HPMA copolymer-cyclic RGD Conjugates for Imaging and Targeted Drug Delivery to Sites of Tumor Angiogenesis

Hamid Ghandehari 한국고분자학회 2011 한국고분자학회 학술대회 연구논문 초록집 Vol.2011 No.1

Employing GDQ method for exploring undamped vibrational performance of CNT-reinforced porous coupled curved beam

Moein A. Ghandehari,Amir R. Masoodi Techno-Press 2023 Advances in nano research Vol.15 No.6

Coupled porous curved beams, due to their low weight and high flexibility, have many applications in engineering. This study investigates the vibration behavior of coupled porous curved beams in different boundary conditions. The system consists of two curved beams connected by a mid-layer of elastic springs. These beams are made of various materials, such as homogenous steel foam, and composite materials with PMMA (polymethyl methacrylate) and SWCNT (single-walled carbon nanotube) used as the matrix and nanofillers, respectively. To obtain equivalent material properties, the role of mixture (RoM) was employed, followed by the implementation of the porosity function. The system's governing equations were obtained by employing FSDT and Hamilton's law. To investigate thermal vibration, temperature was implemented as a load in the governing equations. The GDQ method was used to solve these equations. To demonstrate the applicability of the GDQ method in calculating the frequencies of the system and the correctness of the developed program, a validation study was conducted. After validation, numerous examples were presented to investigate the behavior of single and coupled curved beams in various material properties and boundary conditions. The results indicate that the frequencies of the curved beams and the system depend highly on the amount of porosity (n) and the distribution pattern. The system frequencies decreased with an increase in the porosity coefficient. The stiffness of the springs had no effect on the first mode frequency but increased frequencies of other modes in a specific range. The frequencies of the system decreased with an increase in environmental temperature.

Project scheduling by FGP to Time-Cost-Quality trade off: construction case study

Faregh, Najmeh,Ketabi, Saeedeh,Ghandehari, Mahsa Korea Institute of Construction Engineering and Ma 2014 Journal of construction engineering and project ma Vol.4 No.3

Project managers are responsible to conduct project on time with least amount of costs and the most possible quality with respect to shortage of resources and environmental certainties. They have to make the best decision to reach such conflicting objects. In this study the project scheduling with multi goals-multi modes was planned in fuzzy conditions under resource constraints and expanded by fuzzy goal programing (FGP). The project cost was calculated by the price of renewable resources and the quality criteria were evaluated by the quality function deployment method (QFD). Finally the model was verified by a construction case study with 22 activities along with solving by GAMS. The results showed that this model could provide a systematic framework to facilitate the decision making process and made the project managers to be able to schedule the project closer to reality.

Strain-Dependent Constitutive Modelling of AZ80 Magnesium Alloy Containing 0.5 wt% Rare Earth Elements and Evaluation of Its Validation Using Finite Element Method

Mahzad Zohoori Tali,Mohammad Mazinani,Mahmoud Reza Ghandehari Ferdowsi,Gholam Reza Ebrahimi,Mohammad Marvi-Mashhadi 대한금속·재료학회 2014 METALS AND MATERIALS International Vol.20 No.6

In order to evaluate the hot flow behaviour of AZ80 magnesium alloy containing 0.5 wt% rare earth elements,isothermal hot compression tests were conducted at the temperatures range of 250-450 °C under the strainrates of 0.001-1 s1. The flow curves exhibited a peak stress at a small applied strain after which the flowstresses decrease gradually to a steady state flow stress at higher applied strain values representing theoccurrence of dynamic recrystallization. Moreover, the material constants in the Zener-Hollomon constitutiveequation were found to be strain dependent, and the relationships between these parameters and theapplied true strain were well described by fourth-degree polynomial functions. Accordingly, a strain-dependentmodel was developed in order to predict the hot flow behaviour of AZ80+0.5RE magnesium alloy. The truestresses predicted by this model were found to be in good agreements with the experimental results. Furthermore,the constitutive model developed using the experimental results was incorporated in the finiteelement model with which the hot compressive flow curve of the investigated material was modeled. Theresults showed that the accuracy of flow curves calculated by the numerical simulations depends on theaccuracy of the developed model. In order to evaluate the hot flow behaviour of AZ80 magnesium alloy containing 0.5 wt% rare earth elements,isothermal hot compression tests were conducted at the temperatures range of 250-450 °C under the strainrates of 0.001-1 s1. The flow curves exhibited a peak stress at a small applied strain after which the flowstresses decrease gradually to a steady state flow stress at higher applied strain values representing theoccurrence of dynamic recrystallization. Moreover, the material constants in the Zener-Hollomon constitutiveequation were found to be strain dependent, and the relationships between these parameters and theapplied true strain were well described by fourth-degree polynomial functions. Accordingly, a strain-dependentmodel was developed in order to predict the hot flow behaviour of AZ80+0.5RE magnesium alloy. The truestresses predicted by this model were found to be in good agreements with the experimental results. Furthermore,the constitutive model developed using the experimental results was incorporated in the finiteelement model with which the hot compressive flow curve of the investigated material was modeled. Theresults showed that the accuracy of flow curves calculated by the numerical simulations depends on theaccuracy of the developed model.

