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RISS 인기검색어
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- 저자 : Davood Gholami (검색결과 2 건)
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Caffeine attenuates spermatogenic disorders in mice with induced chronic scrotal hyperthermia
Amir Raoofi,Omid Gholami,Hossein Mokhtari,Fatemeh Bagheri,Auob Rustamzadeh,Davood Nasiry,Alireza Ghaemi The Korean Society for Reproductive Medicine 2024 Clinical and Experimental Reproductive Medicine Vol.51 No.1
Objective: Chronic scrotal hyperthermia (SHT) can lead to serious disorders of the male reproductive system, with oxidative stress playing a key role in the onset of these dysfunctions. Thus, we evaluated the impact of caffeine, a potent antioxidant, on cellular and tissue disorders in mice with chronic SHT. Methods: In this experimental study, 56 adult male NMRI mice were allocated into seven equal groups. Apart from the non-treated control group, all were exposed to heat stress. Two groups, termed "preventive" and "curative," were orally administered caffeine. The preventive mice began receiving caffeine immediately prior to heat exposure, while for the curative group, a caffeine regimen was initiated 15 consecutive days following cessation of heat exposure. Each treated group was subdivided based on pairing with a positive control (Pre/ curative [Cur]+PC) or a vehicle (Pre/Cur+vehicle). Upon conclusion of the study, we assessed sperm characteristics, testosterone levels, stereological parameters, apoptosis, antioxidant and oxidant levels, and molecular markers. Results: Sperm parameters, testosterone levels, stereological parameters, biochemical factors (excluding malondialdehyde [MDA]), and c-kit gene expression were significantly elevated in the preventive and curative groups, especially the former, relative to the other groups. Conversely, expression levels of the heat shock protein 72 (HSP72) and nuclear factor kappa beta (NF-κβ) genes, MDA levels, and apoptotic cell density were markedly lower in both caffeine-treated groups relative to the other groups, with more pronounced differences observed in the preventive group. Conclusion: Overall, caffeine attenuated cellular and molecular abnormalities induced by heat stress in the testis, particularly in the mice treated under the preventive condition.
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Majid Naseri,Mohsen Reihanian,Ahmad Ostovari Moghaddam,Davood Gholami,Mohammad Alvand,Ehsan Borhani,Evgeny Trofimov 대한금속·재료학회 2024 METALS AND MATERIALS International Vol.30 No.2
This study examined mechanical properties of AA2024 alloy and its correlation between strain path and crystallographictexture. Accumulative roll bonding (ARB) and cross accumulative roll bonding (CARB) were used to severely deformAA2024 alloys. Electron backscatter diffraction (EBSD) studies demonstrated that nano/ultrafine grains were formed by thestrain routes after eight cycles. It was also found that the lamellar boundary spacing and the mean boundary spacing were~ 360 ± 10 nm and 845 ± 10 nm after eight ARB cycles. In contrast to the ARB, the CARB specimen had equiaxed microstructurescharacterized by grains with a size of 150 and 100 nm. The CARB processed specimen exhibited a mean misorientationangle of 41.83° and a fraction of high angle grain boundaries of 78%, these values were 34.57° and 67% for ARB treatedspecimen, respectively. It was observed that the evolved texture is greatly affected by the strain paths. The ARB processedspecimen revealed strong Copper {112} <111>, Dillamor {4 4 11} <11 11 8>, S {123} <634>, and Brass {011} <211>components. In contrast, the CARB processed specimen showed major texture with prominent Copper {112} <111>, Brass{011} <211>, Rotated Cube {001} <110>, S {123} <634>, and Goss {011} <100> components. In the CARB specimen, theGoss/Brass texture ratio was intensified and the mechanical properties were superior (tensile strength: 535 MPa, microhardness:182 HV, elongation: 11.9%) compared with the ARB processed specimen (tensile strength: 455 MPa, microhardness:145 HV, elongation: 9.2%). Further, the change in strain path did not significantly affect the intensity of Goss and Cubecomponents, ruling out any further recrystallization tendency.
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