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방사선 치료 시 EPID와 OBI의 유용성에 관한 연구
허진행(Jinhang Heo),신재봉(Jaebong Shin),구효근(Hyogeun Koo),송재흥(Jaeheung Song),구재흥(Jaeheung Koo) 한국방사선학회 2014 한국방사선학회 학술대회 논문집 Vol.2014 No.춘계
선형가속기를 이용한 방사선 치료가 증가되면서 치료의 정확성 및 재현성 향상을 위한 치료부위 확인 장치도 많은 발전 을 거듭해 왔다. 본 연구는 방사선 치료 전 치료부위 확인 영상장치인 EPID와 OBI를 이용하여 치료부위의 영상을 획득하 였다. 모의치료 시 팬톰 자세 및 위치 영상과 치료부위 확인 영상을 비교하여 두 장치의 유용성을 평가하고자 한다. 팬톰이 위치한 치료테이블을 측면으로 2 cm, 5 cm, 10 cm씩 각각 이동하여 두 장치의 오차를 확인하였다. 테이블을 측면으 로 10 cm 이동한 결과 0.4∼0.6 cm의 오차가 나타났지만, 테이블의 2 cm, 5 cm의 거리 이동에서는 두 영상에서 오차가 작게 나타났다. 즉, 두 장치모두 치료부위의 이동은 오차가 발생하지만 OBI를 이용한 영상이 EPID에 비해 환자의 치료 부위를 확인하기에 높은 화질의 영상을 제공하므로 보다 객관적이고 정확한 치료부위의 보정이 가능하며, 임상에 근무하 는 방사선사의 업무 효율 또한 증가 될 것으로 사료된다. With increased radiotherapy using a linear accelerator, there has been continuous progress in devices locating treatment sites to improve the accuracy and repeatability of treatment. The study acquired the images of treatment sites using EPID and OBI which are image equipment to identify treatment sites prior to radiation therapy. It attempts to evaluate the usefulness of the two devices by comparing the image of the postures and locations of a phantom with those of locating treatment sites. The error in the images from the devices was identified by moving the treatment table where the phantom was located 2 cm, 5 cm, 10 cm laterally. The error range in the images was 0.4∼0.6 cm when the table was moved 10cm, while it was smaller when the table was moved 2 cm and 5 cm. In other words, while moving treatment sitescaused errors in both devices, since OBI provides higher quality images than EPID, enable more objectiveand accurate locating of treatment sites, it is considered to increase work efficiency of radiological technologists in clinics.
Mah, Shinmee,Jang, Jaebong,Song, Daesun,Shin, Yongje,Latif, Muhammad,Jung, Yongwon,Hong, Sungwoo The Royal Society of Chemistry 2019 Organic & Biomolecular Chemistry Vol.17 No.1
<P>Altered expression or hyperactivation of anaplastic lymphoma kinase (ALK), as a consequence of translocations or point mutations, is one of the main oncogenic drivers in non-small cell lung cancer. Using structure-based design and <I>in vitro</I> enzyme assays, we identified 3-heteroarylcoumarin as a new template for the development of novel fluorescent ALK inhibitors. Molecular simulation provided structural insights for the design of 3-heteroarylcoumarin derivatives, which were easily prepared through efficient synthetic approaches including direct C-H cross coupling. Importantly, these coumarin-based ALK inhibitors can be tracked using microscopy techniques: we illustrated the use of the most potent compound in this series, 5a, (ALK/IC50 = 0.51 μM, <I>λ</I>emi = 500 nm, <I>ϕ</I>F = 0.29) to monitor its subcellular distribution pattern by confocal fluorescence microscopy.</P>
Jiwook Kim,Tak Kyu Oh,Jaebong Lee,Saeyeon Kim,In-Ae Song 대한중환자의학회 2019 Acute and Critical Care Vol.34 No.1
Background:Postoperative body temperature is closely associated with prognosis although there is limited research regarding this association at postoperative intensive care unit (ICU) admission. Furthermore, no studies have used digital axillary thermometers to measure postoperative body temperature. This study investigated the association between mortality and postoperative temperature measured using a digital axillary thermometer within 10 minutes after ICU admission. Methods:This retrospective observational study evaluated data from adult patients admitted to an ICU after elective or emergency surgery. The primary outcome was 1-year mortality after ICU admission. Multivariable logistic regression analysis with restricted cubic splines was used to evaluate the association between temperature and outcomes. Results:We evaluated data from 5,868 patients admitted between January 1, 2013 and May 31, 2016, including 5,311 patients (90.5%) who underwent noncardiovascular surgery and 557 patients (9.5%) who underwent cardiovascular surgery. Deviation from the median temperature (36.6°C) was associated with increases in 1-year mortality (≤ 36.6°C: linear coefficient, –0.531; P<0.001 and ≥36.6°C: spline coefficient, 0.756; P<0.001). Similar statistically significant results were observed in the noncardiovascular surgery group, but not in the cardiovascular surgery group. Conclusions:An increase or decrease in body temperature (vs. 36.6°C) measured using digital axillary thermometers within 10 minutes of postoperative ICU admission was associated with increased 1-year mortality. However, no significant association was observed after cardiovascular surgery. These results suggest that postoperative temperature is associated with longterm mortality in patients admitted to the surgical ICU in the postoperative period.
