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RISS 인기검색어
- 검색키워드
- 저자 : Dubina A.A. (검색결과 2 건)
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Chepurnov S.A.,Chepurnova N.E.,Jin-Kyu Park,Redkozubova O.M.,Pravdukhina A.A.,Abbasova K.R.,Buzinova E.V.,Mirina A.A.,Chepurnova D.A.,Dubina A.A.,Pirogov U.A.,Curtis M.,Uva L. 고려인삼학회 2007 Journal of Ginseng Research Vol.31 No.3
Pharmacology of Korean Red ginseng gives us unique possibility to develop new class of antiepileptic drugs today and to improve one’s biological activity. The chemical structures of ginsenosides (GS) have some principal differences from well-known antiepileptic new generation drugs. The antiepileptic effect of GS was also demonstrated in all models of epilepsy in rats (young and adult), which have studied, in all models of epilepsy including status epilepticus (SE), induced by lithium - pilocarpine. In our experiments in rats new evidences on protective effects were exerted as a result of premedication by GS. Pre-treatment of several GS could induce decrease of the seizures severity and brain structural damage (by MRI), neuronal degeneration in hippocampus. Wave nature of severity of motor seizures during convulsive SE was observed during lithium-pilocarpine model of SE in rats (the first increase of seizures was 30 min after the beginning of SE and the second - 90 min after. The efficacy of treatment on SE by ginsenoside as expected was observed after no less 3 weeks by daily GS i.p. administration. It is blocked SE or significantly decrease the severity of seizures during SE. The implication of presented data is that combination of ginsenosides from Korean Red ginseng and ginseng cell culture Dan25 that could be applied for prevention of epileptical status development. However, a development of optimal ratio of different ginsenosides (Rb1 Rc, Rg, Rf,) should consummate in the new antiepileptic drug development.
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Seismic behaviour of steel beam-to-column joints with column web stiffening
D. Dubina,A. L. Ciutina 국제구조공학회 2006 Steel and Composite Structures, An International J Vol.6 No.6
The present paper summarizes the experimental research carried out at the “Politehnica” University of Timisoara, Romania, with the scope of investigating the influence of different column web stiffening solutions on the performance of beam-to-column joints of Moment Resisting Steel Frames. The response parameters, such as resistance, rigidity and ductility were examined. Five different types of panel web stiffening were compared with regard to a reference test. A quasi-linear relationship between the moment capacity and the total shear area of the web panel was observed from the experimental tests while the initial rigidity increased non-proportionally with the same area. Comparisons are presented of the experimental tests with the mathematical model developed by Krawinkler and with the model stipulated in Eurocode 3 Part 1.8. These comparisons showed a generally good agreement in the case of moment capacity, while the computed rigidities were always greater than the experimental rigidities.
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