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Preclinical development of a humanized neutralizing antibody targeting HGF
Kim, Hyori,Hong, Sung Hee,Kim, Jung Yong,Kim, In-Chull,Park, Young-Whan,Lee, Song-Jae,Song, Seong-Won,Kim, Jung Ju,Park, Gunwoo,Kim, Tae Min,Kim, Yun-Hee,Park, Jong Bae,Chung, Junho,Kim, In-Hoo Nature Publishing Group 2017 Experimental and molecular medicine Vol.49 No.3
<P>Hepatocyte growth factor (HGF) and its receptor, cMET, play critical roles in cell proliferation, angiogenesis and invasion in a wide variety of cancers. We therefore examined the anti-tumor activity of the humanized monoclonal anti-HGF antibody, YYB-101, in nude mice bearing human glioblastoma xenografts as a single agent or in combination with temozolomide. HGF neutralization, The extracellular signal-related kinases 1 and 2 (ERK1/2) phosphorylation, and HGF-induced scattering were assessed in HGF-expressing cell lines treated with YYB-101. To support clinical development, we also evaluated the preclinical pharmacokinetics and toxicokinetics in cynomolgus monkeys, and human and cynomolgus monkey tissue was stained with YYB-101 to test tissue cross-reactivity. We found that YYB-101 inhibited cMET activation <I>in vitro</I> and suppressed tumor growth in the orthotopic mouse model of human glioblastoma. Combination treatment with YYB-101 and temozolomide decreased tumor growth and increased overall survival compared with the effects of either agent alone. Five cancer-related genes (TMEM119, FST, RSPO3, ROS1 and NBL1) were overexpressed in YYB-101-treated mice that showed tumor regrowth. In the tissue cross-reactivity assay, critical cross-reactivity was not observed. The terminal elimination half-life was 21.7 days. Taken together, the <I>in vitro</I> and <I>in vivo</I> data demonstrated the anti-tumor efficacy of YYB-101, which appeared to be mediated by blocking the HGF/cMET interaction. The preclinical pharmacokinetics, toxicokinetics and tissue cross-reactivity data support the clinical development of YYB-101 for advanced cancer.</P>
Periventricular white matter hyperintensities and the risk of dementia: a CREDOS study
Kim, Sangha,Choi, Seong Hye,Lee, Young Min,Kim, Min Ji,Kim, Young Don,Kim, Jin Young,Park, Jin Hong,Myung, Woojae,Na, Hae Ri,Han, Hyun Jeong,Shim, Yong S.,Kim, Jong Hun,Yoon, Soo Jin,Kim, Sang Yun,Kim Cambridge University Press 2015 INTERNATIONAL PSYCHOGERIATRICS - Vol.27 No.12
<B>ABSTRACT</B><B>Background:</B><P>Cerebral white matter hyperintensities (WMH) are prevalent incident findings on brain MRI scans among elderly people and have been consistently implicated in cognitive dysfunction. However, differential roles of WMH by region in cognitive function are still unclear. The aim of this study was to ascertain the differential role of regional WMH in predicting progression from mild cognitive impairment (MCI) to different subtypes of dementia.</P><B>Methods:</B><P>Participants were recruited from the Clinical Research Center for Dementia of South Korea (CREDOS) study. A total of 622 participants with MCI diagnoses at baseline and follow-up evaluations were included for the analysis. Initial MRI scans were rated for WMH on a visual rating scale developed for the CREDOS. Differential effects of regional WMH in predicting incident dementia were evaluated using the Cox proportional hazards model.</P><B>Results:</B><P>Of the 622 participants with MCI at baseline, 139 patients (22.3%) converted to all-cause dementia over a median of 14.3 (range 6.0-36.5) months. Severe periventricular WMH (PWMH) predicted incident all-cause dementia (Hazard ratio (HR) 2.22; 95% confidence interval (CI) 1.43-3.43) and Alzheimer's disease (AD) (HR 1.86; 95% CI 1.12-3.07). Subcortical vascular dementia (SVD) was predicted by both PWMH (HR 16.14; 95% CI 1.97-132.06) and DWMH (HR 8.77; 95% CI 1.77-43.49) in more severe form (≥ 10 mm).</P><B>Conclusions:</B><P>WMH differentially predict dementia by region and severity. Our findings suggest that PWMH may play an independent role in the pathogenesis of dementia, especially in AD.</P>
