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김지혜(Kim Ji-hye),마유진(Ma Yu-jin),박지민(Bak Ji-min),정다빈(Jeong Da-bin),정은희(Jeong Eun-he),문차홍(Moon Cha-hong),안지은(An Ji-eun),이상운(Lee Sang-un) 한국방송·미디어공학회 2020 한국방송공학회 학술발표대회 논문집 Vol.2020 No.11
COVID-19로 인해 많은 사람들이 다양한 오프라인 활동을 즐기지 못하고 있다. 따라서 포터블 중계 시스템을 이용하여 온택트 시대에 맞는 소통 콘텐츠 제작이 요구되고 있다. 본 논문에서는 방송 송출 프로그램을 이해하고 그를 이용한 CG사용과 크기가 작은 포터블 중계 시스템의 장점을 살려 장소에 제약이 없는 실시간 유튜브 스트리밍 구현을 설계하였다.
Ji, Yu-Bin,Chen, Ning,Zhu, Hong-Wei,Ling, Na,Li, Wen-Lan,Song, Dong-Xue,Gao, Shi-Yong,Zhang, Wang-Cheng,Ma, Nan-Nan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21
Alkaloids are the most extensively featured compounds of natural anti-tumor herbs, which have attracted much attention in pharmaceutical research. In our previous studies, a mixture of major three alkaloid components (5, 6-dihydrobicolorine, 7-deoxy-trans-dihydronarciclasine, littoraline) from Hymenocallis littoralis were extracted, analyzed and designated as AHL. In this paper, AHL extracts were added to human liver hepatocellular cells HepG-2, human gastric cancer cell SGC-7901, human breast adenocarcinoma cell MCF-7 and human umbilical vein endothelial cell EVC-304, to screen one or more AHL-sensitive tumor cell. Among these cells, HepG-2 was the most sensitive to AHL treatment, a very low dose ($0.8{\mu}g/ml$) significantly inhibiting proliferation. The non-tumor cell EVC-304, however, was not apparently affected. Effect of AHL on HepG-2 cells was then explored. We found that the AHL could cause HepG-2 cycle arrest at G2/M checkpoint, induce apoptosis, and interrupt polymerization of microtubules. In addition, expression of two cell cycle-regulated proteins, CyclinB1 and CDK1, was up-regulated upon AHL treatment. Up-regulation of the Fas, Fas ligand, Caspase-8 and Caspase-3 was observed as well, which might imply roles for the Fas/FsaL signaling pathway in the AHL-induced apoptosis of HepG-2 cells.
홍지원,이승우,박덕영,마득상 대한구강보건학회 2000 大韓口腔保健學會誌 Vol.24 No.4
The purpose of this study was to evaluate school-based oral health program of suburban area of Kangnung city arid to obtain basic data for improving the efficiency of the program. In 4 elementary schools of suburban area, school-based oral health programs including fluoride mouth rinsing, pit and fissure sealing for first molars and oral health education were started from 1996. Baseline dental examination was done for 535 students in 1996. 212 students who were 6 to 8 years-old in 1996 were examined every May for 3 years. Among these, 157 students were successfully followed for 3 years. The obtained results were as follows: 1. DMFT index was significantly lower in children involved in school-based oral health programs from their first grade school life than those involved from other grades(p<0.05). 2. Dental caries incidence of permanent teeth was the most prevalent in the first molars. 3. The major cause of dental caries incidence was due to failure of follow-up to seal pits and fissures. 4. Resources of school-based oral health programs should be focused to the fast grade students. 5. Detailed directory including the method of planning for programs, criteria for selecting subjects and teeth to be seated should be developed. Also, the method of writing on charts is need to be standardized.
Detection of <i>MYCN</i> Amplification in Serum DNA Using Conventional Polymerase Chain Reaction
Ma, Youngeun,Lee, Ji Won,Park, Soo Jin,Yi, Eun Sang,Choi, Young Bae,Yoo, Keon Hee,Sung, Ki Woong,Koo, Hong Hoe The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.9
<P>Neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood and is characterized by a wide range of clinical behaviors. Amplification of <I>MYCN</I> is a well-known poor prognostic factor in NB patients. As the <I>MYCN</I> amplification status is usually tested using tumor specimens, lengthy and invasive procedures are unavoidable. To evaluate the possibility of detecting <I>MYCN</I> amplification without invasive procedure, we performed conventional polymerase chain reaction (PCR) analysis to identify <I>MYCN</I> amplification using the preserved serum DNA. PCR of serum DNA was done in 105 NB patients whose <I>MYCN</I> status had been confirmed by fluorescence in situ hybridization. <I>MYCN</I> amplification was evaluated as the ratio of signal intensities between <I>MYCN</I> and <I>NAGK</I> (M/N ratio). When regarding the tissue FISH results as a reference, 10 patients had <I>MYCN</I>-amplified (MNA) NB, and 95 had non-MNA NB. The M/N ratio of the MNA group (median 2.56, range 1.01-3.58) was significantly higher than that of the non-MNA group (median 0.97, range 0.67-5.18) (<I>P</I> < 0.001). In the receiver operating characteristic curve analysis, the area under the curve was 0.957 (95% confidence interval 0.898–1.000; <I>P</I> < 0.001), and it showed 90.9% sensitivity and 97.9% specificity with the selected cut-off value set as 1.6. The detection of <I>MYCN</I> amplification using conventional PCR analysis of serum samples seems to be a simple and promising method to evaluate the <I>MYCN</I> status of NB patients. Further study with a larger set of patients is needed to confirm the accuracy of this result.</P>
XPC 939A>C and 499C>T Polymorphisms and Skin Cancer Risk: a Meta-analysis
Ji, Geng,Lin, Yuan,Cao, Song-Yu,Li, Luo-Zhu,Chen, Xin-Long,Sun, Bu-Mei,Chen, Chuan-Jun,Ma, Hong-Xia Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10
The xeroderma pigmentosum complementation group C gene (XPC) has been identified as important for repairing UV-related DNA damage. Some subtle changes in this gene may impair repair efficiency and influence susceptibility to human cancers, including skin cancer. Two polymorphisms in XPC, 939A>C (rs2228001) and 499C>T (rs2228000), are considered to have possible associations with the risk of skin cancer, but the reported results have been inconsistent. Here we performed a meta-analysis of the available evidence regarding the relationship between these two polymorphisms and the risk of skin cancer. All relevant studies were searched using PubMed, Embase and Web of Science before February 2012. A total of 8 case-control studies were included in this analysis, and no convincing associations between the two polymorphisms and risk of skin cancer were observed in any of the genetic models. Stratified analyses by skin cancer type also did not detect significant associations in any subgroup. This meta-analysis suggested that the XPC 939A>C and 499C>T polymorphisms may have little involvement in susceptibility to skin cancer.
