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RISS 인기검색어
- 검색키워드
- 저자 : Fatemeh Farjadian (검색결과 2 건)
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Assessment of pH Responsive Delivery of Methotrexate Based on PHEMA-st-PEG-DA Nanohydrogels
Javad Farzanfar,Fatemeh Farjadian,Amir Roointan,Soliman Mohammadi-Samani,Lobat Tayebi 한국고분자학회 2021 Macromolecular Research Vol.29 No.1
Nanohydrogels (NHs) are novel and attractive carriers for various anticancer factors delivery. The objective of present study is development of a safe NH for pH responsive delivery of methotrexate (MTX). Herein, poly (hydroxyethyl methacrylate) is utilized as the main structure, which is cross-linked with poly(ethyleneglycol) diacrylate (PEG-DA) through reversible addition fragmentation chain transfer polymerization technique. After synthesis, the developed structure is characterized using different methods, including 1H NMR, FT-IR, size exclusion chromatography, transmission electron microscopy and dynamic light scattering. The results confirm successful synthesis of the NH with acceptable yield and nano scale mean size of 194 nm. Methotrexate is conjugated with the aforementioned structure through pH responsive esteric bond. The efficiency of the prepared NH in loading and release of the anticancer drug, methotrexate, is tested. The developed NH shows great potential in methotrexate loading, as well as a faster release rate of methotrexate in acidic pH. The results of in vitro toxicity assessment on MCF-7 as a breast cancer cell line reveal an improved cytotoxicity induction by the methotrexate loaded particles when compared with the free MTX molecules. The suitable size (<200 nm), great potential in loading and release of the methotrexate and cytotoxicity induction in cancer cells are the reliable features of NH as an ideal anti-cancer vehicle.
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Soheila Ghasemi,Marzieh Owrang,Farzad Javaheri,Fatemeh Farjadian 한국고분자학회 2022 Macromolecular Research Vol.30 No.5
Poly(N-isopropylacrylamide) (PNIPAAm) hydrogel as a temperatureresponsive polymer was prepared through controlled process using reversible addition fragmentation chain transfer (RAFT) polymerization. The hydrogel was then amino modified using a biocompatible polyamine i.e. spermine and next the antitumor cisplatin drug was conjugated to the modified hydrogel via pH-sensitive spermine linkage. This system had a pH dependency and temperature sensitivity at lower critical solution temperature (LCST). Cisplatin potentially is liberated from the carrier in the acidic environment. However, the release of cisplatin from this polymeric system is increased considerably around the transition temperature of the polymer. The drug release manner of the prepared hydrogel was determined at two pH values (5.5 and 7.4) and three temperatures (37, 40 and 42℃) at different time intervals. The in vitro toxicity assessment was conducted on MCF-7 cell line which showed the system efficiency in killing breast cancer cells.
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