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RISS 인기검색어
- 검색키워드
- 저자 : Goedhart, Geertje (검색결과 3 건)
- 무료
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Shear induced damage of red blood cells monitored by the decrease of their deformability
안경현,이성식,이승종,선경,Petrus T. Goedhart,Max. R. Hardeman 한국유변학회 2004 Korea-Australia rheology journal Vol.16 No.3
Shear-induced damage of Red Blood Cell (RBC) is an imminent problem to be solved for the practical application of artificial organs in extra corporeal circulation, as it often happens and affects physiological homeostasis of a patient. To design and operate artificial organs in a safe mode, many investigations have been set up to correlate shear and shear-induced cell damage. Most studies were focused on hemolysis i.e. the extreme case, however, it is important as well to obtain a clear understanding of pre-hemolytic mechanical damage. In this study, the change in deformability of RBC was measured by ektacytometry to investigate the damage of RBC caused by shear. To a small magnitude of pre-shear, there is little difference, but to a large magnitude of pre-shear, cell damage occurs and the effect of shear becomes significant depending on both the magnitude and imposed time of shearing. The threshold stress for cell damage was found to be approximately 30 Pa, which is much less than the threshold of mechanical hemolysis but is large enough to occur in vitro as in the extra corporeal circulation during open-heart surgery or artificial heart. In conclusion, it was found and suggested that the decrease of deformability can be used as an early indication of cell damage, in contrast to measuring plasma hemoglobin. As cell damage always occurs during flow in artificial organs, the results as well as the approach adopted here will be helpful in the design and operation of artificial organs.
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Shear induced damage of red blood cells monitored by the decrease of their deformability
Lee, Sung Sik,Ahn, Kyung Hyun,Lee, Seung Jong,Sun, Kyung,Goedhart, Petrus T.,Hardeman, Max. R. The Korean Society of Rheology 2004 Korea-Australia rheology journal Vol.16 No.3
Shear-induced damage of Red Blood Cell (RBC) is an imminent problem to be solved for the practical application of artificial organs in extra corporeal circulation, as it often happens and affects physiological homeostasis of a patient. To design and operate artificial organs in a safe mode, many investigations have been set up to correlate shear and shear-induced cell damage. Most studies were focused on hemolysis i.e. the extreme case, however, it is important as well to obtain a clear understanding of pre-hemolytic mechanical damage. In this study, the change in deformability of RBC was measured by ektacytometry to investigate the damage of RBC caused by shear. To a small magnitude of pre-shear, there is little difference, but to a large magnitude of pre-shear, cell damage occurs and the effect of shear becomes significant depending on both the magnitude and imposed time of shearing. The threshold stress for cell damage was found to be approximately 30 Pa, which is much less than the threshold of mechanical hemolysis but is large enough to occur in vitro as in the extra corporeal circulation during open-heart surgery or artificial heart. In conclusion, it was found and suggested that the decrease of deformability can be used as an early indication of cell damage, in contrast to measuring plasma hemoglobin. As cell damage always occurs during flow in artificial organs, the results as well as the approach adopted here will be helpful in the design and operation of artificial organs.
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Patterns of cellular phone use among young people in 12 countries: Implications for RF exposure
Langer, Chelsea E.,de Llobet, Patricia,Dalmau, Albert,Wiart, Joe,Goedhart, Geertje,Hours, Martine,Benke, Geza P.,Bouka, Evdoxia,Bruchim, Revital,Choi, Kyung-Hwa,Eng, Amanda,Ha, Mina,Karalexi, Maria,Ki Elsevier 2017 Environment international Vol.107 No.-
<P><B>Abstract</B></P> <P>Characterizing exposure to radiofrequency (RF) fields from wireless telecommunications technologies during childhood and adolescence is a research priority in investigating the health effects of RF. The Mobi-Expo study aimed to describe characteristics and determinants of cellular phone use in 534 young people (10–24years) in 12 countries. The study used a specifically designed software application installed on smartphones to collect data on the use of wireless telecommunications devices within this age group. The role of gender, age, maternal education, calendar period, and country was evaluated through multivariate models mutually adjusting for all variables. Call number and duration were higher among females compared to males (geometric mean (GM) ratio 1.17 and 1.42, respectively), among 20–24year olds compared to 10–14year olds (GM ratio 2.09 and 4.40, respectively), and among lowest compared to highest social classes (GM ratio 1.52 and 1.58, respectively). The number of SMS was higher in females (GM ratio 1.46) and the middle age group (15–19year olds: GM ratio 2.21 compared to 10–14year olds) and decreased over time. Data use was highest in the oldest age group, whereas Wi-Fi use was highest in the middle age group. Both data and Wi-Fi use increased over time. Large differences in the number and duration of calls, SMS, and data/Wi-Fi use were seen by country, with country and age accounting for up to 50% of the variance. Hands-free and laterality of use did not show significant differences by sex, age, education, study period, or country. Although limited by a convenience sample, these results provide valuable insights to the design, analysis, and interpretation of future epidemiological studies concerning the health effects of exposure resulting from cellular phone use in young people. In addition, the information provided by this research may be used to design strategies to minimize RF exposure.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Number and duration of calls varied by sex, age range, and socioeconomic status </LI> <LI> Laterality and hands-free use were less influenced by user characteristics </LI> <LI> Country of origin explained most of the variance in number and duration of calls, as well as SMS and data/Wi-Fi </LI> </UL> </P>
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