가맹점 기회주의에 대한 일본 볼런터리 체인의 관리 전략과 조직적 과제

김창주(Changju Kim),박진용(Jin Yong Park),지성구(Seonggoo Ji),전달영(Dal Young Chun) 한국유통학회 2023 流通硏究 Vol.28 No.3

다중 이미지 센서를 활용한 인공지능 모델 기반 과채류 작물 내 객체의 3차원 위치 인식 기법에 관한 연구

천승우 ( Seung-woo Chun ),이성민 ( Seongmin Lee ),조병효 ( Byeong-hyo Cho ),이강진 ( Kangjin Lee ),홍영기 ( Youngki Hong ),김경철 ( Kyoung-chul Kim ),양창주 ( Changju Yang ) 한국농업기계학회 2023 한국농업기계학회 학술발표논문집 Vol.28 No.2

과채류 작물에 대한 시장 수요가 점점 높아지면서 이에 따른 농업환경이 변화하고 있으며, 특히 연동 온실 형태의 규모화된 농가들이 늘어나고 있다. 이에 따라 실내 환경에 적합한 형태의 농작업용 로봇 제어 기술 개발이 요구되고 있다. 실내 환경에서 접목되었던 기존의 주요 기술은 영상데이터 기반의 숙도 판정 및 질병 유무와 같은 생육상태 모니터링 등의 인식 기술을 목표로 수행되었다. 그러나 작물의 생육 전주기 동안 관리 측면에서 필요한 노동력 절감에 대한 기술적 연구는 미비한 실정이다. 기존 영상기반 인공지능 모델을 통해 작물 내에서 과실뿐만이 아니라 잎과 줄기 등 다양한 객체를 인식하기 위해 수행한 많은 연구 사례가 있으나, 온실 환경에서 재배하는 작물을 대상으로 노엽 제거 및 불필요한 가지 제거 작업과 같은 관리작업 기능을 개발하기 위해서는 사람의 팔 동작과 유사한 매니퓰레이터 제어를 위한 기초 연구가 필요하다. 본 연구에서는 과채류 작물중 시장 규모가 큰 대표적 작물 중 하나인 딸기에 대하여 농작업용 로봇을 활용하기 위한 인식 기술에 대한 것으로서, 작물의 영양생식에 부정적인 영향을 미치는 주요 객체들을 제거하기 위해 이미지 센서를 활용하여 3차원 공간상에서 위치를 찾아내고 인식하는 것을 목표로 한다. 하드웨어적으로는 상용 매니퓰레어에 산업용 컴퓨터와 PAL 3D 및 ZED2 mini 카메라를 이용하여 하드웨어 시스템을 고안하였으며, 고설 벤치 재배 방식의 실내 온실 농작업 환경에 적용 가능함을 확인하였다. 소프트웨어적으로는 부정적 요소로 간주되는 객체 검출을 위해 YOLO 기반 모델을 이용하여 알고리즘을 학습시키고 3차원 위치 정보를 통해 로봇팔 시스템이 해당 객체의 위치 정보를 이용하여 동작할 수 있음을 확인하였다.

Feasibility study on the differentiation between engineered and natural nanoparticles based on the elemental ratios

Kim, Woocheol,Yeom, Changju,Lee, Hyejin,Sung, Hwakyung,Jo, Eunhye,Eom, Ig-chun,Kim, Younghun Springer-Verlag 2017 Korean Journal of Chemical Engineering Vol.34 No.12

<P>To understand the fate and exposure of engineered nanoparticles (ENPs) to environmental media, it is important to identify ENPs in the natural occurring nanoparticles (NNPs). Although nanomaterials have unique physical properties such as uniform particle size, hierarchical nanostructure, well-defined crystalline structure, and high surface area, compared to bulk materials, these properties are not suitable references to differentiate between ENPs and NNPs. Therefore, the identification and quantification of ENPs pose a big challenge to analysis. Herein, we did a feasibility study to distinguish between ENPs and NNPs based on the elemental ratio of target elements (Ti and Zn) to background elements (Fe and Al). Morphologies, particle size, and elemental analysis for 12 NNPs, 4 ENPs, and 3 NPs contained in consumer products were conducted. NPs were extracted from raw materials via density gradient ultracentrifugation and alkaline digestion. In a logarithm plot for the elemental ratio of {Ti+Zn} to {Ti/Zn}/{Fe+Al} and ternary plot of {Ti+Zn}, Fe, and Al ions for all samples, ENPs have a distinct contrast with NNPs. Therefore, it is expected that the suggested analysis for elemental ratio could be a preliminary screening tool to differentiate between ENPs and NNPs.</P>

