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한국인 주요 우울장애환자에서 세로토닌 수송체 유전자 다형성
신준호 ( Jun Ho Shin ),백소영 ( So Young Baek ),정상근 ( Sang Keun Chung ),확익근 ( Ik Keun Hwang ) 전북대학교 의과학연구소 2004 全北醫大論文集 Vol.28 No.1
Objectives: There were many studies on serotonin transporter gene(5HTT), one of strong candidate genes related to depression. The results were controversial and even contradictory. The purpose of this study was to examine the relationship of the serotonin transporter gene and Korean major depressive disorder. Methods: The sample consisted of 58 Korean patients with major depressive disorder diagnosed according to DSM-IV criteria and 100 normal controls. They were genotyped at the serotonin transporter gene-linked polymorphic region (5HTTLPR) as s/s, s/1 1/1 genotypes. Results: There were no significant differences in genotypes between two groups(X2=4.490, df=2, p=0.106). There were no significant differences in allele frequency between two groups(X2=0.667, df=1, p=0.414). Conclusion: These results suggest that there is no association between polymorphism of the serotonin transporter gene and Korean major depressive disorder.