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- 저자 : Hajar Moghadas (검색결과 1 건)
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Oxidized gum arabic cross-linked pectin/O-carboxymethyl chitosan: An antibiotic adsorbent hydrogel
Reza Darvishi,Hajar Moghadas,Ali Moshkriz 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.5
The current work investigated the synthesis possibility of oxidized gum arabic cross-linked pectin/O-carboxymethylchitosan hydrogels (OGA-Pc-O-CMCS) as a pH-sensitive adsorbent vehicle. During the hydrogel fabrication,the cross-linker oxidized gum arabic (OGA) plays an important role in the enhancement of mechanical stabilityand the structural compactness of the hydrogel. The effect of OGA content, reaction time, reaction temperature, andreaction pH on the hydrogel swelling and crosslink degree was evaluated, modeled, and optimized statistically usingresponse surface methodology (RSM) based on central composite design (CCD). As the pH of pectin/O-Carboxymethylchitosan (Pc-O-CMCS) complexation increased up to 6.0, the swelling degree of the hydrogels decreased regardless ofthe concentration of the OGA. The swelling indices of 101.35% and 70.552% showed the optimum RSM results in theacidic and neutral medium, respectively. The adsorption efficiency of two conventional fluoroquinolones antibiotics(Levofloxacin (LVX) and Delafloxacin (DLX)) in the optimized hydrogel formulations was investigated. The obtainedresults confirmed that OGA concentration was an important parameter in the swelling processes. The adsorptioncapacity of the hydrogels was higher in acidic medium (pH 3.9) compared to natural medium (pH 7.1), which indicatesthe pH-sensitive adsorption behavior of the prepared hydrogel. The maximum antibiotic adsorption occurredafter 12 hours: (66.3-87.5%) and (45-53%) for pH 3.9 and 7.1, respectively. The shape and morphological analysis ofthe beads before and after adsorption was performed using field emission scanning electron microscopy (FE-SEM). The FE-SEM analysis revealed that the shape of the beads changed significantly because of erosion and swelling activityafter antibiotics adsorption. Experimental results exhibited that SIP model fitted best to the isotherm adsorption ofLVX and DLX onto OGA-Pc-O-CMCS hydrogel.
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