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RISS 인기검색어
- 검색키워드
- 저자 : Abd El-Magid, Afaf D (검색결과 3 건)
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Abd El Magid, Magda Ahmed,Elseed, Salah Mahmoud Hamed The Korean Society for Marine Biotechnology 2008 한국해양바이오학회지 Vol.3 No.1
Sudan is the largest country in Africa with an area of $2,505,810km^2$, of water constitutes $129,810km^2$, and cultivable land is 34%. Sudan has a total land boundary of 7,687 km with 9 border countries. This vast country embraces different vegetation patterns reflecting various climatic zones, grading from tropical rain forests in the south through semi-tropical savannah to arid zone in the extreme north, with annual rainfall ranging from 1,600 mm in the south to 25 mm in the north. The aquaculture industry is not developed as yet. Because of their basic characteristics, the Sudan inland and marine capture fisheries are of a small-scale and semi-industrial nature. The demand for fish and fish preparations is growing steadily. The animal resources sector (which includes fisheries) contributes 21% of Sudan GDP. The contribution of fisheries to Sudanese GDP is currently marginal. The per caput supply is only 1.6 kg/year, which is mostly obtained by capture fish landings. Despite the fact that fisheries GDP is extremely low, fish and fish preparations contribute to the food security of a wide sector of the rural and urban communities. Fisheries also provide work opportunities in the form of secondary employment as a source of income that indirectly contributes to household food security.
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Antitumoral and Antioxidant Potential of Egyptian Propolis Against the PC3 Prostate Cancer Cell Line
Salim, Elsayed I,Abd El-Magid, Afaf D,Farara, Khalid M,Maria, Dina SM Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17
It has been shown previously that nutritional supplements rich in polyphenolic compounds play a significant role in prostate cancer chemoprevention. Propolis is a natural, resinous hive product that has several pharmacological activities including antimicrobial, antioxidant, anti-inflammatory, and antitumoral activities. The aim of this study was to compare the cytotoxic, antioxidant and antitumoral activities of an ethanolic extract of Egyptian propolis (EEP) in vitro with an established chemotherapeutic drug such as doxorubicin (DOX), and the effects of their combination against the PC3 human prostate cancer cell line. Cellular viability and $IC_{50}$ levels with EEP, DOX and their (v/v) combination were detected by sulphorhodamine-B (SRB) assay after incubation of PC3 cells for 72h with different doses (0, 0.01, 0.1, 1, 10 and $100{\mu}g/ml$). Two selected doses of $IC_{50}$ and $IC_{25}$ were applied to cells for 24h for antitumor evaluation assay of treatment compounds. EEP and its (v/v) combination with DOX showed significant antitumor potential besides high antioxidant properties of superoxide dismutase (SOD), total antioxidant capacity (TAC), catalase (CAT), nitric oxide (NO) and reduced glutathione (GSH) levels when compared with the control untreated cells. DNA fragmentation assay and semi quantitative RT-PCR analyses for p53 and Bax genes showed that EEP activated cellular apoptosis and increased the mRNA expression levels more than other treatment. In conclusion, EEP alone or in combination with DOX at both doses used here showed greater antioxidant, antiproliferative and apoptotic effects against the PC3 cell lines as compared to treatment with DOX alone. Therefore, EEP could be considered as a promising candidate for prostate cancer chemotherapy.
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