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Datong Zhang,Jiong Jia,Lijuan Meng,Weiren Xu,Lida Tang,Jianwu Wang 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.6
Two series of novel 2-butyl succinate-based Hydroxamate derivatives containing isoxazole rings were synthesized, characterized and evaluated for antibacterial activity. The synthesized compounds were found to exhibit weak to moderate inhibitory activity against Staphytlococcus aureu and Klebsiellar pneumonia in vitro. All the compounds synthesized were found to be more effective against Klebsiellar pneumonia compared to Staphytlococcus aureu.
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Synthesis and Biological Evaluation of 3-(1H-indol-3-yl)pyrazole- 5-carboxylic Acid Derivatives
Datong Zhang,Guangtian Wang,Chubing Tan,Weiren Xu,Yuan Pei,Lingyan Huo 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3
A series of novel compounds bearing a 3-(1H-indol-3-yl)pyrazole-5-carboxylic acid nucleus were synthesized. Analytical and spectral data confirmed the structures of the new compounds. The structures of the regioisomers in this series were determined by 1H-NMR spectra. The title compounds were evaluated for their endothelin-1 antagonist activities. In the in vitro functional assay, compounds 23, 24, 28 and 29 exhibited significant efficacy at the concentration of 1 μg/mL, and compounds 5b, 5c, 26 and 28 were as potent as the positive control bosentan at high concentration. In the experiment to assess prevention of endothelin-1-induced sudden death in mice, compound 5b showed comparable activity to bosentan, and 30 was more potent than bosentan. The final compounds were also screened for antibacterial activity against four Gram-positive and -negative bacteria. Some of the tested compounds showed weak antibacterial activity.
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Jing Wei,Ruizhi Shu,Datong Qin,Teik C. Lim,Aiqiang Zhang,Fanming Meng 한국정밀공학회 2016 International Journal of Precision Engineering and Vol.17 No.9
Multi-source driving transmission systems, in which the gear assembly is driven by multiple induction motors, are extensively used in new energy, aerospace, marine engineering, and in other fields. The multi-source driving system faces an even-load distribution problem, i.e., torque or speed synchronization issues. In this study, the synchronization characteristics of a multi-source driving transmission system under an impact load at different load change rates are studied. An accurate electromechanical coupling dynamic model of the system considering the flexible shafts, support bearing and meshing gear pair is established by applying virtual equivalent shaft elements. By considering the time-varying meshing and the coupling effects of the dynamic electric motor and the speed, torque and stator current synchronization characteristics are investigated using this model. Computational results show that the influence of the load change rate on the speed synchronization characteristics of the system is minor, but has a significant influence on the torque and stator current synchronization characteristics. The stator current root mean square value (RMS) can be chosen as a feedback signal to monitor the synchronization characteristics of the system. The proposed research provides the theoretical basis for the formulation of the synchronization control strategy for multi-source driving transmission systems.
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Yonggang Liu,Daqi Chen,Zhenzhen Lei,Datong Qin,Yi Zhang,Rui Wu,Yong Luo 한국자동차공학회 2017 International journal of automotive technology Vol.18 No.5
This paper focuses on the dynamic modeling and control of engine starting for a Full Hybrid Electric Vehicle (FHEV) consisting of an Integrated Starter Generator (ISG) and Dual Clutch Transmissions (DCTs). The dynamic characteristics of the engine, the ISG motor and the main clutch are analyzed respectively. The dynamic models of the main components of the powertrain system are also established taking the system dynamic characteristics into consideration. The FHEV dynamic model of engine starting during electric driving mode has been investigated in detail. The coordinated control strategy of engine starting has been proposed based on the powertrain system dynamic characteristics. The simulation for the engine starting control during electric driving mode has been performed based on the Matlab/Simulink platform. The simulation results show that the proposed control strategy satisfies the requirements of response and smoothness during engine starting process. Furthermore, a bench test has been carried out to analyze the system characteristics during engine starting process. The test data is highly agreeable to the simulation data and the effectiveness of engine starting control strategy is validated by the comparison between simulation results and the test data.
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