Relationship between Work-family Conflict Management and the Job Satisfaction of Iranian International Taekwondo Referees

( Somayyeh Ayenehchi ),( Mohammad Reza Esmaeil Zade Ghandehari ) 국제태권도학회 2017 International Symposium for Taekwondo Studies Vol.2017 No.-

Purpose: This paper aims to investigate the relationship between work-family conflict management and job satisfaction in Iranian International Taekwondo Referees. Methods: The study population included all the active Iranian international Taekwondo referees judging in internal and external tournaments from 2016 to 2017. The total population was 203 referees (154 male, 49 female), but our sample consisted of 105 male and 44 female referees, selected based on Morgan’s sample size table and stratified sampling method. Results: Based on the test results; there is no significant relationship between work-family conflict and job satisfaction of the Iranian international Taekwondo referees (p > 0.05). On the basis of variance analysis between work-family conflict and job satisfaction of the Iranian international Taekwondo referees considering the gender characteristics, no significant relationship was found (p > 0.05). However, there was a significant relationship between work-family conflict and job satisfaction of the Iranian international Taekwondo referees and individual work and marital status characteristics (p > 0.05). Conclusions: Iranian international Taekwondo referees spend a lot of time on becoming professionals. Thus, Iran Taekwondo Federation’s failure to pay due attention to them and create career development opportunities for them results in the referees’ decreased loyalty to their jobs. Therefore, Iranian international Taekwondo referees will have job satisfaction when they are ensured of having job security, appropriate incomes, and suitable retirement insurance.

Mild Hyperthermia Induced by Gold Nanorod-Mediated Plasmonic Photothermal Therapy Enhances Transduction and Replication of Oncolytic Adenoviral Gene Delivery

Jung, Bo-Kyeong,Lee, Yeon Kyung,Hong, JinWoo,Ghandehari, Hamidreza,Yun, Chae-Ok American Chemical Society 2016 ACS NANO Vol.10 No.11

<P>Oncolytic adenovirus (Ad) is a promising candidate for cancer gene therapy. However, as a monotherapy, it has shown insufficient therapeutic efficacy in clinical trials. In this work, we demonstrate that gold nanorod (GNR)-mediated mild hyperthermia enhances the cellular uptake and consequent gene expression of oncolytic Ad to head and neck tumor cells. We examined the combination of oncolytic Ad expressing vascular endothelial growth factor promoter-targeted artificial transcriptional repressor zinc-finger protein and GNR-mediated mild hyperthermia to improve antitumor effects. The in vitro mechanisms of increased transduction in the presence and absence of hyperthermia were explored followed by evaluation of efficacy of this combination strategy in an animal model. Exposure to optimized hyperthermia conditions improved endocytosis of oncolytic Ad, transgene expression, viral replication, and subsequent cytolysis of head and neck cancer cells. GNR-mediated plasmonic photothermal therapy resulted in precise control of tumor temperature and induction of mild hyperthermia. A combination of oncolytic Ad and GNRs resulted in potent tumor growth inhibition of head and neck tumors.</P>

Direct Observation of Interactions of Silk-Elastinlike Protein Polymer with Adenoviruses and Elastase

Jung, Se-Hui,Choi, Joung-Woo,Yun, Chae-Ok,Kim, Sun Hwa,Kwon, Ick Chan,Ghandehari, Hamidreza American Chemical Society 2015 MOLECULAR PHARMACEUTICS Vol.12 No.5

<P>Silk-elastinlike protein polymer (SELP) hydrogels have been investigated for sustained local delivery of adenoviral gene carriers to solid tumors. These polymers degrade in the presence of proteases such as elastase. A detailed understanding of the interaction of SELPs with viruses and their degradation in the presence of elastase can provide useful information about mechanisms of sustained gene delivery from these systems. In this work, we investigated the interactions of SELPs with adenoviruses (Ads) and elastase using atomic force microscopy. We observed that viral particles interacted strongly with SELP networks formed by cross-linking of nanofibers. The presence of viruses contributed to enhanced network formation. Incubation of Ad with SELPs in the liquid state induced close packing of the viral colony. Morphological changes of SELP networks cleaved by enzymatic interaction with elastase were investigated. SELP-415K fiber networks were more responsive to temperature changes and were slowly degraded by elastases compared to SELP-47K, a SELP analogue with shorter elastin units in the monomer repeat. These studies provide insight into the influence of SELP structure on degradation and potential mechanisms of increased viral stability.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/mpohbp/2015/mpohbp.2015.12.issue-5/acs.molpharmaceut.5b00075/production/images/medium/mp-2015-00075g_0008.gif'></P>