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- 저자 : Ghiso, Jorge (검색결과 2 건)
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Biology of Aβ Amyloid in Alzheimer's Disease
Grangione, Blas,Ghiso, Jorge,Wisniewski, Thomas 한림대학교 한림과학원 부설 환경ㆍ생명과학연구소 1998 국제학술회의 Vol.1998 No.-
The genetic associations with the pathological features of AD are diverse: A rapidly growing number of mutations in presenilin 1 and 2 on chromosomes 14 and 1, respectively, are found in many early-onset FAD patients (Lendon et at., 1997). In addition, βPP mutations are found in a small percentage of early-onset FAD kindreds. The apoE4 allele on chromosome 19 is associated with the presence of the most common form of AD, sporadic AD (Winsiewski & Frangione, 1992; Namba et al., 1991). However, it is clear that other proteins are also involved in the pathogenesis of AD, since some early-onset FAD kindreds do not have linkage to PS1, PS2, apoE, or βPP, while at least 50% of late-onset AD is unrelated to apoE. Other proteins which have been implicated in the formation of senile plaques, but so far are not known to have any genetic linkage to AD, include proteoglycans (Snow et al., 1987), apoA1(Wisniewski et al., 1995a), α₁-antichymotrypsin(Abraham et al., 1988), HB-GAM(Wisniewski et al., 1996a), complement components (McGeer & Rogers, 1992), acetylcholinesterase (Friede, 1965), and NAC (Ueda et al., 1993). Which of these proteins will be the most important for the etilogy of the most common form of AD, late-onset sporadic AD, remains an open question. Three of the genes which are now known to be linked to AD, including PS1, βPP, and apoE, have been established immunohistochemically and biochemically to be components of senile plaques (see Fig.1). This raises at least two possibilities; either each of these proteins is part of one pathway with Aβ-related amyloid formation as a final causative pathogenic event or amyloid deposition in AD is a reactive process related to dysfunction of a number of different CNS proteins. Whether or not amyloid formation is directly causative in the pathogenesis of AD, current data suggest that new therapeutic approaches which may inhibit the aggregation and/or the conformational change of sAβ to Aβ fibrils (Soto et al., 1996) have the greatest likelihood to make a significant impact on controlling amyloid accumulation in AD.
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Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, Daniel J.,Abdalla, Fabio C.,Abeliovich, Hagai,Abraham, Robert T.,Acevedo-Arozena, Abraham,Adeli, Khosrow,Agholme, Lotta,Agnello, Maria,Agostinis, Patrizia,Aguirre-Ghiso, Julio A.,Ahn, Hyung Taylor and Francis 2012 Autophagy Vol.8 No.4
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