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Comparative genomics of clinical and environmental Vibrio mimicus
Hasan, N. A.,Grim, C. J.,Haley, B. J.,Chun, J.,Alam, M.,Taviani, E.,Hoq, M.,Munk, A. C.,Saunders, E.,Brettin, T. S.,Bruce, D. C.,Challacombe, J. F.,Detter, J. C.,Han, C. S.,Xie, G.,Nair, G. B.,Huq, A. Proceedings of the National Academy of Sciences 2010 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.107 No.49
Chun, J.,Grim, C. J.,Hasan, N. A.,Lee, J. H.,Choi, S. Y.,Haley, B. J.,Taviani, E.,Jeon, Y.-S.,Kim, D. W.,Lee, J.-H.,Brettin, T. S.,Bruce, D. C.,Challacombe, J. F.,Detter, J. C.,Han, C. S.,Munk, A. C. Proceedings of the National Academy of Sciences 2009 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.106 No.36
<P>Vibrio cholerae, the causative agent of cholera, is a bacterium autochthonous to the aquatic environment, and a serious public health threat. V. cholerae serogroup O1 is responsible for the previous two cholera pandemics, in which classical and El Tor biotypes were dominant in the sixth and the current seventh pandemics, respectively. Cholera researchers continually face newly emerging and reemerging pathogenic clones carrying diverse combinations of phenotypic and genotypic properties, which significantly hampered control of the disease. To elucidate evolutionary mechanisms governing genetic diversity of pandemic V. cholerae, we compared the genome sequences of 23 V. cholerae strains isolated from a variety of sources over the past 98 years. The genome-based phylogeny revealed 12 distinct V. cholerae lineages, of which one comprises both O1 classical and El Tor biotypes. All seventh pandemic clones share nearly identical gene content. Using analogy to influenza virology, we define the transition from sixth to seventh pandemic strains as a 'shift' between pathogenic clones belonging to the same O1 serogroup, but from significantly different phyletic lineages. In contrast, transition among clones during the present pandemic period is characterized as a 'drift' between clones, differentiated mainly by varying composition of laterally transferred genomic islands, resulting in emergence of variants, exemplified by V. cholerae O139 and V. cholerae O1 El Tor hybrid clones. Based on the comparative genomics it is concluded that V. cholerae undergoes extensive genetic recombination via lateral gene transfer, and, therefore, genome assortment, not serogroup, should be used to define pathogenic V. cholerae clones.</P>