fromclove oil, nutmeg, cinnamon, and bay leaf. The antibacterialactivity of eugenol and its mechanism of bactericidalaction against Proteus mirabilis were evaluated. Treatmentwith eugenol at their minimum inhibitory concentration[0.125 % (v/v)] and minimum bactericidal concentration[0.25 % (v/v)] reduced the viability and resulted in completeinhibition of P. mirabilis. A strong bactericidal effecton P. mirabilis was also evident, as eugenol inactivated thebacterial population within 30 min exposure. Chemoattractantproperty and the observance of highest antibacterialactivity at alkaline pH suggest that eugenol can workmore effectively when given in vivo. Eugenol inhibits thevirulence factors produced by P. mirabilis as observed byswimming motility, swarming behavior and urease activity. It interacts with cellular membrane of P. mirabilis andmakes it highly permeable, forming nonspecific pores onplasma membrane, which in turn directs the release of260 nm absorbing materials and uptake of more crystalviolet from the medium into the cells. SDS–polyacrylamidegel, scanning electron microscopy and Fourier transforminfrared analysis further proves the disruptive action ofeugenol on the plasma membrane of P. mirabilis. Thefindings reveal that eugenol shows an excellent bactericidalactivity against P. mirabilis by altering the integrity of cellmembrane.
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