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RISS 인기검색어
- 검색키워드
- 저자 : J. C. WASS (검색결과 3 건)
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Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Chambers, John C,Zhang, Weihua,Sehmi, Joban,Li, Xinzhong,Wass, Mark N,Van der Harst, Pim,Holm, Hilma,Sanna, Serena,Kavousi, Maryam,Baumeister, Sebastian E,Coin, Lachlan J,Deng, Guohong,Gieger, Christi Nature Publishing Group, a division of Macmillan P 2011 Nature genetics Vol.43 No.11
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10<SUP>??8</SUP> to P = 10<SUP>??190</SUP>). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function.
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ELECTROCHEMICAL PROCESSING OF USED NUCLEAR FUEL
K. M. GOFF,J. C. WASS,K. C. MARSDEN,G. M. TESKE 한국원자력학회 2011 Nuclear Engineering and Technology Vol.43 No.4
As part of the Department of Energy’s Fuel Cycle Research and Development Program an electrochemical technology employing molten salts is being developed for recycle of metallic fast reactor fuel and treatment of light water reactor oxide fuel to produce a feed for fast reactors. This technology has been deployed for treatment of used fuel from the Experimental Breeder Reactor II (EBR-II) in the Fuel Conditioning Facility, located at the Materials and Fuel Complex of Idaho National Laboratory. This process is based on dry (non-aqueous) technologies that have been developed and demonstrated since the 1960s. These technologies offer potential advantages compared to traditional aqueous separations including: compactness,resistance to radiation effects, criticality control benefits, compatibility with advanced fuel types, and ability to produce low purity products. This paper will summarize the status of electrochemical development and demonstration activities with used nuclear fuel, including preparation of associated high-level waste forms.
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ELECTROCHEMICAL PROCESSING OF USED NUCLEAR FUEL
Goff, K.M.,Wass, J.C.,Marsden, K.C.,Teske, G.M. Korean Nuclear Society 2011 Nuclear Engineering and Technology Vol.43 No.4
As part of the Department of Energy's Fuel Cycle Research and Development Program an electrochemical technology employing molten salts is being developed for recycle of metallic fast reactor fuel and treatment of light water reactor oxide fuel to produce a feed for fast reactors. This technology has been deployed for treatment of used fuel from the Experimental Breeder Reactor II (EBR-II) in the Fuel Conditioning Facility, located at the Materials and Fuel Complex of Idaho National Laboratory. This process is based on dry (non-aqueous) technologies that have been developed and demonstrated since the 1960s. These technologies offer potential advantages compared to traditional aqueous separations including: compactness, resistance to radiation effects, criticality control benefits, compatibility with advanced fuel types, and ability to produce low purity products. This paper will summarize the status of electrochemical development and demonstration activities with used nuclear fuel, including preparation of associated high-level waste forms.
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