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RISS 인기검색어
- 검색키워드
- 저자 : Ben-Nissan, B. (검색결과 3 건)
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Bioinspired materials for regenerative medicine: going beyond the human archetypes
Green, D. W.,Ben-Nissan, B.,Yoon, Kyung-Sik,Milthorpe, B.,Jung, H.-S. The Royal Society of Chemistry 2016 Journal of materials chemistry. B, Materials for b Vol.4 No.14
<P>The evolution of life has given rise to innumerable biomaterials with high levels of functional sophistication and performance among many thousands of different environments. The inexhaustible range of strategies and the intrinsic good design they possess can be readily included in the design of biomedical devices and materials, such as wound healing bandages and antibacterial surface coating implants. We highlight topical examples where various ingenious design strategies from biological models, originating more broadly from zoology and botany, have been appropriated into novel synthetic materials and structures for regenerative and material-based tissue engineering. Bioinspired materials engineering informed and enriched by the vast array of adaptations and strategies in nature, beyond human biology, will be instrumental in the future evolution of new more clinically acceptable pan-functional materials and structures with a broad range of uses in the regenerative sciences.</P>
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Natural and Synthetic Coral Biomineralization for Human Bone Revitalization
Green, David W.,Ben-Nissan, Besim,Yoon, Kyung Sik,Milthorpe, Bruce,Jung, Han-Sung Elsevier 2017 Trends in biotechnology Vol.35 No.1
<P>Coral skeletons can regenerate replacement human bone in nonload-bearing excavated skeletal locations. A combination of multiscale, interconnected pores and channels and highly bioactive surface chemistry has established corals as an important alternative to using healthy host bone replacements. Here, we highlight how coral skeletal systems are being remolded into new calcified structures or synthetic corals by biomimetic processes, as places for the organized permeation of bone tissue cells and blood vessels. Progressive technologies in coral aquaculture and self-organization inorganic chemistry are helping to modify natural corals and create synthetic coral architectures able to accelerate bone regeneration with proper host integration at more skeletal locations, adapted to recent surgical techniques and used to treat intrinsic skeletal deformities and metabolic conditions.</P> <P><B>Trends</B></P> <P>Coral organisms secrete a range of zoological-wide bioactive proteins and molecules that permeate the skeleton. Some of these are potentially useful in biomedicine, including limited applications in reconstructive skeletal surgery.</P> <P>Coral polyp organisms can be nurtured within bioreactors on small microchips. These chips can promote the excretion of various human-active proteins and other biomolecules.</P> <P>Certain coralline structures have shown effectiveness as safe and effective drug carriers that deliver their payload on site with graduated dosages; others can be used as bioreactor environments for stem cell expansion and rapid specialization into bone tissues in laboratory cultivation and in patients.</P> <P>Techniques in biomimetic self-organization chemistry are providing the opportunity to grow synthetic coral-like structures and morphologies bearing component structures on many scales.</P>
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Thanida Charoensuk,Chitnarong Sirisathitkul,Upsorn Boonyang,Innocent J. Macha,Yaowarat Sirisathitkul,Besim Ben-Nissan 한양대학교 세라믹연구소 2016 Journal of Ceramic Processing Research Vol.17 No.7
The three-phase of SiO2-CaO-P2O5 bioactive glass was successfully fabricated with three dimensionally ordered macroporous(3DOM) structure by incorporating a colloidal crystal template in the sol-gel synthesis. Whereas the composition andpurification of all four- and five-phase bioactive glasses were obtained after the inclusion of sodium nitrate and ferric nitratenonahydrate, the phase additions resulted in the deformation of the scaffolds and the curved walls were thinner with largervariations in size. Such difference was due to the gel-coating on spherical crystals instead of the filling in the interstitial holesof the template. Moreover, the bioactive glass microspheres were formed on the surface of the scaffolds due to the strongprecursor-template interactions. Nevertheless, the five-phase bioactive glasses exhibited the thermal stability up to 1000 oCwith slight mass loss and heat transfer.
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