Ma, Kyoung Tak,Yang, Jong Yun,Kim, Ji Hyun,Kim, Na Rae,Hong, Samin,Lee, Eun Suk,Seong, Gong Je,Kim, Chan Yun Lippincott Williams Wilkins, Inc. 2012 Journal of glaucoma Vol.21 No.5
PURPOSE: To investigate the surgical results of Ahmed valve implantation with intraoperative bevacizumab injection in patients with neovascular glaucoma (NVG). METHODS: A retrospective comparative case series review was conducted on 52 eyes with NVG who underwent Ahmed glaucoma valve implantation with or without intraoperative bevacizumab intravitreal injection. In the intraoperative intravitreous bevacizumab injection group (IVB group, 20 eyes), 1.25 mg of bevacizumab was injected into the vitreous cavity during Ahmed valve implantation. In the control group (32 eyes), only Ahmed valve implantation was performed. Surgical failure was defined when (1) the postoperative intraocular pressure was over 21 mm Hg at consecutive clinic visits, (2) the visual acuity became light perception negative, (3) additional antiglaucomatic surgery was required, or (4) devastating operative or postoperative complications were noted. RESULTS: Although the success rate in the IVB group (70.0%) was higher than that in the control group (62.5%) 1 year after operation, the differences were not statistically significant (P=0.828 by log-rank test). Mean intraocular pressures in the IVB group were significantly lower than those of the control group at 12 and 15 months (P<0.05 by the Mann-Whitney U test). Postoperative complications were similar between the 2 groups. Preoperative history of trabeculectomy was a significant risk factor for surgical failure of Ahmed valve implantation in NVG (relative risk=4.618; P=0.018 by Cox regression model). CONCLUSIONS: Intraoperative IVB injection does not seem to be helpful for better surgical outcomes of Ahmed valve implantation in NVG. A history of trabeculectomy is a risk factor for failure after Ahmed valve implantation in patients with NVG.
Hong, Sa-Ik,Kwon, Seung-Hwan,Hwang, Ji-Young,Ma, Shi-Xun,Seo, Jee-Yeon,Ko, Yong-Hyun,Kim, Hyoung-Chun,Lee, Seok-Yong,Jang, Choon-Gon The Korean Society of Applied Pharmacology 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.2
Sleep, which is an essential part of human life, is modulated by neurotransmitter systems, including gamma-aminobutyric acid (GABA) and dopamine signaling. However, the mechanisms that initiate and maintain sleep remain obscure. In this study, we investigated the relationship between melatonin (MT) and dopamine D2-like receptor signaling in pentobarbital-induced sleep and the intracellular mechanisms of sleep maintenance in the cerebral cortex. In mice, pentobarbital-induced sleep was augmented by intraperitoneal administration of 30 mg/kg MT. To investigate the relationship between MT and D2-like receptors, we administered quinpirole, a D2-like receptor agonist, to MT- and pentobarbital-treated mice. Quinpirole (1 mg/kg, i.p.) increased the duration of MT-augmented sleep in mice. In addition, locomotor activity analysis showed that neither MT nor quinpirole produced sedative effects when administered alone. In order to understand the mechanisms underlying quinpirole-augmented sleep, we measured protein levels of mitogen-activated protein kinases (MAPKs) and cortical protein kinases related to MT signaling. Treatment with quinpirole or MT activated extracellular-signal-regulated kinase 1 and 2 (ERK1/2), p38 MAPK, and protein kinase C (PKC) in the cerebral cortex, while protein kinase A (PKA) activation was not altered significantly. Taken together, our results show that quinpirole increases the duration of MT-augmented sleep through ERK1/2, p38 MAPK, and PKC signaling. These findings suggest that modulation of D2-like receptors might enhance the effect of MT on sleep.