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- 저자 : Jovanka M. Filipović (검색결과 1 건)
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pH-Sensitive Hydrogels Based on (Meth)Acrylates and Itaconic Acid
Simonida Lj. Tomić,Marija M. Babić,Katarina M. Antić,Jovana S. Jovašević Vuković,Neda B. Malešić,Jovanka M. Filipović 한국고분자학회 2014 Macromolecular Research Vol.22 No.11
Novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and different poly(alkylene glycol) (meth)acrylates (PAGM) (P(HEMA/IA/PAGM)) were synthesized. We investigated the influenceof different PAGM components, with acrylic or methacrylic acid residues in the main chain and ethylene glycol (EG)and/or propylene glycol (PG) units in pendant chains of varying length, on the nature and inherent properties ofP(HEMA/IA/PAGM) copolymeric hydrogels. Swelling studies revealed pH sensitive behavior of P(HEMA/IA/PAGM)samples. Hydrogel structure and morphology were characterized by Fourier transform infrared (FTIR) spectroscopyand scanning electron microscopy (SEM), which confirmed their chemical structure and differences in pore size. The shear modulus values for P(HEMA/IA/PAGM) hydrogels were close to that of PHEMA, but slightly lower thanthe value for P(HEMA/IA). Cephalexin (CEX) drug release profiles from P(HEMA/IA/PAGM) samples showed amarked dependence on the PAGM component. The presence of IA also influenced the release rate of CEX, leadingto a faster release when IA was combined with the more hydrophilic PAGM component. An in vitro assay of P(HEMA/IA/PAGM) cytotoxicity showed good cell viability. The results obtained indicate that P(HEMA/IA/PAGM) hydrogelproperties were significantly dependent on the PAGM component, meaning that the type of side chains can be usedto tune the characteristics of such biomaterials. These properties make P(HEMA/IA/PAGM) copolymeric hydrogelsapplicable in biomedical and biotechnological fields and controlled drug delivery.
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