Synergistic effects of longitudinal amyloid and vascular changes on lobar microbleeds
Kim, Yeo Jin,Kim, Hee Jin,Park, Jae-Hyun,Kim, Seonwoo,Woo, Sook-Young,Kwak, Ki-Chang,Lee, Jong Min,Jung, Na-Yeon,Kim, Jae Seung,Choe, Yearn Seong,Lee, Kyung-Han,Moon, Seung Hwan,Lee, Jae-Hong,Kim, Yun Ovid Technologies (Wolters Kluwer) - American Acad 2016 Neurology Vol.87 No.15
<P>Conclusions: Our findings suggest that amyloid-related pathology and hCSVD have synergistic effects on the progression of lobar microbleeds, providing new clinical insight into the interaction between amyloid burden and hCSVD on CMB progression and cognitive decline with implications for developing effective prevention strategies.</P>
Kim, Jong-Bae,Kim, Hong,Jin, Hyun-Seok,Kim, Young-Sam,Kim, Keun-Sung,Kang, Yun-Sook,Park, Jong-Seok,Lee, Dong-Ha,Woo, Gun-Jo,Kim, Chang-Min 대한의생명과학회 2001 Journal of biomedical laboratory sciences Vol.7 No.2
Many Staphylococcus aureus stains produce enterotoxins causing food poisoning. Staphylococcal enterotoxins are classified by serological criteria into five major groups - subtype A to E. It is difficult, time-consuming, and expensive to detect staphylococcal enterotoxins in the clinical laboratory. In this study, we tried to detect the enterotoxin genes of Staphylococcus aureus strains isolated from clinical specimens and Kimbap - rice rolled in a sheet of laver - using multiplex PCR technique. A total of 77 strains of Staphylococcus aureus from clinical specimens and 78 strains from Kimbap were isolated. Among clinical isolates of S. aureus, 60 strains (78.0%) were identified as producing enterotoxins. A total of 55 strains (91.6%) in the 60 staphylococcal enterotoxin producing strains were enterotoxul subtype C. In case of kimbap, 43 (55.1%) strains were detected to produce enterotoxins and 39 (90.6%) enterotoxin producing strains were subtype A.
Kim, Dohun,Kim, Hong Kwan,Kim, Seok-Hyung,Lee, Ho Yun,Cho, Jong Ho,Choi, Yong Soo,Kim, Kwhanmien,Kim, Jhingook,Zo, Jae Ill,Shim, Young Mog AME Publishing Company 2018 Journal of thoracic disease Vol.10 No.1
<P>Conclusions: Histologic subtype according to the IASLC/ATS/ERS classification and TDR both correlated with pathologic invasiveness and predicted survival in patients with lung adenocarcinoma with GGO.</P>
Highly Stable Thin-Film Transistors Based on Indium Oxynitride Semiconductor
Kim, Hyoung-Do,Kim, Jong Heon,Park, Kyung,Park, Yun Chang,Kim, Sunkook,Kim, Yong Joo,Park, Jozeph,Kim, Hyun-Suk American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.18
<P>In this study, the properties of indium oxynitride (InON) semiconductor films grown by reactive radio frequency sputtering were examined both experimentally and theoretically. Also, thin-film transistors (TFTs) incorporating InON as the active layer were evaluated for the first time. It is found that InON films exhibit high stability upon prolonged exposure to air and the corresponding TFTs are more stable when subjected to negative bias illumination stress, compared to devices based on indium oxide (In<SUB>2</SUB>O<SUB>3</SUB>) or zinc oxynitride (ZnON) semiconductors. X-ray photoelectron spectroscopy analyses of the oxygen 1s peaks suggest that as nitrogen is incorporated into In<SUB>2</SUB>O<SUB>3</SUB> to form InON, the relative fraction of oxygen-deficient regions decreases significantly, which is most likely to occur by having the valence band maximum shifted up. Density functional theory calculations indicate that the formation energy of InN is much lower than Zn<SUB>3</SUB>N<SUB>2</SUB>, thus accounting for the higher stability of InON compared to ZnON in air.</P> [FIG OMISSION]</BR>
