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Minjae Kwon,Jeong Hoon Park,Beom-SuJang,정현 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.8
“Cat’s eye”-shaped [57Co]CoO@SiO2 core-shell nanostructure was prepared by the reverse microemulsion method combined with radioisotope technique to investigate a potential imaging agent for a single photon emission computed tomography (SPECT) in nuclear medicine. The core cobalt oxide nanorods were obtained by thermal decomposition of Co-(oleate)2 precursor from radio isotope Co-57 containing cobalt chloride and sodium oleate. The SiO2 coating on the surface of the core cobalt oxide nanorods was produced by hydrolysis and a condensation reaction of tetraethylorthosilicate (TEOS) in the water phase of the reverse microemulsion system. In vivo test, micro SPECT image was acquired with nude mice after 30 min of intravenous injection of [57Co]CoO@SiO2 core-shell nanostructure.
Kang-Hyuk Choi,Ul-Jae Park,JONG-BUM KIM,Beom-SuJang 대한방사성의약품학회 2019 Journal of radiopharmaceuticals and molecular prob Vol.5 No.1
The activities per volume of 188Re and 99mTc from their generators are dependent on the specific activity oftheir mother nuclides 188W and 99Mo respectively. After a particular lapse of time, the eluted RI activity isexponentially reduced and thus cannot satisfy the needs of clinical application. The purpose of this study is todevelop a 188Re and 99mTc concentration device with a compact size that can extend the period of use as wellas conveniently concentrate the RI. We designed the concentration module by including two-different checkvalves that do not required any manual on-off operations. In these concentration process, cation exchangeresin embedded with Ag and anion exchange resins were used. After completing the concentrating step,the recovering yield was identified to be more than 93% for 188Re generators and 88% for 99mTc generators. Moreover, all these procedures were done within 5 min.