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Firoz Anwar,Rajbala Singh,Gohar Mushtaq,Abdul Rehman Al-Maliki,Abdullah Sabih,F. A. Al-Abbasi,Aftab Ahmad,Muhammad Afzal,Imran Kazm,Ruqaiyah Kha 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.3
Hepatocellular carcinoma (HCC) is the fifth and third most common cause of cancer-related deaths. Erythrosine, a commonly used coloring agent in tablet preparation was studied for its role when supplemented with sub necrotic dose of DENA (n-diethyl nitrosamine) to induced HCC in Wistar rats. Single dose of chemical carcinogen DENA with intraperitoneal injection (20 mg/kg) administered before Erythrosine at a dose 0.014 mg/kg by p.o, DENA treated rats and alone. Exposure of DENA and Erythrosine alters the levels of Serum glutamate oxaloacetate transaminase (SGO T), Serum glutamate pyrophosphate transaminase (SGPT), Alkaline phosphate (ALP), Total Bilirubin (TBR), Blood uric acid, urea, lipid profile and Serum alpha-feto protein (AFP) in Wistar rats, with further alteration in intracellular antioxidant enzyme profile Lipid Per oxidation (LPO), Glutathione Peroxidase (GPx), Melanoaldehyde (MDA), Glutathione Reductase (GR), Catalase (CAT), Glutathione (GSH), Glutathione- S-Transferase (GST), Superoxide Dismutase (SOD) along with Vit. C and Vit. E conc.. Moreover Histopathological examinations of the liver tissue showed marked effect of DENA and Erythrosine exposure on liver structure. The results concluded that Erythrosine used as coloring agent for tablet coating as well as food colorant in India, was found to be an inducer as liver proliferating agent and promoter of HCC.
Ahmad, Khurshid,Baig, Mohammad Hassan,Mushtaq, Gohar,Kamal, Mohammad Amjad,Greig, Nigel H.,Choi, Inho Bentham Science 2017 Current Alzheimer research Vol.14 No.11
<P>Conclusion: The studies concentrating on the commonalities in biological pathways, cellular mechanisms and genetics may provide the scope to researchers to identify few novel common target(s) for disease prevention and development of effective common drugs for multi-neurodegenerative diseases.</P>