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홍삼 추출물이 감마선에 조사된 생쥐 혈청에서의 효소 활성에 미치는 영향
김동윤,김동조,박영순,전철,장재철,황갑수 群山大學校基礎科學硏究所 1992 基礎科學硏究 Vol.7 No.-
홍삼 추출물이 감마선 조사로 인하여 방사선 장해를 받은 생쥐의 효소 활성도 변화에 미치는 회복효과를 관찰하기 위하여 생리적 식염수만을 투여한 생쥐를 대조군으로 하여 홍삼 추출물 투여군, 방사선처리후 생리적 식염수 투여군과 방사선처리 후 홍삼 추출물 투여군으로 분류하여 5Gy의 감마선을 전신조사한 후 즉시 마리당 5.5mg의 홍삼 추출물을 투여하고 1일, 4일, 9일, 17일 및 30일에 혈청에서의 LDH, GOT, GOP, ALP및 ACP의 활성도 변화를 측정 비교하였다. 그 결과 홍삼 추출물만을 투여한 군에서는 GOT, ALP 및 ACP활성은 대조군과 거의 비슷한 경향을 보였으나, LDH의 활성도 변화는 매우 불안정하였으며, 방사선조사 후 생리적 식염수 투여군은 모든 효소에서의 활성이 대조군에 비하여 심한 변동을 보였으나 방사선조사 후 홍삼 추출물 투여군에서는 LDH를 제외한 모든 효소의 활성이 방사선 조사후 생리적 식염수 투여군보다 빠르게 회복됨을 관찰하였다. 이와 같이 방사선 조사 후 홍삼 추출물의 투여는 방사선 피폭으로 야기되는 GOT, GPT, ALP및 ACP의 활성도 변화에 대하여 회복효과가 있음을 나타내었다. The study was undertaken to investigate effects of a single dose of red ginseng extracts on enzymes activities in the serum. The experiments were carried out on wholebody irradiated (5Gy ??) and non-irradiated male ICR mice. In non-irradiated mice, glutamate oxaloacetate transaminase(GOT), alkaline phosphatase (ALP) and acid phosphatase(ACP) activity were not changed by administration of red ginseng extract, but the activity of lactate dehydrogenase(LDH) activity was changed significantly. In irradiated mice, GOT, glutamate pyruvate transaminase(GPT), LDH, ALP and ACP activities were changed significantly by administration of the saline. But the recovery of GOT, GPT, ALP and ACP activities stimulated by the red ginseng extract was observed earlier than by the treatment of saline. Experimental results suggested that red ginseng extracts have the recovery effect on the changed enzyme activity after radiation injury.
Rijuta G. Saratale,Ganesh D. Saratale,Jo Shu Chang,Sanjay P. Govindwar 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.4
Immobilized cells of Proteus vulgaris NCIM 2027 completely decolorized C.I. Reactive Blue 172 (50mg/L) within 8 h along with a nearly 80% reduction in TOC and COD. The dye degradation efficiency of the immobilized cells was further improved by optimizing the physicochemical conditions, including agitation, temperature,pH, dye concentration, and biomass loading. Microbial toxicity study revealed the non-toxic nature of the degraded products. Repeated-batch decolorization was conducted to evaluate the reusability of the immobilized cells. The immobilized cells were used for continuous dye decolorization in a fixed bed bioreactor under different volumetric flow rates and dye feeding concentrations. In addition, the immobilized cells were applied to decolorize a mixture of seven reactive dyes in batch and continuous modes, resulting in efficient decolorization (in terms of ADMI value) and significant reduction in TOC and COD. This suggests the potential of using immobilized cells to treat dye-containing wastewater.