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RISS 인기검색어
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- 저자 : Dongwei Yuan (검색결과 2 건)
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Dongwei Yuan,Yiping Luo,Yong Peng 한국자동차공학회 2019 International journal of automotive technology Vol.20 No.3
In this study, the crash-worthiness of a regular Centurion 2M barrier, which is a type of portable water-filled barrier (PWFB), is evaluated under different collision conditions. A numerical model of the regular Centurion 2M barrier, consisting of a plastic shell and water, was developed and validated. The validity of the numerical model is demonstrated by comparisons to experimental results. During the establishment of the finite element numerical model, the ALE (Arbitrary Lagrange-Euler) method was used to solve the problem of the fluid-structure interaction of the PWFB system. This model can be extended to a series of impact cases including an actual pick-up truck. Impact cases set six collision conditions according to different collision speeds and angles. The dynamic response of the collision between the pick-up truck and the PWFB process was investigated. From the analysis, we find that the greater the collision angle is, the greater the impact is on the collision result. According to the actual accident collision angle, setting the collision angle above 50° is satisfactory in most situations. In addition, a regular Centurion 2M barrier is just suitable for use on roads when the speed of vehicles is 20 km/h or less.
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Dongwei Yuan,Li Qing,Lu Xing,Lan Jianfeng,Qiu Zhidong,Wang Xuehong,Wang Junnan,Zheng Xiaojiao,Chen Sifan,Zhang Chong,Jin Junfei 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Acute liver injury is the basis of the pathogenesis of diverse liver diseases. However, the mechanism underlying liver injury is complex and not completely understood. In our study, we revealed that CERK, which phosphorylates ceramide to produce ceramide-1-phosphate (C1P), was the sphingolipid pathway-related protein that had the most significantly upregulated expression during acute liver injury. A functional study confirmed that CERK and C1P attenuate hepatic injury both in vitro and in vivo through antioxidant effects. Mechanistic studies have shown that CERK and C1P positively regulate the protein expression of NRF2, which is a crucial protein that helps maintain redox homeostasis. Furthermore, our results indicated that C1P disrupted the interaction between NRF2 and KEAP1 by competitively binding to KEAP1, which allowed for the nuclear translocation of NRF2. In addition, pull-down assays and molecular docking analyses revealed that C1P binds to the DGR domain of KEAP1, which allows it to maintain its interaction with NRF2. Importantly, these findings were verified in human primary hepatocytes and a mouse model of hepatic ischemia‒reperfusion injury. Taken together, our findings demonstrated that CERK-mediated C1P metabolism attenuates acute liver injury via the binding of C1P to the DGR domain of KEAP1 and subsequently the release and nuclear translocation of NRF2, which activates the transcription of cytoprotective and antioxidant genes. Our study suggested that the upregulation of CERK and C1P expression may serve as a potential antioxidant strategy to alleviate acute liver injury.
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