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RISS 인기검색어
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- 저자 : Alvaro Aguayo-Gonzalez (검색결과 1 건)
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Mixed-phenotype acute leukemia: suboptimal treatment when the 2008/2016 WHO classification is used
Alan Pomerantz,Sergio Rodriguez-Rodriguez,Roberta Demichelis-Gomez,Georgina Barrera-Lumbreras,Olga Barrales-Benitez,Xavier Lopez-Karpovitch,Alvaro Aguayo-Gonzalez 대한혈액학회 2016 Blood Research Vol.51 No.4
BackgroundDifferent criteria have been used to diagnose mixed-phenotype acute leukemia (MPAL), which has impacted the number of individuals diagnosed with this pathology. Better out-comes have been reported when using acute lymphoblastic leukemia (ALL)-type chemo-therapy in the treatment of MPAL.MethodsWe compared the outcome of 4 groups of patients with MPAL. Group 1 included patients diagnosed using the 2008/2016 World Health Organization (WHO) classification; group 2 included patients diagnosed using the European Group for the Immunological Characterization of Leukemias (EGIL) criteria; group 3 included patients diagnosed using either the EGIL or the 2008/2016 WHO criteria; and group 4 was comprised of patients diagnosed with MPAL using the EGIL classification only.ResultsWe found a significantly worse disease-free survival (groups 1‒4) and overall survival (OS) (groups 2 and 3) when comparing MPAL patients to other acute leukemia (AL) patients. A significantly better OS was obtained in patients (groups 2‒4) treated with ALL-type che-motherapy compared to acute myeloid leukemia (AML)-type regimens.ConclusionIn light of these results, and because a trend (P=0.06) was found with regard to a better OS in group 4 when compared to other AL patients, an argument can be made that the 2008/2016 WHO classification is underpowered to diagnose all MPAL cases, potentially resulting in the suboptimal treatment of some individuals with AL.
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