초친수성 유수분리필터 제조공정에 관한 전과정평가

박성묵 ( Sungmook Park ),김지은 ( Jieun Kim ),염창주 ( Changju Yeom ),이혜진 ( Heyjin Lee ),양성익 ( Sungik Yang ),엄익춘 ( Ig-chun Eom ),김필제 ( Pil-je Kim ),김영훈 ( Younghun Kim ) 한국화학공학회 2016 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.54 No.6

나노기술의 급격한 발전은 다양한 산업응용분야에 기여를 하고 있다. 그러나 나노제품의 증가와 함께, 비의도적인 환경노출이 발생되고 있다. 나노제품에 의한 잠재적인 환경영향은 전과정평가(LCA)를 통해 해석할 수 있다. LCA는 제품의 생산과 폐기에 이르는 전체 공정상의 자원소모 및 배출에 관한 체계적인 해석을 할 수 있다. 본 연구에서는, 나노-TiO₂를 이용한 초친수성 유수분리필터를 제조하는 공정에 관하여 LCA를 수행하였다. 이를 위해 무료로 공개된 TOTAL^TM을 사용하였으며, 6대 환경영향인자인 자원소모, 기후변화, 오존층영향, 산성화, 부영양화, 광화학산화물생성 등의 지표를 해석하였다. 또한 나노-TiO₂를 사용하는 것이 유수분리필터 제조공정에서 벌크-TiO₂를 사용하는 것보다 긍정적으로 환경영향인자에 기여하는 것으로 파악되었다. Rapid growth in nanotechnologies promises novel benefits through the exploitation of their unique indus-trial applications. However, as the production volume of nanomaterials increases, their unintentional exposure to the environment has been occured. Potential impacts of nanoproducts on the environment can be evaluated in the life cycle assessment (LCA). LCA is the systematic analysis of the resource usages and emissions over the life time from the pri-mary resources to the moment of disposal. In this study, we performed LCA for fabrication processes of superhydro-philic oil/water separator using nano-TiO₂. TOTAL^TM freeware was used to analyze for all fabrication processes, and 6- environmental impact factors (resource depletion, climate change, ozone depletion, acidification, eutropication, and pho-tochemical oxidation) were introduced. In addition, the use of nano-TiO₂ in the fabrication of superhydrophilic oil/water separator was actively contributed to the environmental impact factors, compared to the bulk-TiO₂.

Microstructure control of the graphite anode with a high density for Li ion batteries with high energy density

Han, Hyungkyu,Park, Hyunjung,Kil, Ki Chun,Jeon, Yeryung,Ko, Youngsan,Lee, Changju,Kim, Minjae,Cho, Chae-Woong,Kim, Kijun,Paik, Ungyu,Song, Taeseup Elsevier 2015 ELECTROCHIMICA ACTA Vol.166 No.-

<P><B>Abstract</B></P> <P>As the density of graphite anode is increasing, the pore size and volume in the graphite anode is reduced, which results in a decrease in the electrolyte permeability of electrode. The electrochemical degradation of high density graphite anode due to the low permeability is a major obstacle to its use as anode for lithium ion batteries. In this study, we report on high density graphite anode with the carbon additive added that provides micron size pore structure of the high density graphite anode, which results in an increase in the rate capability. The high density graphite anode with carbon additive exhibited 32.4% higher rate capability at 1C compared to the high density graphite anode without carbon additive. This improvement is mainly attributed to the increased micron-size pores, which enhances the kinetic associated with lithium by improved electrolyte permeation and increased interface between the electrolyte and active material.</P>

Design, synthesis and evaluation of 5-substituted 1-H-tetrazoles as potent anticonvulsant agents

Aimei LIAO,Tiantian Wang,Bangrong Cai,Yi Jin,천승훈,ChangJu Chun,Zengtao Wang 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.4

A series of 5-substituted 1-H-tetrazoles weredesigned and synthesized as potent anticonvulsant agents. Their preliminary anticonvulsant activities were evaluatedusing maximal electroshock and subcutaneouspentylenetetrazole (scPTZ) seizure tests. Neurotoxicity wasdetermined using rotarod test. The results indicated that thecompound 2j in scPTZ model exhibited the ED50 values of83.3 mg/kg, superior to the standard drug ethosuximidewith the maximum activity. In addition, compound 2kshowed the most potent activity in MES model with ED50value of 9.6 mg/kg and TD50 value of 189.5 mg/kg afterintraperitoneal injection in mice, and displayed a highprotective index (TD50/ED50) of 19.7 compared to referenceantiepileptic drugs.

