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RISS 인기검색어
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- 저자 : Aying Zhang (검색결과 2 건)
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Aying Zhang,Qi Yang;Heping Zhang;Chen Liu;Liping Huang;Lili Zhao 한국식물학회 2018 Journal of Plant Biology Vol.61 No.6
The NAC proteins are plant-specific transcriptionfactors and widely distributed in plants. The wide functionsof NAC transcription factors were studied, but the roles ofNAC in pollen development are largely unclear. Here, wefound that ZmNAC84 played a vital role in maize pollendevelopment. ZmRbohH showed high expression in pollen. ZmNAC84 inhibited the ZmRbohH expression by directlybinding to its promoter in pollen. Moreover, phosphorylationof ZmNAC84 at Ser113 played an important role in thisprocess. These results suggest that ZmNAC84 plays anegative role in pollen development possibly via repressingthe ZmRbohH expression.
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Nano-Drone for T2 Turbo Spin Echo (TSE) MRI In Gastric Cancer Mice Model
Gippeum Park,Muzaffar Annaev,Sejin Park,Soe Lwin Aye,Zafar Aminov,Ken Karl Zhang,Hwunjae Lee 한국자기학회 2024 Journal of Magnetics Vol.29 No.1
In the ever-evolving field of Magnetic Resonance Imaging (MRI), an array of innovative techniques are emerging that incorporate the use of contrast agents, with a particular focus on their application in the diagnosis of cancer. These cutting-edge strategies commonly involve the integration of MRI with a biocompatible targeting entity and Magnetic Nanoparticles (MNPs), a combination that has demonstrated significant efficacy in the detection of cancerous cells. Among these pioneering approaches, one strategy that shows remarkable promise involves the coupling of MRI with a Nano-drone (NH2-PEGylated Hyaluronic Acid-Manganese ferrite). This novel nano-drone is fabricated using a thermal decomposition method, a process known for its precision and reliability. The resultant Nano-drone exhibits sensitivity to T2 weighted or T2 Turbo Spin Echo (TSE) MRI, paving the way for new diagnostic possibilities in the realm of cancer detection. To validate the efficacy of this innovative approach, we designed an experiment that involved the injection of a specific Gastric Cancer cell line, known as MKN-45, into murine gastric tissue. This strategic application allowed us to closely monitor the interaction of the Nano-drone with the cancer cells. In the subsequent stages of the experiment, we utilized T2 TSE magnetic resonance sequences to evaluate the imaging impact of the Nano-drone. This assessment was crucial in determining the targeting proficiency of the Nano-drone, and how effectively it could pinpoint the cancer cells within the gastric tissue. Our findings from this comprehensive study suggest the potential of the Nano-drone as a groundbreaking probe for the visualization of Gastric Cancer. Furthermore, they underscore the significance of TSE validation in unveiling new diagnostic possibilities. The results of our study offer a beacon of hope in the fight against cancer, demonstrating the potential of the Nano-drone to open new avenues in cancer diagnosis and treatment.
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