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RISS 인기검색어
- 검색키워드
- 저자 : Jarman, Richard G. (검색결과 2 건)
- 무료
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Potential of the Microbiome as a Biomarker for Early Diagnosis and Prognosis of Breast Cancer
Robyn Jarman,Sarah Ribeiro-Milograna,Wouter Kalle 한국유방암학회 2020 Journal of breast cancer Vol.23 No.6
Breast cancer affects 1 in 8 women globally, and is the leading cause of cancer-related deaths in female patients. The majority of breast cancer cases are of unknown cause; few are linked to genetic predisposition, and some arise sporadically. Finding the cause of these sporadic cases is an important area in cancer research. Investigations into the microbiome show links between microbiome dysbiosis and breast cancer, with possible mechanisms in the association of the microbiome and breast cancer, including estrogen metabolism and the ‘oestrobolome,’ immune regulation, propensity for obesity, and the regulation of the tumor microenvironment. This paper reviews the literature and discusses the potential implications of links between the microbiome and breast cancer, and concludes that the microbiome may have significant applications as a biomarker for breast cancer diagnosis, prognosis, and management. Further investigation is crucial, since modification of the microbiome can, at the most basic level, be achieved via dietary modification.
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Clapham, Hannah E.,Rodriguez-Barraquer, Isabel,Azman, Andrew S.,Althouse, Benjamin M.,Salje, Henrik,Gibbons, Robert V.,Rothman, Alan L.,Jarman, Richard G.,Nisalak, Ananda,Thaisomboonsuk, Butsaya,Kalay Oxford University Press 2016 The Journal of Infectious Diseases Vol.213 No.9
<P>The immune response to dengue virus (DENV) infection is complex and not fully understood. Using longitudinal data from 181 children with dengue in Thailand who were followed for up to 3 years, we describe neutralizing antibody kinetics following symptomatic DENV infection. We observed that antibody titers varied by serotype, homotypic vs heterotypic responses, and primary versus postprimary infections. The rates of change in antibody titers over time varied between primary and postprimary responses. For primary infections, titers increased from convalescence to 6 months. By comparing homotypic and heterotypic antibody titers, we saw an increase in type specificity from convalescence to 6 months for primary DENV3 infections but not primary DENV1 infections. In postprimary cases, there was a decrease in titers from convalescence up until 6 months after infection. Beginning 1 year after both primary and postprimary infections, there was evidence of increasing antibody titers, with greater increases in children with lower titers, suggesting that antibody titers were boosted due to infection and that higher levels of neutralizing antibody may be more likely to confer a sterilizing immune response. These findings may help to model virus transmission dynamics and provide baseline data to support the development of vaccines and therapeutics.</P>
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