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RISS 인기검색어
- 검색키워드
- 저자 : Jiangeng Li (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Effect of Pluronic P123 and F127 Block Copolymer on P-glycoprotein Transport and CYP3A Metabolism
Yanbin Guan,Gao Li,Jiangeng Huang,Lan Zuo,Jiaqiang Xu,Luqin Si,Jun Qiu 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.10
The aim of the present study was to evaluate the effect of pluronic P123 (P123) and pluronic F127 (F127) on intestinal P-glycoprotein (P-gp) and cytochrome P450 3A using the specific substrates rhodamine-123 (R-123) and midazolam, respectively. Caco-2 cells and everted gut sacs were used as models of intestinal mucosa to assess intestinal absorption of R-123, while rat intestinal microsomes were utilized to examine the effect of P123 and F127 on in vitro midazolam metabolism. P123 and F127 were observed to increase the intracellular accumulation of R-123 in Caco-2 cells in a dose-dependent manner. P123 significantly lowered the efflux ratio of R-123 at two concentrations in Caco-2 monolayers, whereas F127 lowered the efflux ratio only at 1%. Moreover, both pluronics markedly enhanced mucosal to serosal absorption of R-123 in excised ileum of rats. However, no significant difference in relative enzyme activity were observed between P123- or F127-treated and control groups, regardless of the concentrations of P123 and F127 studied. Collectively, these results obtained from the present study demonstrated that P123 and F127 were capable of inhibiting the intestinal P-gp activity, but had little or no effect on intestinal cytochrome P450 3A activity, indicating that P123 and F127 can potentially be used as pharmaceutical ingredients to improve the oral bioavailability of coadministered P-gp substrates via P-gp efflux pump inhibition.
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Controlling Ejection State of a Pneumatic Micro-droplet Generator Through Machine Vision Methods
Fei Wang,Yiwei Wang,Weijie Bao,Hui Zhang,Jiangeng Li,Zhihai Wang 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.4
Pneumatic micro-droplet ejection is a printing technique that has potential applications in many fi elds, especially in thefi eld of bio-printing. The ejection is via a solenoid valve being briefl y turned on, so that high pressure gas enters the liquidreservoir, forming a gas pressure pulse, forcing the liquid out through a tiny nozzle to form a micro-droplet. For bio-printingapplications, the bio-inks are typically non-standard. The diffi culties are not only that the initial working parameters arediffi cult to set, but also the working conditions change over time in many cases. In order to maintain a stable single-dropejection state, a machine vision based ejection monitoring was designed to obtain the number, positions and sizes of thedroplets for each ejection, and a feedback control is realized by adjusting the “ON” time of the solenoid valve or the gaspressure at the front end of the solenoid valve.
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