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- 저자 : Jeon Hyesoo (검색결과 4 건)
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Hyesoo Jeon,Shin-Hyeok Park,Sohae Cho,Sol Jeong,Nam Geun Cho 대한침구의학회 2023 대한침구의학회지 Vol.40 No.2
Herein, we report the effectiveness of Korean medicine for the treatment of postherpetic upper limb weakness and pain. The patient received a combination of Korean medicine treatment modalities, including electroacupuncture, pharmacopuncture, and herbal medicine. Muscle strength and pain were evaluated using a manual muscle test (MMT) and a Numerical Rating Scale (NRS), respectively. The overall MMT score improved after hospitalization, and elbow extension improved from 3+ at admission to 5 at discharge. The NRS score improved to 2 at discharge. This study suggests the effectiveness of a combination of Korean medicine modalities in treating postherpetic motor nerve paralysis.
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Eunbyul Cho,Shin-Hyeok Park,Hyesoo Jeon,Nam Geun Cho 대한침구의학회 2023 대한침구의학회지 Vol.40 No.1
Very few studies have been reported on upper extremity replantation following traumatic amputation. This case study aimed to report the progress of a patient treated with complex Korean medicine for 1 year after elbow replantation. The patient mainly complained of forearm sensory loss, muscle weakness, and hand pain after undergoing upper limb amputation and emergency replantation. He was hospitalized for approximately 50 days and then received outpatient treatment for approximately 10 months, followed by electroacupuncture, moxibustion, Chuna, herbal medicine, and transcutaneous electrical nerve stimulation. The muscle strength of the wrist joint improved to good (flexion) and fair (extension), and the forearm sensation was partially recovered approximately 10 months after the onset. To our knowledge, this is the first case report on replantation rehabilitation in Korean medicine, and it suggests that complex Korean medicine treatment might be beneficial for patients undergoing replantation after upper extremity amputation.
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조은별,Han Young-Min,강연석,김재효,Shin Min-Seop,Oh Myungjin,정현종,Jeon Hyesoo,조남근,임정태 대한침구의학회 2022 대한침구의학회지 Vol.39 No.2
Background: The objective structured clinical examination (OSCE) is used in the colleges of Korean Medicine, but few studies have validated the OSCE evaluation criteria or post-education questionnaires. Diagnostic ultrasound is used in Korean medicine treatment including acupuncture, acupotomy, and pharmacopuncture to increase the safety and efficacy of treatment. We aimed to develop and validate a OSCE checklist and questionnaire for diagnostic musculoskeletal ultrasound training.Methods: A OSCE checklist and rubric for diagnostic ultrasound training, and questionnaire was developed using literature research. Eight expert panelists verified each draft item in a single-round survey. Items with a content validity ratio (CVR) < 0.75 were excluded or modified to reflect the experts’ opinions.Results: The OSCE checklist and rubric for diagnostic ultrasound training focusing on volar wrist and carpal tunnel syndrome included: 15 items revised according to CVR and expert opinions, the pre-examination procedure, structures to be identified by ultrasound, scans with 2 diagnostic criteria for carpal tunnel syndrome, an explanation of the exam results, and the post exam procedure. The questionnaire consisted of 15 items, including the overall evaluation of training, the effect of the OSCE, and the perception of the ultrasound. All 6 self-evaluation items were not revised, as they had a CVR of ≥ 0.75.Conclusion: An ultrasound OSCE for scanning the volar wrist and diagnosing carpal tunnel syndrome was developed using 15 validated tasks, 15 survey questions about ultrasound training, and 6 questions for selfevaluation. These results may be used in the future for education in diagnostic ultrasound.
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멜라닌 생성 및 항산화 활성에 미치는 그라비올라 잎 추출물의 영향
이규원(Kyuwon Lee),장지원(Jiwon Jang),박수민(Sumin Park),강기훈(Kihun Kang),윤혜수(Hyesoo Yoon),하예진(Yejin Ha),전소정(Sojeong Jeon),고혜주(Hye Ju Ko),김문무(Moon-Moo Kim),오영희(Yunghee Oh) 한국생명과학회 2019 생명과학회지 Vol.29 No.6
본 연구의 목적은 그라비올라 잎의 항산화 효능과 멜라닌 생성 촉진효과를 조사하는 것이다. 먼저 AMME와 유기용매 별 분획물의 항산화 효능을 확인하기 위해 DPPH radical 소거능과, reducing power를 수행하였다. AMME와 유기용매별 분획물은 농도에 비례하여 항산화 효능이 증가하였으며, 그 중 ethyl acetate 분획물에서 가장 높은 항산화 효능을 보였다. 항산화 효능을 보인 분획물들의 멜라닌 생성에 미치는 영향을 확인하기 위해 tyrosinase activity를 수행한 결과 AMME, ethyl acetate, hexane 분획물에서 농도에 비례하여 멜라닌 생성 촉진효능이 나타났다. 그 중에서 AMME 유기 용매 별 분획물에서 멜라닌 합성 효능이 가장 좋은 hexane 분획물을 칼럼크로마토그래피를 통해 12가지 분획물로 나누어 항산화 실험과 멜라닌 합성실험을 수행하였다. 그 중 Fig. 8에서 DPPH radical 소거능과 환원력이 가장 우수한 것으로 나타났다. In vitro melanin 합성 실험 결과, Fr. 7은 64 μg/ml 농도에서 260%의 멜라닌 합성 효능을 보였고, Fr. 8은 64 μg/ml 농도에서 184%의 멜라닌 합성 효능이 관찰되었다. 최종적으로 B16F1 세포에서 Fr. 8의 4 μg/ml 농도에서 34%의 멜라닌 합성 효능을 보였다. LC-MS 결과 Fr. 7이 617의 분자량을 나타냈고, Fr. 8이 분자량 619의 분자량을 나타냈다. FT-IR 결과 Fig. 7과 Fig. 8 모두 Bis(2-hydroxyethly)dimerate와 비슷한 유효성분을 나타냈다. 이상의 결과로 그라비올라 잎은 천연 항산화제 또는 멜라닌 생성 촉진효과와 관련 있는 모발 제품 개발에 응용가능성이 있다고 판단된다. The purpose of this study was to investigate the effect of methanolic extracts of graviola, Annona muricate leaves (AMME) on antioxidant activity and melanin production. First of all, DPPH radical and reducing power were performed to determine the antioxidant effect of AMME and organic solvent fractions. AMME and organic solvent fractions showed antioxidative activity in a concentration dependent manner. The ethyl acetate fraction of AMME among organic solvent fractions showed the highest antioxidant activity. Moreover, tyrosinase activity was performed to confirm the effect of organic fractions on melanin production. AMME, ethyl acetate, and hexane fractions increased tyrosinase activity a dose dependent manner. Next, the hexane fraction with the best effect on melanin synthesis in AMME organic solvent fraction was divided into 12 fractions by silica column chromatography. Among them, the fraction 7 and 8 showed the highest DPPH radical scavenging activity and reducing power. In addition, the fraction 7 and 8 at 64 μg/ml showed melanin synthesis by 260% and 184%, respectively. Finally, the fraction 8 at 4 μg/ml showed melanin synthesis by 34% in B16F1 cells. LC-MS analysis showed that fraction 7 and fraction 8 have a molecular weight of 617 and 619, respectively. FT-IR analysis showed that fractions 7 and 8 is similar to bis(2-hydroxyethly)dimerate. Above results suggest that graviola leaves extracts could be applicable to the development of natural antioxidants or hair cosmetics which are related to the promoting effect of melanin production.
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