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- 저자 : Ather Khan (검색결과 3 건)
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Endoplasmic Reticulum Stress: Implications for Neuropsychiatric Disorders
Ather Muneer,Rana Mozammil Shamsher Khan 전남대학교 의과학연구소 2019 전남의대학술지 Vol.55 No.1
The Endoplasmic reticulum (ER), an indispensable sub-cellular component of the eukaryotic cell carries out essential functions, is critical to the survival of the organism. The chaperone proteins and the folding enzymes which are multi-domain ER effectors carry out 3-dimensional conformation of nascent polypeptides and check misfolded protein aggregation, easing the exit of functional proteins from the ER. Diverse conditions, for instance redox imbalance, alterations in ionic calcium levels, and inflammatory signaling can perturb the functioning of the ER, leading to a build-up of unfolded or misfolded proteins in the lumen. This results in ER stress, and aiming to reinstate protein homeostasis, a well conserved reaction called the unfolded protein response (UPR) is elicited. Equally, in protracted cellular stress or inadequate compensatory reaction, UPR pathway leads to cell loss. Dysfunctional ER mechanisms are responsible for neuronal degeneration in numerous human diseases, for instance Alzheimer’s, Parkinson’s and Huntington’s diseases. In addition, mounting proof indicates that ER stress is incriminated in psychiatric diseases like major depressive disorder, bipolar disorder, and schizophrenia. Accumulating evidence suggests that pharmacological agents regulating the working of ER may have a role in diminishing advancing neuronal dysfunction in neuropsychiatric disorders. Here, new findings are examined which link the foremost mechanisms connecting ER stress and cell homeostasis. Furthermore, a supposed new pathogenic model of major neuropsychiatry disorders is provided, with ER stress proposed as the pivotal step in disease development.
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Akbar, Ali,Bhatti, Abu Bakar Hafeez,Niazi, Samiullah Khan,Syed, Amir Ali,Khattak, Shahid,Raza, Syed Hassan,Kazmi, Ather Saeed Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.1
Background: Limited data are available regarding the impact of time duration between chemoradiation (CRT) and surgery on pathological complete response (PCR). A PCR translates into better overall and disease free survival. The objective of this study was to determine effect of time duration on outcome after preoperative CRT in rectal cancer. Materials and Methods: A retrospective review of patients undergoing operations for rectal adenocarcinoma between January 2005 and December 2010 was performed. Patients were divided in two groups: Group 1 underwent surgery in ${\leq}8weeks$ post neoadjuvant CRT and Group 2 after 8 weeks. Patient characteristics, surgical procedure, histopathological details and number of loco-regional and distant failures were compared. Expected 5 year overall survival and disease free survival was calculated using Kaplan Meier curves and significance was determined using the log rank test. Results: There were 66 patients in group 1 and 93 in group 2. No significant difference in PCR was observed between the two. However, estimated 5 year DFS was significantly higher in Group 1 (66.7%) as compared to Group 2 (53.8%) (P=0.04). Estimated overall 5 year overall survival was not significantly different at 68.2% versus 54.3% (P= 0.09). Conclusions: Delaying surgery more than 8 weeks after preoperative CRT does not impact for PCR in rectal cancer.
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Hashmi S.S. Ahmed,G. Khushbu,M. Anbarasu,Ather Khan 국제구조공학회 2024 Structural Engineering and Mechanics, An Int'l Jou Vol.90 No.2
This article presents the behaviour and design of cold-formed steel (CFS) web-stiffened lipped channel beams that primarily fail owing to the buckling interaction of distortional and global buckling modes. The incorporation of an intermediate stiffener in the web of the lipped channel improved the buckling performance leads to distortional buckling at intermediate length beams. The prediction of the strength of members that fail in individual buckling modes can be easily determined using the current DSM equations. However, it is difficult to estimate the strength of members undergoing buckling interactions. Special attention is required to predict the strength of the members undergoing strong buckling interactions. In the present study, the geometric dimensions of the web stiffened lipped channel beam sections were chosen such that they have almost equal distortional and global buckling stresses to have strong interactions. A validated numerical model was used to perform a parametric study and obtain design strength data for CFS web-stiffened lipped channel beams. Based on the obtained numerical data, an assessment of the current DSM equations and the equations proposed in the literature (for lipped channel CFS sections) is performed. Suitable modifications were also proposed in this work, which resulted in a higher level of design accuracy to predict the flexural strength of CFS web stiffened lipped channel beams undergoing distortional and global mode interaction. Furthermore, reliability analysis was performed to confirm the reliability of the proposed modification.
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