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Nizwaside: a new anticancer pregnane glycoside from the sap of Desmidorchis flava
Hidayat Hussain,Ahmed Al-Harrasi,Muhammad Adil Raees,Najeeb Ur Rehman,Ahmed Al-Rawahi,Rene´ Csuk,Husain Yar Khan,Ghulam Abbas,Mohammed Abdullah Al-Broumi,Ivan R. Green,Ali Elyassi,Talat Mahmood 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.12
The sap from the succulent Desmidorchis flava (N.E.Br) Meve and Liede yielded a new pregnane glycoside, named nizwaside whose structure was established using 1D and 2D NMR techniques as well as mass spectrometry (ESIMS). Nizwaside was tested for anticancer, DPPH antioxidant, urease enzyme inhibition, a-glucosidase enzyme inhibition and acetylcholinesterase inhibition activities. Interestingly, nizwaside showed significant anti-proliferative effects on MDA MB231 breast cancer cells with an IC50 of 23.5 lg/ml. Moreover, nizwaside was more effective than Doxorubicin, a wellknown clinical anticancer drug, in suppressing MDA MB231 cell proliferation even at concentrations lower than that of Doxorubicin (75 lg/ml nizwaside vs. 100 lg/ml Doxorubicin). On the other hand, nizwaside showed relatively weak antioxidant activity with 15 % inhibition.
ChemInform Abstract: Antimicrobial Natural Products: An Update on Future Antibiotic Drug Candidates
Saleem, Muhammad,Nazir, Mamona,Ali, Muhammad Shaiq,Hussain, Hidayat,Lee, Yong Sup,Riaz, Naheed,Jabbar, Abdul WILEY-VCH Verlag 2010 Chem Inform Vol.41 No.21
<P>ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.</P>
Non-local orthotropic elastic shell model for vibration analysis of protein microtubules
Muhammad Taj,Afnan Majeed,Muzamal Hussain,Muhammad N. Naeem,Muhammad Safeer,Manzoor Ahmad,Hidayat Ullah Khan,Abdelouahed Tounsi 사단법인 한국계산역학회 2020 Computers and Concrete, An International Journal Vol.25 No.3
Vibrational analysis in microtubules is examined based on the nonlocal theory of elasticity. The complete analytical formulas for wave velocity are obtained and the results reveal that the small scale effects can reduce the frequency, especially for large longitudinal wave-vector and large circumferential wave number. It is seen that the small scale effects are more significant for smaller wave length. The methods and results may also support the design and application of nano devices such as micro sound generator etc. The effects of small scale parameters can increase vibrational frequencies of the protein microtubules and cannot be overlooked in the analysis of vibrating phenomena. The results for different modes with nonlocal effect are checked.
Idrees, Muhammad,Batool, Saima,Ullah, Hidayat,Hussain, Qaiser,Al-Wabel, Mohammad I.,Ahmad, Mahtab,Hussain, Amjad,Riaz, Muhammad,Ok, Yong Sik,Kong, Jie Elsevier 2018 Journal of molecular liquids Vol.266 No.-
<P><B>Abstract</B></P> <P>In the present investigation, poultry manure and farmyard manure-derived biochars were applied as cost-effective adsorbents for manganese (Mn) removal from aqueous media. Effects of functional parameters such as solution pH, contact time, temperature and concentration on the Mn removal efficiency of biochars were evaluated. Poultry manure-derived biochar exhibited greater adsorption efficiency than farmyard manure-derived biochar due to its porosity and surface functionality. The maximum adsorption was achieved at pH 6, temperature 298 K and contact time of 3 h. The adsorption isotherm data was well fitted to the Freundlich model indicating multilayer adsorption onto heterogeneous surfaces of the biochars. Thermodynamics calculations affirmed that Mn adsorption onto biochars was spontaneous and exothermic process governed by hydrogen bonding type of electrostatic interaction. Post-adsorption spectroscopic analysis of Mn-loaded biochars evidenced the binding of Mn with active surface functionalities of biochars.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Biochar, a by-product of pyrolysis, was prepared as a low cost adsorbent precursor. </LI> <LI> Effect of derived biochars on Manganese removal efficiency was investigated. </LI> <LI> FBC and PBC characteristics were analyzed. </LI> <LI> Langmuir and Freundlich models were used for equilibrium modeling. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>