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RISS 인기검색어
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- 저자 : El Maadawi, Zeinab (검색결과 2 건)
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El-Maadawy, Eman A,Talaat, Roba M,Sadek, Rawia F,El-Sherbini, Sherif M,Abdel-Bary, Naser,Abdel-Aziz, Amal A Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9
We aimed to investigate any association between hepatitis C virus (HCV) infection and non-Hodgkin's lymphoma (NHL) in the view of cytokines that control inflammation/angiogenesis and their correlation with certain CD markers. NHL patients with or without HCV infection were studied. CD5, CD30, CD3, CD20 and CD45 were immunohistochemically evaluated. Plasma levels of vascular endothelial and platelet derived growth factors (VEGF, and PDGF), tumor necrosis factor (TNF-${\alpha}$), transforming growth factor (TGF-${\beta}$), interleukin-6 (IL-6), IL-8, IL-4, IL-12 and interferon gamma (IFN-${\gamma}$) were detected by enzyme-linked immunosorbent assay (ELISA). HCV+ve NHL patients showed a significant reduction in VEGF, PDGF, IFN-${\gamma}$, CD5 and CD45 and a significant increase in IL-12 and IL-8. In conclusion, there was a significant change in cytokine secretion and expression of CD markers in HCV+ve NHL patients. Based on our results, HCV infection in NHL patients requires more in-depth investigations to explore any role in lymphoma progression.
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Robertson, Abigail,Mohamed, Tamer M.A.,El Maadawi, Zeinab,Stafford, Nicholas,Bui, Thuy,Lim, Dae-Sik,Cartwright, Elizabeth J.,Oceandy, Delvac Elsevier 2017 Stem cell research Vol.20 No.-
<▼1><P>Adult fibroblasts can be reprogrammed into induced pluripotent stem cells (iPSC) for use in various applications. However, there are challenges in iPSC generation including low reprogramming efficiency, yield, cell survival and viability. Since the Hippo signalling pathway is a key pathway involved in regulating cell proliferation and survival, we here test whether modification of the Hippo pathway will enhance the efficiency of iPSC generation and improve their survival.</P><P>The Hippo pathway was modified by genetic ablation of the mammalian sterile-20 like kinase 1 (Mst1), a major component of the pathway. Using adult skin fibroblasts isolated from Mst1 knockout mice (Mst1<SUP>−/−</SUP>) as a source of iPSC we found that genetic ablation of Mst1 leads to significantly increased reprogramming efficiency by 43.8%. Moreover, Mst1<SUP>−/−</SUP> iPSC displayed increase proliferation by 12% as well as an increase in cell viability by 20% when treated with a chemical hypoxic inducer. Mechanistically, we found higher activity of YAP, the main downstream effector of the Hippo pathway, in iPSC lacking Mst1.</P><P>In conclusion, our data suggests that Mst1 can be targeted to improve the efficiency of adult somatic cell reprogramming as well as to enhance iPSC proliferation and survival.</P></▼1><▼2><P><B>Highlights</B></P><P>•<P>Genetic deletion of Mst1 increases the efficiency of cell reprogramming.</P>•<P>iPSC lacking Mst1 displays higher proliferation rate than WT iPSC.</P>•<P>In response to chemical hypoxia Mst1<SUP>−/−</SUP> iPSC demonstrates higher survival.</P></P></▼2>
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