Kim, Kyong Hoon,Choi, Aryeong,Kim, Sang Hoon,Song, Heonju,Jin, Seohoon,Kim, Kyungim,Jang, Jaebong,Choi, Hanbyeul,Jung, Yong Woo Korean Society for Molecular and Cellular Biology 2021 Molecules and cells Vol.44 No.11
Memory T (T<sub>M</sub>) cells play an important role in the long-term defense against pathogen reinvasion. However, it is still unclear how these cells receive the crucial signals necessary for their longevity and homeostatic turnover. To understand how T<sub>M</sub> cells receive these signals, we infected mice with lymphocytic choriomeningitis virus (LCMV) and examined the expression sites of neural cadherin (N-cadherin) by immunofluorescence microscopy. We found that N-cadherin was expressed in the surroundings of the white pulps of the spleen and medulla of lymph nodes (LNs). Moreover, T<sub>M</sub> cells expressing high levels of killer cell lectin-like receptor G1 (KLRG1), a ligand of N-cadherin, were co-localized with N-cadherin<sup>+</sup> cells in the spleen but not in LNs. We then blocked N-cadherin in vivo to investigate whether it regulates the formation or function of T<sub>M</sub> cells. The numbers of CD127<sup>hi</sup>CD62L<sup>hi</sup> T<sub>M</sub> cells in the spleen of memory P14 chimeric mice declined when N-cadherin was blocked during the contraction phase, without functional impairment of these cells. In addition, when CD127<sup>lo</sup>KLRG1<sup>hi</sup> T<sub>M</sub> cells were adoptively transferred into anti-N-cadherin-treated mice compared with control mice, the number of these cells was reduced in the bone marrow and LNs, without functional loss. Taken together, our results suggest that N-cadherin participates in the development of CD127<sup>hi</sup>CD62L<sup>hi</sup> T<sub>M</sub> cells and homing of CD127<sup>lo</sup>KLRG1<sup>hi</sup> T<sub>M</sub> cells to lymphoid organs.
Enhanced UV stability of perovskite solar cells with a SrO interlayer
Lee, Sang-Won,Kim, Seongtak,Bae, Soohyun,Cho, Kyungjin,Chung, Taewon,Hwang, Jae-Keun,Song, Inseol,Lee, Wonkyu,Park, Sungeun,Jung, Jaebong,Chun, Jihun,Lee, Yoon Jung,Moon, Yeon Ji,Lee, Hae-Seok,Kim, Do Elsevier 2018 Organic Electronics Vol.63 No.-
<P><B>Abstract</B></P> <P>We investigated strontium oxide (SrO) as an interlayer material to enhance the UV stability of a CH<SUB>3</SUB>NH<SUB>3</SUB>PbI<SUB>3</SUB> perovskite solar cell. Moisture and over 400 nm wavelength of light were excluded to investigate the effect of UV light only. Two different interlayer fabrication processes were examined to optimize the performance of this solar cell. Devices fabricated by dipping for 30 min in SrO solution exhibited photoconversion efficiencies of 15.5%, whereas those fabricated with 60-min dipping showed photoconversion efficiencies of 15% and exhibited local Sr agglomeration. Devices with SrO displayed lower initial efficiencies than those without any SrO layer (17.6%), However, a device without SrO retained only 34.4% of its initial efficiency after 100 h of UV exposure. In contrast, SrO-incorporated devices retained almost 60.0% of their initial efficiency. Severe μ-PL mapping intensity degradation was observed in devices that did not include the interlayer, but no degradation was observed in those with the SrO interlayer. This can be attributed to the passivation of the degradation sites by SrO.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Perovskite UV stability was tested under conditions except moisture, oxygen and wavelengths exceeding 400 nm. </LI> <LI> With high resolution μ-PL mapping technique, direct evidence is provided about the area perovskite UV degradation begins. </LI> <LI> UV degradation is initiated at the ETL/perovskite interface. </LI> <LI> Effect of the SrO interlayer on UV stability was examined in an inert atmosphere. </LI> <LI> UV stability is enhanced by SrO interface passivation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>