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      • <i>Salmonella enterica</i> Serovar Typhimurium Interacts with CD209 Receptors To Promote Host Dissemination and Infection

        Ye, Chenglin,Li, Qiao,Li, Xinyi,Park, Chae Gyu,He, Yingxia,Zhang, Yingmiao,Wu, Bicong,Xue, Ying,Yang, Kun,Lv, Yin,Ying, Xiao-Ling,Ding, Hong-Hui,Cai, Huahua,Alkraiem, Ayman Ahmad,Njiri, Olivia,Tembo, American Society for Microbiology 2019 Infection and immunity Vol.87 No.8

        <P><I>Salmonella enterica</I> serovar Typhimurium, a Gram-negative bacterium, can cause infectious diseases ranging from gastroenteritis to systemic dissemination and infection. However, the molecular mechanisms underlying this bacterial dissemination have yet to be elucidated. A study indicated that using the lipopolysaccharide (LPS) core as a ligand, <I>S</I>.</P><P><I>Salmonella enterica</I> serovar Typhimurium, a Gram-negative bacterium, can cause infectious diseases ranging from gastroenteritis to systemic dissemination and infection. However, the molecular mechanisms underlying this bacterial dissemination have yet to be elucidated. A study indicated that using the lipopolysaccharide (LPS) core as a ligand, <I>S</I>. Typhimurium was able to bind human dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (hCD209a), an HIV receptor that promotes viral dissemination by hijacking antigen-presenting cells (APCs). In this study, we showed that <I>S</I>. Typhimurium interacted with CD209s, leading to the invasion of APCs and potentially the dissemination to regional lymph nodes, spleen, and liver in mice. Shielding of the exposed LPS core through the expression of O-antigen reduces dissemination and infection. Thus, we propose that similar to HIV, <I>S</I>. Typhimurium may also utilize APCs via interactions with CD209s as a way to disseminate to the lymph nodes, spleen, and liver to initiate host infection.</P>

      • Method and Analysis of Medium and Long Term Satellite Orbit Prediction Based on Satellite Broadcast Ephemeris Parameters

        Zhu Yunhang,Xi Chao,Cai Chenglin 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.2

        Given the lag of IGS precise ephemeris and complexity of dynamic models, in order to solve the problem of long-term satellite orbit prediction in autonomous orbit determination, a new medium and long term orbit prediction method that based on satellite broadcast ephemeris parameters has been put forward. This method is that forecasting the orbit parameters firstly according to broadcast ephemeris history data, and then calculating satellite position according to the forecast ephemeris parameters. In order to verify the feasibility of this method, using 40 days of broadcast ephemeris data, adopting ARMA model combined with sliding window model to predict broadcast ephemeris orbit parameters value in 25 days. Analyzed the parameters prediction error and the influence of parameters prediction error to satellite orbit accuracy, 25 days of orbit prediction error can be controlled in 150 meters. The results show that the predictability of orbit parameters has certain application value for satellite orbit prediction, the medium and long term orbit prediction that based on the satellite broadcast ephemeris parameters is a new and feasible method of orbit prediction.

      • An Algorithm for Inter-Satellite Autonomous Time Synchronization and Ranging in the Beidou Navigation Satellite System

        Pan Yi,Liu Huafu,Zhang Zhuxian,Huang Feijiang,Cai Chenglin,Feng Lu 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.7

        Aiming at the requirement of the autonomous time synchronization in BeiDou Navigation Satellite System (BDS), an algorithm for inter-satellite autonomous time synchronization and ranging is proposed. Based on the establishment of the inter-satellite link length model of the BDS, a series of simulation has been carried out through the use of STK (Satellite Tool Kit), which includes the simulation of the length changing rules, the length variation scale and its variation ratio. Based on these simulations, an analysis of the impact of satellite motion on the inter-satellite two-way time synchronization and range has been presented. In this algorithm, the inter-satellite clock-offset and range with minimal error are acquired by utilizing the combination of clock-offset fitting polynomial and range fitting polynomial based on the least square fitting of data generated from the inter-satellite two-way time synchronization. Empirical evaluation of the BDS simulation shows that our time synchronization error is 2ns, and ranging error is 2m under the condition of acceptable simulation error. With the application of the algorithm to the inter-satellite autonomous time synchronization and ranging, the high-accuracy measurement of inter-satellite clock-offset and range of BDS can be reached.

      • A GPS/GSM Based Vehicle Monitoring and Anti-Theft System

        Pan Yi,Liu Huafu,Feng Lu,Zhang Zhuxian,Huang Feijiang,Cai Chenglin 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.7

        Aiming at the requirement of remote monitoring and anti-theft system, a GPS/GSM based mobile phone remote vehicle monitoring and anti-theft system is developed. The system design contains two parts: hardware part and software part. On the hardware design, the STC89C52 chip is chosen as the main control chip, the u-blox NEO-6M chip is used as the vehicle position information module, and the GTIM900-B chip is adopted as the short message sending module. On the software design of the system, a single-chip microcomputer program, an analog serial port program, a GPS information processing program and a GSM short message sending program are implemented. In addition, the system has developed algorithms, including map displaying algorithm, speech alarming algorithm and short message trapping algorithm. When an abnormal moving distance exceeds 100 meters, the current vehicle position will be identified and displayed on the APP map of the mobile phone in real time for the vehicle owner, and the system will warning the owner that the vehicle has moved by speech alarming. The system is the low-cost, and can be applied extensively on the remote monitoring of personal vehicle and the remote trapping and location of the outside moving subject.

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