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RISS 인기검색어
- 검색키워드
- 저자 : F. Moztarzadeh (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Evaluation of a prepared sol-gel bioactive glass fiber-reinforced calcium phosphate cement
N. Nezafati,F. Moztarzadeh,S. Hesaraki 한양대학교 세라믹연구소 2010 Journal of Ceramic Processing Research Vol.11 No.3
In this article 5-25 V% of a sol-gel bioglass fiber was incorporated into calcium phosphate bone cement to improve its mechanical properties. Compressive strength, work of fracture, elastic modulus and setting time of the cement were investigated as well as phase changes occurring during soaking the specimens in simulated body fluid (SBF). The cement microstructure was also observed by scanning electron microscope (SEM). The results showed that the compressive strength of the set cements without any fibers was 0.635 MPa which was optimally increased to 3.69 MPa by using 15% fibers and then decreased by further addition of the glass phase. In addition, both the work-of-fracture and elastic modulus of the cement were considerably increased when using the fibers in the cement composition. Setting time slightly decreased by using the fibers. A considerable content of the reactants in both fiber-free and fiber-containing cements were transformed to the apatite phase during soaking sample in SBF.
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Preparation of hydroxyapatite ceramics for biomedical applications
M. Haghbin Nazarpak,F. Moztarzadeh,M. Solati-Hashjin 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.1
Hydroxyapatite (HA) is the main component of hard tissue and because of its high biocompatibility and bioactivity makes a strong bond with hard tissue. In this research, hydroxyapatite powders were uniaxially compacted at 86 MPa to form cylindrical shaped samples and sintered at 700-1300℃ with one hour soaking time. The density measured was between 2.89 and 3.49 g/cm³. Phase analyses were performed using X- ray diffraction and the results revealed there was no sign of HA decomposition. Three and four point bending strengths were measured between 7 to 44 MPa. Microstructural studies with a scanning electron microscope (SEM) showed that hydroxyapatite ceramics formed a highly integrated structure with an increase in the sintering temperature up to 1300℃. It was proved that the sintered samples of hydroxyapatite did not contain any unwanted phase. These results imply that the blocks prepared in this study have the potential for use as biomedical implants. Hydroxyapatite (HA) is the main component of hard tissue and because of its high biocompatibility and bioactivity makes a strong bond with hard tissue. In this research, hydroxyapatite powders were uniaxially compacted at 86 MPa to form cylindrical shaped samples and sintered at 700-1300℃ with one hour soaking time. The density measured was between 2.89 and 3.49 g/cm³. Phase analyses were performed using X- ray diffraction and the results revealed there was no sign of HA decomposition. Three and four point bending strengths were measured between 7 to 44 MPa. Microstructural studies with a scanning electron microscope (SEM) showed that hydroxyapatite ceramics formed a highly integrated structure with an increase in the sintering temperature up to 1300℃. It was proved that the sintered samples of hydroxyapatite did not contain any unwanted phase. These results imply that the blocks prepared in this study have the potential for use as biomedical implants.
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Mechanical Behavior of a New Biphasic Calcium Phosphate Bone Graft
S. M. Rabiee,S. M. J. Mortazavi,F. Moztarzadeh,D. Sharifi,Sh. Sharifi,M. Solati-Hashjin,H. Salimi-Kenari,D. Bizari 한국생물공학회 2008 Biotechnology and Bioprocess Engineering Vol.13 No.2
The aim of this study was to create a new porous calcium phosphate implant for use as a synthetic bone graft substitute. Porous bioceramic was fabricated using a foam-casting method. By using polyurethane foam and a slurry containing hydroxyapatite-dicalcium phosphate powder, water, and additives, a highly porous structure (66 ± 5%) was created. The porous specimens possess an elastic modulus of 330 ± 32 MPa and a compressive strength of 10.3 ± 1.7 MPa. The X-ray diffraction patterns show hydroxyapatite and beta-pyrophosphate phases after sintering. A rabbit model was developed to evaluate the compressive strength and elastic modulus of cancellous bone defects treated with these porous synthetic implants. The compressive mechanical properties became weaker until the second month post implantation. After the second month, these properties increased slightly and remained higher than control values. New bone formed on the outside surface and on the macropore walls of the specimens, as osteoids and osteoclasts were evident two months postoperatively. Considering these properties, these synthetic porous calcium phosphate implants could be applicable as cancellous bone substitutes.
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Association of a Synthetic Bone Graft and Bone Marrow Cells as a Composite Biomaterial
S. M. Rabiee,S. M. J. Mortazavi,F. Moztarzadeh,D. Sharifi,F. Fakhrejahani,A. Khafaf,S. A. Houshiar Ahmadi,N. Nosoudi,R. Ravarian 한국생물공학회 2009 Biotechnology and Bioprocess Engineering Vol.14 No.1
Porous calcium phosphates have osteoconductive properties. The aim of this study was to obtain synthetic calcium phosphate bone graft substitute. X-ray diffraction was employed to investigate the formation of the beta-tricalcium phosphate (β-TCP) phase. We evaluated the effects of bone marrow on the osteoconductivity and mechanical properties of synthetic bone graft (SG). SG cylinders loaded with bone marrow (SGBM) and SG alone were implanted into rabbits femoral condyle bone defects. Histological examinations revealed the resorption of the SG, trabecular bone with osteoblasts and osteoid substance around the implants, and colonization inside the porous β-TCP by newly formed bone. Histomorphometry conducted after three months revealed the osteoid surface to be higher in SGBM than SG (p < 0.05). The compressive strengths of SG and SGBM were significantly higher than the anatomic control at all time periods. The elastic modulus of SBG and SGBM became weaker after implantation. The present results indicate that β-TCP is a good matrix for bone marrow, which contributes osteoinductive properties in an orthotopic. The composite biomaterial may be useful in reconstructive bone surgery.
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