A synthetic diosgenin primary amine derivative attenuates LPS-stimulated inflammation via inhibition of NF-κB and JNK MAPK signaling in microglial BV2 cells

Cai, Bangrong,Seong, Kyung-Joo,Bae, Sun-Woong,Chun, Changju,Kim, Won-Jae,Jung, Ji-Yeon Elsevier 2018 INTERNATIONAL IMMUNOPHARMACOLOGY Vol.61 No.-

<P><B>Abstract</B></P> <P>Diosgenin, a precursor of steroid hormones in plants, is known to exhibit diverse pharmacological activities including anti-inflammatory properties. In this study, (3β, 25<I>R</I>)‑spirost‑5‑en‑3‑oxyl (2‑((2((2‑aminoethyl)amino)ethyl)amino)ethyl) carbamate (DGP), a new synthetic diosgenin derivative incorporating primary amine was used to investigate its anti-inflammatory effects and underlying mechanisms of action in lipopolysaccharide (LPS)-stimulated microglial BV2 cells. Pretreatment with DGP resulted in significant inhibition of nitric oxide (NO) synthesis, and down-regulation of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-stimulated microglial BV2 cells. In addition, DGP decreased the production of reactive oxygen species (ROS) and pro-inflammatory cytokines such as interleukin (IL)-6, IL-1β, and tumor necrosis factor alpha (TNF-α). The inhibitory effects of DGP on these inflammatory mediators in LPS-stimulated microglial BV2 cells were regulated by NF-κB signaling through blocking p65 nuclear translocation and NF-κB p65/DNA binding activity. DGP also blocked the phosphorylation of c-Jun amino-terminal kinase (JNK), but not p38 kinase or extracellular signal-regulated kinases (ERK). The NF-κB inhibitor JSH-23 and JNK-specific inhibitor SP600125 significantly decreased NO production and IL-6 release in LPS-stimulated BV2 cells, respectively. The overall results demonstrate that DGP has anti-inflammatory effects on LPS-stimulated BV2 cells via inhibition of NF-κB and JNK activation, suggesting that DGP is a potential prophylactic agent in various neurodegenerative disorders.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new synthetic diosgenin derivative incorporating primary amine (DGP) was prepared. </LI> <LI> DGP suppresses LPS-stimulated inflammatory responses in microglial BV2 cells. </LI> <LI> DGP exerts anti-inflammatory effect via inhibition of NF-κB and JNK MAPK signaling. </LI> <LI> DGP has potential to prevent various neurodegenerative disorders as a therapeutic agent. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Design, synthesis of methotrexate-diosgenin conjugates and biological evaluation of their effect on methotrexate transport-resistant cells

( Bangrong Cai ),( Aimei Liao ),( Kyung-ku Lee ),( Jae-sam Ban ),( Hyun-sam Yang ),( Young Jun Im ),( Changju Chun ) 전남대학교 약품개발연구소 2016 약품개발연구지 Vol.25 No.-

A series of methotrexate-diosgenin conjugates was designed and synthesized to enhance the passive internalization of methotrexate (MTX) in to transport-resistant cells. The inhibitory effects of these con-jugates on dihydrofolate reductase (DHFR), and their anti-proliferation behaviors against a transport-resistant breast cancer cell line, MDA-MB-231, were investigated. All of the synthesized conjugates retained an ability to inhibit DHFR after the diosgenin substitution. The MTX conjugates were much more potent against methotrexate-resistant MDA-MB-231 cells than MTX. Conjugate 18, containing a disulfide bond, exhibited the most potent anti-proliferative and DHFR inhibitory effects (IC₅₀=4.1 μM and 17.21 nM, respectively). Anti-proliferative activity was higher in the conjugate with a longer space linker (conjugate 21) than those with shorter linkers (conjugates 19 and 20). These results suggest that dios-genin conjugation of MTX may be an effective way to overcome its transport resistance in cancer cells. ⓒ 2016 Elsevier Inc. All rights reserved.