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Epidemiology and Clinical Management of Pulmonary Hypertension in Children
Hongfang Jin,Jinyan Yang,Qingyou Zhang,Junbao Du 대한심장학회 2012 Korean Circulation Journal Vol.42 No.8
Pulmonary hypertension (PH) is a clinical hemodynamic syndrome characterized by increased pulmonary artery pressure and pulmonary vascular resistance. It can cause right ventricular failure, and even death. Pediatric PH is not very common, but is a greatly hazardous dis-ease that leads to a high mortality rate. Therefore, many registry organizations have been established in the world to strengthen the study of diagnosis and treatment of the disease, and improve the understanding of pediatric PH. This article reviewed recently published re-searches, as well as presented a comprehensive understanding of PH, including definition, classification, epidemiology, prognosis and treatment.
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Transcription factor Sp1 is necessary and functional in regulating expression of oncogene ZNF703
Xiaolin Liao,Yongjie Lu,Junbao Yang,Tao Kuang,Lilin Jiang,Yanjun Wang,Huiqun Kang,Bo Jiang,Xiaoli Zhou,Sheng He 한국유전학회 2017 Genes & Genomics Vol.39 No.10
Zinc finger protein 703 (ZNF703) is a putative oncogene in patients with the luminal B molecular subtype of breast cancer. Although the exact function of ZNF703 protein remains largely unknown, its expression and regulation have been implicated in several physiological and pathological processes. In the current study, for the first time, we identified and characterized the human ZNF703 gene promoter region. As a means of characterizing the transcription elements required for expression of ZNF703 protein at different stages, we cloned the promoter region of ZNF703 then created chimeric reporter plasmids for use in luciferase assays. A progressive deletion analysis of the ZNF703 gene’s 5′ and 3′ -flanking regions revealed that the core promoter is located in a 256-bp region ranging from nt-539 to nt-283. Next, we examined the effects of sitespecific mutations and treatment with mithramycin A to identify the functional Sp1 binding site, which was found to be located in a 447 bp region that ranged from nt-509 to nt-76, displayed the characteristics of a CpG island, and overlapped with the promoter region. In conclusion, our data suggest that ZNF703 transcription is regulated by transcription factor Sp1. This finding should facilitate future studies of the mechanism which regulates expression of this important gene.
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