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6 시그마 CTQ 분석을 통한 EV 급속충전기 소음측정량 오차 축소
송택호(Song taek ho),이한별(Lee han buel),김철우(Kim Cheol Woo) 한국조명·전기설비학회 2011 한국조명·전기설비학회 학술대회논문집 Vol.2011 No.5월
EV(Electric Vehicle) Quick Charger converts AC Power to DC Power, and during this energy conversion switching loss turns out to be heating phenomena and cooling fan operation begins. With this operation of cooling fan, noise is generated. Korea Electric Power Corporation regulates noise levels by 65 ㏈ so that it could avoid any suit from people living nearby the equipment. In this paper, critical factors to quality have been found through 6 sigma methodology, using 3 factors 2 level matrix experimental methodology. The best condition for measurement of noise in EV Quick charger operation was turn out to be such a conditon that suppression of test ground reflection, weather condition, angle between microphone direction and noise propagation, measurement horizontal & altitude distance should be considered so that we can reduce more than 30 % of noise level reduction.
Kim, S.,Hoffman, Gregory R.,Poulogiannis, G.,Buel, Gwen R.,Jang, Y.,Lee, K.,Kim, B.Y.,Erikson, Raymond L.,Cantley, Lewis C.,Choo, Andrew Y.,Blenis, J. Cell Press 2013 Molecular cell Vol.49 No.1
The metabolism of glucose and glutamine, primary carbon sources utilized by mitochondria to generate energy and macromolecules for cell growth, is directly regulated by mTORC1. We show that glucose and glutamine, by supplying carbons to the TCA cycle to produce ATP, positively feed back to mTORC1 through an AMPK-, TSC½-, and Rag-independent mechanism by regulating mTORC1 assembly and its lysosomal localization. We discovered that the ATP-dependent TTT-RUVBL½ complex was disassembled and repressed by energy depletion, resulting in its decreased interaction with mTOR. The TTT-RUVBL complex was necessary for the interaction between mTORC1 and Rag and formation of mTORC1 obligate dimers. In cancer tissues, TTT-RUVBL complex mRNAs were elevated and positively correlated with transcripts encoding proteins of anabolic metabolism and mitochondrial function-all mTORC1-regulated processes. Thus, the TTT-RUVBL½ complex responds to the cell's metabolic state, directly regulating the functional assembly of mTORC1 and indirectly controlling the nutrient signal from Rags to mTORC1.
Nutrient Regulation of the mTOR Complex 1 Signaling Pathway
김상균,John Blenis,Gwen R. Buel 한국분자세포생물학회 2013 Molecules and cells Vol.35 No.6
The mammalian target of rapamycin (mTOR) is an evolu-tionally conserved kinase which exists in two distinct structural and functional complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). Of the two complexes, mTORC1 couples nutrient abundance to cell growth and proliferation by sensing and integrating a variety of inputs arising from amino acids, cellular stresses, energy status, and growth factors. Defects in mTORC1 regulation are implicated in the development of many metabolic diseases, including cancer and diabetes. Over the past decade, significant advances have been made in deciphering the complexity of the signaling processes contributing to mTORC1 regulation and function, but the mechanistic details are still not fully understood. In particular, how amino acid availability is sensed by cells and signals to mTORC1 remains unclear. In this review, we discuss the current understanding of nutrient-dependent control of mTORC1 signaling and will focus on the key components involved in amino acid signaling to mTORC1.