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- 저자 : Baglietto, Laura (검색결과 4 건)
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Ben Magolan,Emilio Baglietto,Cameron Brown,Igor A. Bolotnov,Gretar Tryggvason,Jiacai Lu 한국원자력학회 2017 Nuclear Engineering and Technology Vol.49 No.6
Direct Numerical Simulation (DNS) serves as an irreplaceable tool to probe the complexities of multiphase flow and identify turbulent mechanisms that elude conventional experimental measurement techniques. The insights unlocked via its careful analysis can be used to guide the formulation and development of turbulence models used in multiphase computational fluid dynamics simulations of nuclear reactor applications. Here, we perform statistical analyses of DNS bubbly flow data generated by Bolotnov (Reτ = 400) and LueTryggvason (Reτ = 150), examining single-point statistics of mean and turbulent liquid properties, turbulent kinetic energy budgets, and two-point correlations in space and time. Deformability of the bubble interface is shown to have a dramatic impact on the liquid turbulent stresses and energy budgets. A reduction in temporal and spatial correlations for the streamwise turbulent stress (uu) is also observed at wall-normal distances of y+ = 15, y/δ = 0.5, and y/δ = 1.0. These observations motivate the need for adaptation of length and time scales for bubble-induced turbulence models and serve as guidelines for future analyses of DNS bubbly flow data.
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Toward an Accurate Approach for the Prediction of the Flow in a T-junction: URANS
E. MERZARI,A. KHAKIM,H. NINOKATA,E. BAGLIETTO 한국원자력학회 2009 Nuclear Engineering and Technology Vol.41 No.9
In this study, a CFD methodology is employed to address the problem of the prediction of the flow in a T-junction. An Unsteady Reynolds Averaged Navier-Stokes (URANS) approach has been selected for its low computational cost. Moreover, Unsteady Reynolds Navier-Stokes methodologies do not need complex boundary formulations for the inlet and the outlet such as those required when using Large Eddy Simulation (LES) or Direct Numerical Simulation (DNS). The results are compared with experimental data and an LES calculation. In the past, URANS has been tried on T-junctions with mixed results. The biggest limit observed was the underestimation of the oscillatory behavior of the temperature. In the present work, we propose a comprehensive approach able to correctly reproduce the root mean square (RMS) of the temperature directly downstream of the T-junction for cases where buoyancy is not present.
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TOWARD AN ACCURATE APPROACH FOR THE PREDICTION OF THE FLOW IN A T-JUNCTION: URANS
Merzari, E.,Khakim, A.,Ninokata, H.,Baglietto, E. Korean Nuclear Society 2009 Nuclear Engineering and Technology Vol.41 No.9
In this study, a CFD methodology is employed to address the problem of the prediction of the flow in a T-junction. An Unsteady Reynolds Averaged Navier-Stokes (URANS) approach has been selected for its low computational cost. Moreover, Unsteady Reynolds Navier-Stokes methodologies do not need complex boundary formulations for the inlet and the outlet such as those required when using Large Eddy Simulation (LES) or Direct Numerical Simulation (DNS). The results are compared with experimental data and an LES calculation. In the past, URANS has been tried on T-junctions with mixed results. The biggest limit observed was the underestimation of the oscillatory behavior of the temperature. In the present work, we propose a comprehensive approach able to correctly reproduce the root mean square (RMS) of the temperature directly downstream of the T-junction for cases where buoyancy is not present.
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Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium.
Gaudet, Mia M,Milne, Roger L,Cox, Angela,Camp, Nicola J,Goode, Ellen L,Humphreys, Manjeet K,Dunning, Alison M,Morrison, Jonathan,Giles, Graham G,Severi, Gianluca,Baglietto, Laura,English, Dallas R,Cou American Association for Cancer Research 2009 Cancer Epidemiology, Biomarkers & Prevention Vol.18 No.5
<P>Previous studies have suggested that minor alleles for ERCC4 rs744154, TNF rs361525, CASP10 rs13010627, PGR rs1042838, and BID rs8190315 may influence breast cancer risk, but the evidence is inconclusive due to their small sample size. These polymorphisms were genotyped in more than 30,000 breast cancer cases and 30,000 controls, primarily of European descent, from 30 studies in the Breast Cancer Association Consortium. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) as a measure of association. We found that the minor alleles for these polymorphisms were not related to invasive breast cancer risk overall in women of European descent: ECCR4 per-allele OR (95% CI) = 0.99 (0.97-1.02), minor allele frequency = 27.5%; TNF 1.00 (0.95-1.06), 5.0%; CASP10 1.02 (0.98-1.07), 6.5%; PGR 1.02 (0.99-1.06), 15.3%; and BID 0.98 (0.86-1.12), 1.7%. However, we observed significant between-study heterogeneity for associations with risk for single-nucleotide polymorphisms (SNP) in CASP10, PGR, and BID. Estimates were imprecise for women of Asian and African descent due to small numbers and lower minor allele frequencies (with the exception of BID SNP). The ORs for each copy of the minor allele were not significantly different by estrogen or progesterone receptor status, nor were any significant interactions found between the polymorphisms and age or family history of breast cancer. In conclusion, our data provide persuasive evidence against an overall association between invasive breast cancer risk and ERCC4 rs744154, TNF rs361525, CASP10 rs13010627, PGR rs1042838, and BID rs8190315 genotypes among women of European descent.</P>
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