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RISS 인기검색어
- 검색키워드
- 저자 : Erwin W Gelfand (검색결과 3 건)
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Is There a Link Between Obesity and Asthma?
김상하,E. Rand Sutherland,Erwin W Gelfand 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.3
Increasing epidemiological data identify a link between obesity and asthma incidence and severity. Based on experimental data, it is possible thatshared inflammatory mechanisms play a role in determining this linkage. Although controversial, the role of adipokines may be central to this associationand the maintenance of the asthma phenotype. While leptin and adiponectin have a causal link to experimental asthma in mice, data in humansare less conclusive. Recent studies demonstrate that adipokines can regulate the survival and function of eosinophils and that these factorscan affect eosinophil trafficking from the bone marrow to the airways. In addition, efferocytosis, the clearance of dead cells, by airway macrophagesor blood monocytes appears impaired in obese asthmatics and is inversely correlated with glucocorticoid responsiveness. This review examines thepotential mechanisms linking obesity to asthma.
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Understanding asthma using animal models
신유섭,Katsuyuki Takeda,Erwin W Gelfand 대한천식알레르기학회 2009 Allergy, Asthma & Immunology Research Vol.1 No.1
Asthma is a complex syndrome with many clinical phenotypes in children and adults. Despite the rapidly increasing prevalence, clinical investigation and epidemiological studies of asthma, the successful introduction of new drugs has been limited due to the different disease phenotypes and ethical issues. Mouse models of asthma replicate many of the features of human asthma, including airway hyperreactivity, and airway inflammation. Therefore, examination of disease mechanisms in mice has been used to elucidate asthma pathology and to identify and evaluate new therapeutic agents. In this article, we discuss the various animal models of asthma with a focus on mouse strains, allergens,protocols, and outcome measurements.
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Immunomodulatory Effects of Ambroxol on Airway Hyperresponsiveness and Inflammation
Katsuyuki Takeda,Nobuaki Miyahara,Shigeki Matsubara,Christian Taube,Kenichi Kitamura,Astushi Hirano,Mitsune Tanimoto,Erwin W Gelfand 대한면역학회 2016 Immune Network Vol.16 No.3
Ambroxol is used in COPD and asthma to increase mucociliary clearance and regulate surfactant levels, perhaps through anti-oxidant and anti-inflammatory activities. To determine the role and effect of ambroxol in an experimental model of asthma, BALB/c mice were sensitized to ovalbumin (OVA) followed by 3 days of challenge. Airway hyperresponsiveness (AHR), lung cell composition and histology, and cytokine and protein carbonyl levels in bronchoalveolar lavage (BAL) fluid were determined. Ambroxol was administered either before the first OVA challenge or was begun after the last allergen challenge. Cytokine production levels from lung mononuclear cells (Lung MNCs) or alveolar macrophages (AM) were also determined. Administration of ambroxol prior to challenge suppressed AHR, airway eosinophilia, goblet cell metaplasia, and reduced inflammation in subepithelial regions. When given after challenge, AHR was suppressed but without effects on eosinophil numbers. Levels of IL-5 and IL- 13 in BAL fluid were decreased when the drug was given prior to challenge; when given after challenge, increased levels of IL-10 and IL-12 were detected. Decreased levels of protein carbonyls were detected in BAL fluid following ambroxol treatment after challenge. In vitro , ambroxol increased levels of IL-10, IFN-γ, and IL-12 from Lung MNCs and AM, whereas IL-4, IL-5, and IL-13 production was not altered. Taken together, ambroxol was effective in preventing AHR and airway inflammation through upregulation of Th1 cytokines and protection from oxidative stress in the airways.
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