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- 저자 : Feng Yuchen (검색결과 4 건)
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Liu Na,Feng Yuchen,Liu Huicheng,Wu Wenliang,Liang Yuxia,Li Pingfei,Wei Zhengping,Wu Min,Tang Zhao-Hui,Han Junyan,Cheng Xiang,Liu Zheng,Laurence Arian,Li Huabin,Zhen Guohua,Yang Xiang-Ping 대한천식알레르기학회 2021 Allergy, Asthma & Immunology Research Vol.13 No.3
Purpose Macrophages are important regulators of environmental allergen-induced airway inflammation and asthma. ATP6V0d2 is a subunit of vacuolar ATPase highly expressed in macrophages. However, the functions of ATP6V0d2 in the regulation of pathogenesis of allergic asthma remain unclear. The aim of this study is to determine the function and related molecular mechanisms of macrophage protein ATP6V0d2 in allergic asthma. Methods We compared the disease severity between female C57BL/6 wild-type and ATP6V0d2−/− mice in an ovalbumin (OVA)-induced asthma model. We also investigated the association of expression of ATP6V0d2, PU.1 and CCL17 with disease severity among asthmatic patients. Results The expression of ATP6V0d2 in sputum cells of asthmatic patients and in the lungs of OVA-challenged mice was enhanced compared to healthy subjects and their counterparts, respectively. However, ATP6V0d2-deficient mice exaggerated inflammatory cell infiltration as well as enhanced alternative activated macrophage (AAM) polarization and mucus production in an OVA-induced asthma model. Furthermore, we found that Atp6v0d2 promoted lysosomal degradation of Pu.1, which induced AAM polarization and Ccl17 production. Among asthma patients, ATP6V0d2 expression was inversely associated with disease severity, whereas PU.1 and CCL17 expression was positively associated with disease severity. Conclusions Our results identify macrophage Atp6v0d2, as an induced feedback inhibitor of asthma disease severity by promoting Pu.1 lysosomal degradation, which may in turn leads to reduced AAM polarization and Ccl17 production.
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Seismic behavior of energy dissipation shear wall with CFST column elements
Hao Su,Lihua Zhu,Yaohong Wang,Lei Feng,Zeyu Gao,Yuchen Guo,Longfei Meng,Hanquan Yuan 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.43 No.1
To develop high-efficiency lateral force resistance components for high-rise buildings, a novel energy dissipation shear wall with concrete-filled steel tubular (CFST) column elements was proposed. An energy dissipation shear wall specimen with CFST column elements (GZSW) and an ordinary reinforced concrete shear wall (SW) were constructed, and experimented by low-cycle reversed loading. The mechanical characteristics of these two specimens, including the bearing capacity, ductility, energy dissipation, and stiffness degradation process, were analyzed. The finite-element model of the GZSW was established by ABAQUS. Based on this finite-element model, the effect of the placement of steel-plate energy dissipation connectors on the seismic performance of the shear wall was analyzed, and optimization was performed. The experiment results prove that, the GZSW exhibited a superior seismic performance in terms of bearing capacity, ductility, energy dissipation, and stiffness degradation, in comparison with the SW. The results calculated by the ABAQUS finite-elements model of GZSW corresponded well with the results of experiment, and it proved the rationality of the established finite-elements model. In addition, the optimal placement of the steel-plate energy dissipation connectors was obtained by ABAQUS.
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Yu Chen,Ran Feng 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.3
This paper presents an experimental investigation on concrete-fi lled double-skin circular hollow section (CHS) cross joints under axial compression. A total of twenty-two right-angled CHS cross joints with diff erent brace to chord diameter ratio ( β ), inner tube to outer tube thickness ratio of chord ( ω ) and hollow ratio of chord ( χ ) were tested, in which eighteen concretefi lled double-skin CHS cross joints were studied for diff erent shapes of inner tube of chord, two traditional empty CHS cross joints and two traditional concrete-fi lled CHS cross joints were tested for comparison. The joint strengths, failure modes, load-deformation curves and strain distribution curves of all specimens are reported. The eff ects of brace to chord diameter ratio ( β ), inner tube to outer tube thickness ratio of chord ( ω ), hollow ratio of chord ( χ ), shape of inner tube of chord and concrete strength on the behaviour of concrete-fi lled double-skin CHS cross joints under axial compression were evaluated. It is shown from the comparison that the ultimate load and initial stiff ness of CHS cross joints are signifi cantly enhanced by strengthening the chord member with inner tube and concrete infi ll. Furthermore, the ultimate strengths are increased with the increase of the β ratio, whereas the ultimate strengths are decreased with the increase of the χ ratio for all types of concrete-fi lled double-skin CHS cross joints. On the other hand, the ultimate strengths are enhanced with the increase of the ω ratio and concrete strength for all types of concrete-fi lled double-skin CHS cross joints, but the enhancement is insignifi cant. The corresponding fi nite element analysis was also performed and calibrated against the test results. The design equations are proposed based on the test and fi nite element analysis results for concrete-fi lled double-skin CHS cross joints, which are verifi ed to be more accurate.
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A Survey of Remote Data Integrity Checking: Techniques and Verification Structures
Yu Chen,Feng Wang,Liehuang Zhu,Zijian Zhang 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.4
Cloud storage offers clients great convenience to relieve them from heavy burden of storage and management, so an increasing number of clients choose to outsource their data to remote cloud providers. However, for clients, this entails a sacrifice of actual control of these files. Remote servers may suffer from disk failure for uncertain reasons or even delete rarely accessed data to sell these storages to other clients. Therefore, there’s a great necessity for clients to make sure that their data are well stored in remote servers. Numbers of remote integrity checking (RIC) schemes are proposed to solve issues above, including following up work Provable Data Possession (PDP) and Proofs of Retrievability (PoR), which can be applied in cloud auditing. This paper presents state-of-the-art RIC schemes and makes a classification from the perspective of whether they support dynamic verifications, i.e., whether they can still be used to make verifications after clients modify, insert or delete files. In static verification schemes, we delve into the mechanisms and techniques used for integrity checking. For dynamic ones, we discuss the authentication structures that support dynamic operations. We also present several remarks to guide readers to a wide vision of data checking as conclusions and future work.
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