http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Brodzik, R (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Production of antibodies in plants: approaches and perspectives.
Ko, K,Brodzik, R,Steplewski, Z Springer-Verlag 2009 Current topics in microbiology and immunology Vol.332 No.-
<P>Advances in molecular biology, immunology, and plant biotechnology have changed the paradigm of plant as a food source to so-called plant bioreactor to produce valuable recombinant proteins. These include therapeutic or diagnostic monoclonal antibodies, vaccines, and other biopharmaceutical proteins. The plant as a bioreactor for the production of therapeutic proteins has several advantages, which include the lack of animal pathogenic contaminants, low cost of production, and ease of agricultural scale-up compared to other currently available systems. Thus, plants are considered to be a potential alternative to compete with other systems such as bacteria, yeast, or insect and mammalian cell culture. Plant production systems, particularly therapeutic antibodies, are very attractive to pharmaceutical companies to produce the antibodies in demand. Currently, we have successfully developed a plant system for production of anti-rabies monoclonal antibody and anti-colorectal cancer monoclonal antibody. The effective plant production system for recombinant antibodies requires the appropriate plant expression machinery with optimal combination of transgene expression regulatory elements, control of posttranslational protein processing, and efficient purification methods for product recovery. However, there are several limitations that have to be resolved to establish the efficient plant system for antibody production. Here, we discuss the approaches and perspectives in plant systems to produce monoclonal antibody.</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