State Indicator of Water Quality for Surface Water and Groundwater in Agriculture
Kim, Min-Kyeong,Jung, Goo-Bok,Ro, An-Sung,Choi, Seung-Chul,Choi, Won-Il,Kim, Eun-Jeong,Lee, Jong-Eun,Yun, Yeo-Uk,Kim, Kab-Cheol,Ko, Do-Young,Kim, Byeong-Ho,Kim, Hyeon-Ji,Park, Sang-Jo,Lee, Seong-Tae,H 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.5
Indicators of environmental conditions qualitatively and quantitatively describe the state of the environment and natural resources, and the OECD (Organization for Economic Cooperation and Development) has initiated and suggested AEIs (Agri-Environmental Indicators) to assess trends over time of the effects of agriculture on the environment and the effectiveness and efficiency of agricultural and environmental policy measures since 1990's. This study aims to develop the state indicators of water quality for agricultural water, surface and groundwater, to evaluate the environmental impacts of agricultural activities and policies by qualifying the environmental levels of a nation. Status indicators were calculated according to the agricultural water quality standards of OECD and Korea, and their trends were analyzed over time. Particularly, nitrate ($NO_3{^-}$) status indicators of ground water in 2013 were significantly lower than the ones in 2000. Overall, the water quality indicators of surface water in 2013 were higher than the ones in 2012, except for pH and DO. The groundwater quality indicators in 2013 were lower than those of previous years. The optimal management indicators were calculated to assess agricultural surface water and groundwater quality. The findings of this study indicated that the state indicators could play a significant role to establish policies and procedures for managing and conserving water resources. This study also discussed water pollution caused by agricultural and industrial effluents.
Kim, Jong-Hwa,Kim, Young-Kyun,Yi, Yang-Jin,Yun, Pil-Young,Lee, Hyo-Jung,Kim, Myung-Jin,Yeo, In-Sung,Yun, Pil-Young,Lee, Hyo-Jung,Kim, Myung-Jin,Yeo, In-Sung 대한치과보철학회 2009 The Journal of Advanced Prosthodontics Vol.1 No.3
STATEMENT OF PROBLEM. Many dental clinicians are concerned about immediate loading of inserted implants. However, there have been few clinical studies surveying the success rates of immediate loading, based on Korean implant systems. PURPOSE. The aim of this study was to evaluate the outcome of immediate functional loading of the implant (SinusQuick EB, Neobiotech Co., Seoul, Korea) in partially edentulous maxilla or mandible. MATERIAL AND METHODS. Total 15 implants were placed. Within 2 weeks after implant insertion, provisional implant-supported fixed partial dentures were delivered to the patients. Quantitatively, marginal bone loss was measured at the time of immediate loading, after 3-months of continued loading and at the last follow-up. The mean follow-up period was 4.8 months. RESULTS. Mean marginal bone loss from implant surgery to early loading, 3-months follow-up and last follow-up was 0.03 %0.07 mm, 0.16 %0.17 mm and 0.29%0.19 mm. No implant failed up to 6 months after insertion, resulting in a 100% survival rate. CONCLUSION. Immediate loading exhibited high success rate in partial edentulism for up to 6 months. Well-controlled long term clinical studies with large sample size are necessary to confirm this finding.
