http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Guettier, Jean-Marc (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Li, Jian H.,Gautam, Dinesh,Han, Sung-Jun,Guettier, Jean-Marc,Cui, Yinghong,Lu, Huiyan,Deng, Chuxia,O'Hare, James,Jou, William,Gavrilova, Oksana,Buettner, Christoph,Wess, Jü,rgen American Diabetes Association 2009 Diabetes Vol.58 No.12
<P><B>OBJECTIVE</B></P><P>An increase in the rate of hepatic glucose production is the major determinant of fasting hyperglycemia in type 2 diabetes. A better understanding of the signaling pathways and molecules that regulate hepatic glucose metabolism is therefore of great clinical importance. Recent studies suggest that an increase in vagal outflow to the liver leads to decreased hepatic glucose production and reduced blood glucose levels. Since acetylcholine (ACh) is the major neurotransmitter of the vagus nerve and exerts its parasympathetic actions via activation of muscarinic ACh receptors (mAChRs), we examined the potential metabolic relevance of hepatocyte mAChRs.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>We initially demonstrated that the M<SUB>3</SUB> mAChR is the only mAChR subtype expressed by mouse liver/hepatocytes. To assess the physiological role of this receptor subtype in regulating hepatic glucose fluxes and glucose homeostasis in vivo, we used gene targeting and transgenic techniques to generate mutant mice lacking or overexpressing M<SUB>3</SUB> receptors in hepatocytes only.</P><P><B>RESULTS</B></P><P>Strikingly, detailed in vivo phenotyping studies failed to reveal any significant metabolic differences between the M<SUB>3</SUB> receptor mutant mice and their control littermates, independent of whether the mice were fed regular or a high-fat diet. Moreover, the expression levels of genes for various key transcription factors, signaling molecules, and enzymes regulating hepatic glucose fluxes were not significantly altered in the M<SUB>3</SUB> receptor mutant mice.</P><P><B>CONCLUSIONS</B></P><P>This rather surprising finding suggests that the pronounced metabolic effects mediated by activation of hepatic vagal nerves are mediated by noncholinergic signaling pathways.</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
