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OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin
Han, Jonghee,Jung, Sunmin,Jang, Jiyeon,Kam, Tae-In,Choi, Hyunwoo,Kim, Byung-Ju,Nah, Jihoon,Jo, Dong-Gyu,Nakagawa, Toshiyuki,Nishimura, Masaki,Jung, Yong-Keun Springer-Verlag 2014 Cellular and molecular life sciences Vol.71 No.13
Comparative Evaluation of Voice Activity Detectors in Single Microphone Noise Reduction Algorithms
Jonghee Han,김인영,Dongwook Kim,육순현,남경원,장동표,Sang Min Lee,Sung Hwa Hong 대한의용생체공학회 2012 Biomedical Engineering Letters (BMEL) Vol.2 No.4
Purpose Voice activity detection (VAD) is significantly associated with the performance of single microphone noise reduction algorithms. In this study, the cause and extent of the VAD effect on noise reduction performance were analyzed by comparing conventional VAD algorithms with ideal VAD. Methods A Wiener filter and logMMSE estimator employing various VAD algorithms were implemented using Simulink models and simulated with various 30-second speeches mixed with different noises at -5, 0 and 5 dB SNR. In addition, a noise estimation method not using VAD was also compared to facilitate a more extensive evaluation. The VAD and noise estimation accuracy were analyzed and objective speech quality measures such as fwSNR, PESQ and LLR were calculated. Results Statistical analysis showed that the noise reduction performance using ideal VAD was significantly better than using conventional methods, the performance of which is dependent on noise types and SNR conditions. Conclusions Consequently, there is still much room to improve VAD algorithms to have a high non-speech hit rate and low non-speech false alarm rate for better noise reduction performance in all noisy circumstances.
( Jonghee Han ),( Su Young Yoon ),( Junepill Seok ),( Jin Young Lee ),( Jin Suk Lee ),( Jin Bong Ye ),( Younghoon Sul ),( Seheon Kim ),( Hong Rye Kim ) 대한외상학회 2023 大韓外傷學會誌 Vol.36 No.4
Purpose: In this study, we aimed to compare the characteristics of patients with trauma by age group in a single center in Korea to identify the clinical characteristics and analyze the risk factors affecting mortality. Methods: Patients aged ≥18 years who visited the Chungbuk National University Hospital Regional Trauma Center between January 2016 and December 2022 were included. The accident mechanism, severity of the injury, and outcomes were compared by classifying the patients into group A (18-64 years), group B (65-79 years), and group C (≥80 years). In addition, logistic regression analysis was performed to identify factors affecting death. Results: The most common injury mechanism was traffic accidents in group A (40.9%) and slipping in group B (37.0%) and group C (56.2%). Although group A had the highest intensive care unit admission rate (38.0%), group C had the highest mortality rate (9.5%). In the regression analysis, 3 to 8 points on the Glasgow Coma Scale had the highest odds ratio for mortality, and red blood cell transfusion within 24 hours, intensive care unit admission, age, and Injury Severity Score were the predictors of death. Conclusions: For patients with trauma, the mechanism, injured body region, and severity of injury differed among the age groups. The high mortality rate of elderly patients suggests the need for different treatment approaches for trauma patients according to age. Identifying factors affecting clinical patterns and mortality according to age groups can help improve the prognosis of trauma patients in the future.
Enhanced Hard-magnetic Properties of Rare Earth-free L1<SUB>0</SUB>-FeNi Phase in FeNiPC Alloys
Jonghee Han,Jin-Yoo Suh,Hyunsol Son,Haein Choi-Yim 한국자기학회 2021 Journal of Magnetics Vol.26 No.4
In this study, FeNi-based amorphous alloys having crystallization temperature (Tx) close to FeNi order-disorder transition temperature were developed. Through an extended annealing process at around the crystallization temperature, an ordered phase, L10-FeNi, was formed. Structural characterizations of annealed ribbons confirmed the formation of L10-FeNi phase through observation of a weak superlattice peak. Measured coercivity (Hc) also indicated formation of the ordered L10-FeNi phase, which increased up to 744 Oe after the annealing process.