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RISS 인기검색어
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- 저자 : Jewan Kaiser Hwang (검색결과 2 건)
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JinYoung Park,HeeChul Lee,Jewan Kaiser Hwang 대한의학레이저학회 2022 MEDICAL LASERS Vol.11 No.1
Background and ObjectivesAlthough skin rejuvenation is not within the usual repertoire of the Q-switched 1064 nm Nd:YAG (Q-NDY) laser, the development of a multi-depth focusing (MDF) handpiece allowing user-selectable depths of focus has changed this. The current in-house pilot study was designed to assess the safety and efficacy of a Q-NDY laser fitted with an MDF handpiece in the treatment of enlarged pores and acne scars.Materials and MethodsTen patients with enlarged pores and acne scars were recruited into the study as volunteers. Clinical photographs were taken at baseline and then at six weeks (A1) and three months (A2) after the final treatment, based on which a quintile scale physician global assessment (PGA) was obtained at A2 scored by two independent blinded dermatologists. Patients subjectively scored their satisfaction with the treatment in a questionnaire at A2, also on a quintile scale.ResultsIn general, patients showed a statistically significant improvement in both the pores and acne scars at both A1 and A2, with a trend towards continued improvement between the first and second assessments, more particularly for the acne scars. The average percentage improvements for the pores at A1 and A2 were 48.45 ± 16.1% and 57.8 ± 15.2% (p = 0.001 for both), respectively, for acne scars, the respective values were 27.8 ± 15.0% and 34.2 ± 24.3% (p = 0.0008 for A1, 0.0004 for A2). No difference was seen between the subjects who had three sessions and those who had four, suggesting that the 3-treatment protocol was ideal, although numbers were too small to make any generalization. The average PGA score was 3.3/4 and the average subject satisfaction score was 3.4/4. The average pain score was 3.7 (range 3-5), and no adverse events were reported during both the treatment and follow-up periods.ConclusionFurther controlled studies in larger populations are warranted to confirm the optimistic results of this pilot study.
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Jiyoon Jung,Hyemin Kim,Jinyoung Park,Jewan Kaiser Hwang 대한의학레이저학회 2022 MEDICAL LASERS Vol.11 No.4
Background and Objectives: A novel multipulse mode has been developed for the Q-switched 1,064 nm Nd:YAG laser (Q-NYL) which may help prevent rebound pigmentation after laser toning for melasma. The present study compared the depigmentation efficacy and latency of single pulse and multipulse modes over a range of fluences using the zebrafish model.Materials and Methods: Ninety zebrafish were equally allocated to 9 groups to compare a Q-NYL single pulse mode (QS) using a 7 mm collimated handpiece with double- (PTP), triple- (Q3) and quadruple- (Q4) pulse modes over a range of fluences. Timing and degree of repigmentation were analyzed at the 14- and 49-day post-treatment assessments in each group using light microscopy-captured microphotography with image analysis and a Student’s t-test.Results: There was an attrition rate of around 1 zebrafish per group per assessment, leaving a minimum of 3 animals per group for the final assessment. All zebrafish showed significant pigment removal at the 2-week assessment (p < 0.01 to < 0.0001). However, the best result among all groups with a significantly longer pigment-free latency period at the 7-week assessment was obtained in the Q4 4 × 0.3 J/cm2/micropulse group, delivering the equivalent in the skin of 1.2 J/cm2 (p < 0.0001 at 2 weeks, p < 0.01 at 7 weeks).Conclusion: The quadruple pulse mode of Q-NYL laser toning demonstrated effective, safe and long-term repigmentation-free efficacy in the zebrafish model, suggesting potential translation to controlled and double-blind studies on melasma in human patients.
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