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RISS 인기검색어
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- 저자 : George Karamanolis (검색결과 1 건)
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Alexandra Argyrou,Evangelia Legaki,Christos Koutserimpas,Maria Gazouli,Ioannis Papaconstantinou,George Gkiokas,George Karamanolis 대한소화기 기능성질환∙운동학회 2019 Journal of Neurogastroenterology and Motility (JNM Vol.25 No.3
Background/AimsGastroesophageal reflux disease (GERD) represents a common condition having a substantial impact on the patients’ quality of life, aswell as the health system. According to many studies, the BARX1 and ADAMTS17 genes have been suggested as genetic risk loci forthe development of GERD and its complications. The purpose of this study is to investigate the potential association between GERDand BARX1 and ADAMTS17 polymorphisms. MethodsThe present is a prospective cohort study of 160 GERD patients and 180 healthy control subjects of Greek origin, examined for BARX1and ADAMTS17 polymorphisms (rs11789015 and rs4965272) and a potential correlation to GERD. ResultsThe rs11789015 AG and GG genotypes were found to be significantly associated with GERD (P = 0.032; OR, 1.65; 95% CI, 1.06-2.57 and P = 0.033; OR, 3.00; 95% CI, 1.15-7.82, respectively), as well as the G allele (P = 0.007; OR, 1.60; 95% CI, 1.14- 2.24). Concerning the rs4965272, only the GG genotype was significantly associated with GERD (P = 0.035; OR, 3.42; 95% CI, 1.06-11.05). ConclusionsThis is a study investigating the potential correlation between BARX1 and ADAMTS17 polymorphisms and the development ofGERD, showing a considerable association between both polymorphisms and the disease. This finding suggests that esophagealdifferentiation or altered regulation on microfibrils in the cell environment could be implicated as possible mechanisms in thepathogenesis of GERD.
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