Kim, Jong-Hyun,Choi, Eun Hwa,Park, Su Eun,Kim, Yae-Jean,Jo, Dae Sun,Kim, Yun-Kyung,Eun, ByungWook,Lee, Jina,Lee, Soo-Young,Lee, Hyunju,Kim, Ki Hwan,Kim, Kyung-Hyo The Korean Pediatric Society 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.12
This report includes the recommended immunization schedule table for children and adolescents based on the 8th (2015) and revised 7th (2012) Immunization Guidelines released by the Committee on Infectious Diseases of the Korean Pediatric Society (KPS). Notable revised recommendations include: reorganization of the immunization table with a list of vaccines on the vertical axis and the corresponding age on the horizontal axis; reflecting the inclusion of Haemophilus influenzae type b vaccine, pneumococcal conjugate vaccine, and hepatitis A vaccine into the National Immunization Program since 2012; addition of general recommendations for 2 new Japanese encephalitis (JE) vaccines and their interchangeability with existing JE vaccines; addition of general recommendations for quadrivalent meningococcal conjugate vaccines and scope of the recommended targets for vaccination; and emphasizing catch-up immunization of Tdap vaccine. Detailed recommendations for each vaccine may be obtained from the full KPS 8th Immunization Guidelines.
Kim, Ki-Byoung,Yun, Tae-Soon,Lee, Jong-Chul,Kim, Il-Doo,Lim, Mi-Hwa,Kim, Ho-Gi,Kim, Jong-Heon,Lee, Byungje,Kim, Na-Young The Korean Institute of Electromagnetic Engineerin 2002 한국전자파학회논문지 Vol.13 No.8
In this paper, the performance of Au / $Ba_{0.5}Sr_{0.5}TiO_3$ (BST) / Magnesium oxide (MgO) two-layered electrically tunable band-pass Filters (BPFs) is demonstrated. The devices consist of microstrip, coplanar waveguide (CPW), and conductor-backed coplanar waveguide (CBCPW) structures. These BST thin film band-pass filters have been designed by the 2.5 D field simulator, IE3D, Zeland Inc., and fabricated by thin film process. The simulation results, using the 2-pole microstrip, CPW, and CBCPW band-pass filters, show the center frequencies of 5.89 GHz, 5.88 GHz, and 5.69 GHz, and the corresponding insertion losses are 2.67 dB, 1.14 dB, and 1.60 dB, with 3 %, 9 %, and 7 % bandwidth, respectively. The measurement results show the center frequencies of 6.4 GHz, 6.14 GHz, and 6.04 GHz, and their corresponding insertion losses are 6 dB, 4.41 dB, and 5.41 dB, respectively, without any bias voltage. With the bias voltage of 40 V, the center frequencies for the band-pass filters are measured to be 6.61 GHz, 6.31 GHz, and 6.21 GHz, and their insertion losses are observed to be 7.33 dB, 5.83 dB, and 6.83 dB, respectively. From the experiment, the tuning range for the band-pass filters are determined as about 3 % ~ 8 %. 본 논문은 $Ba_{0.5}$Sr$_{0.5}$TiO$_3$(BST) 박막을 이용한 대역 통과 여파기를 설계, 제작한 것으로 마이크로스트립 과 코플래너 웨이브가이드(CPW), CBCPW 전송 선로 구조에서 각 구조의 여파기 특성을 비교하였다. 제작된 여파기는 전압 0V 인가시 각각 6.4 GHz, 6.14 GHz, 6.04 GHz의 중심 주파수와 6 dB, 4.41 dB, 5.41 dB의 삽입 손실이 측정되었으며, 40V 인가시 중심 주파수 6.61 GHz, 6.31 GHz, 6.21 GHz와 삽입 손실 7.33 dB, 5.83 dB, 6.83 dB로 나타났다. 본 논문에서 제작된 각각의 대역 통과 야파기는 가변 범위가 약 3 % - 8 %이며, 무선랜 대역에 응용할 수 있도록 설계 및 제작되었다.다.