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RISS 인기검색어
- 검색키워드
- 저자 : Asashima, Makoto (검색결과 2 건)
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Cheong, S. W.,Fukui, A.,Asashima, M.,Pfeiffer, C. J. Institute of Genetic Engineering Changwon National 2000 Gene and Protein Vol.4 No.-
Teratomas are rare in amphibians and the neoplasm described here, which had a significant thyroid carcinoma component, is the first tumour of this type to be reported in Xemopus laevis. The thyroid component contained moderately to well-differentiated acinar glands showing much hyperplasia, dysplasia, and reduced and distorted colloid reservoirs. Cartilaginous, neural, muscular, meaenchymal and gut-like epithelial components were also observed in this ventral mediastinal neoplasm, indicating aberrant proliferation from all three germ layers. This teratoma was only one abnormality in a complex of developmental changes, followed for 28 months, which appeared in a single generation of sibling 2-weeks-old Xenopus larvae. Two hundred larvae produced by an apparently normal adult pair initially showed oculan defects, including microphthalmia, anophthalmia and tumours projecting near the eyes. During further development up to 28 month, mediastinal tumours developed in nine frogs; these tumours were associated with reduced growth, the frogs reaching only 13-20% of normal weight, and greatly enhanced ventral pigmentation.
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Fukuda, Masakazu,Takahashi, Shuji,Haramoto, Yoshikazu,Onuma, Yasuko,Kim, Yeon-Jin,Yeo, Chang-Yeol,Ishiura, Shoichi,Asashima, Makoto UPV/EHU Press 2010 The International journal of developmental biology Vol.54 No.1
<P>The T-box gene VegT plays a crucial role during mesendoderm specification of the amphibian embryo. While the function of maternal VegT (mVegT) has been extensively investigated, little is known about the function and transcriptional regulation of zygotic VegT (zVegT). In the present study, we used comparative genomics and a knockdown experiment to demonstrate that zVegT is the orthologous gene of zebrafish Spadetail/Tbx16 and chick Tbx6L/Tbx6, and has an essential role in paraxial mesodermal formation. zVegT knockdown embryos show several defects in the patterning of trunk mesoderm, such as abnormal segmentation of somites, a reduction in muscle, and the formation of an abnormal mass of cells at the tail tip. We also identified the cis-regulatory elements of zVegT that are necessary and sufficient for mesoderm-specific expression. These cis-regulatory elements are located in two separate upstream regions of zVegT, corresponding to the first intron of mVegT. The results of in vitro binding and functional assays indicate that Forkhead box H1 (FoxH1) and Eomesodermin (Eomes) are the trans-acting factors required for zVegT expression. Our results highlight the essential role of zVegT in organization of paraxial mesoderm, and reveal that zVegT is regulated by a coherent feedforward loop of Nodal signaling via Eomes.</P>
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