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RISS 인기검색어
- 검색키워드
- 저자 : Ayed A. Dera (검색결과 2 건)
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Ayed A. Dera,Prasanna Rajagopalan,Majed Al Fayi,Irfan Ahmed,Harish C. Chandramoorthy 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.6
In this study, we report the combination ofindirubin-3-monoxime (I3M) and thymoquinone (Tq) tohave excellent therapeutic effi cacy in models of Lung cancer(LC). Preliminary screening was done with A549 cells. Cellcycle, apoptosis and NFκB phosphorylation were determinedby fl ow cytometry, while apoptotic proteins, Akt and mTORwere assessed by western blotting. Mouse xenograft modelwas used to assess the therapeutic effi cacy in-vivo . Synergisticreduction in cell viability was observed with I3M + Tqcombinations, which were non-toxic to normal HFL-1 cells. Cell cycle analysis indicated G 1 phase reduction with subsequentaccumulation of sub G 0 contents. Annexin V assayrevealed higher apoptotic cells with combinations comparedto individual treatments with a decrease in Bcl-2/Bax ratio. The combinations exhibited anti-metastasis activity in cellmigration in the scratch, scatter and tumour cell migration assays and eff ectively reduced the tumour growth in mouse xenograft model. Expression levels of p-AKT, p-mTOR,Caspase-3, p-53 and NFκB were signifi cantly reduced inthe combination treated mice compared to individual treatments. Results of current study demonstrate clear effi cacy ofI3M + Tq combinations in LC models mediated by suppressingAkt/mTOR/NFκB signalling. Further research is recommendedto transform these fi ndings into novel therapeuticcombinations against LC.
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Effects of Photobiomodulation Therapy on Glycemic and Lipid Profiles In Vitro
Abdulrahim R. Hakami,Sultan Alasmari,Mohammed Makkawi,Adel Abo Mansour,Irfan Ahmad,Mesfer Al Shahrani,Ali Alkhathami,Ayed A. Dera,Jaya Shanker Tedla,Saleh Almane,Abdulaziz Abudahish,Jawaher AbuHadhyah 대한의학레이저학회 2020 MEDICAL LASERS Vol.9 No.2
Background and Objectives This study aimed at examining the effects of photobiomodulation therapy (PBMT) on glucose, cholesterol, triglycerides, and low- and high-density lipoprotein (LDL and HDL, respectively) levels in vitro. Materials and Methods A total of 38 serum samples collected in plain (n=10) and heparinized tubes (n=28) were subjected to PBMT at 60 Joules (J)/cm2 for 2 min at 810 nm. The glucose and lipid profiles, cholesterol, triglycerides, LDL, and HDL of each sample was measured before and after PBMT. Results A statistically significant increase in glucose levels was observed in the PBMT-sera in 8 out of 10 samples in plain tubes. However, only two samples that were prepared in heparinized tubes showed an increase in glucose levels. The remaining heparinized samples that were exposed to PBMT presented lower glucose values. The treated sera exhibited a fluctuation in the lipid profiles after PBMT. However, high cholesterol levels were evident following PBMT. Similar trends with HDL and LDL in heparinized tubes were evident. Conclusion Together, the findings suggest that photobiomodulation exhibits an effect on glycemic and lipid profiles in vitro. Hence, the use of low-level laser therapy could have therapeutic potential. However, the differences between individual responses appear to indicate that the impact of PBMT may not always be beneficial.
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