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모란 추출액에서 paeoniflorin과 paeonol 동시 정량 분석 및 화장품 원료의 품질관리 기준 설정
윤기훈(Ki Hun Yun),지용하(Yong Ha Chi),이동규(Dong Kyu Lee),백수희(Soo Heui Paik) 한국유화학회 2018 한국응용과학기술학회지 Vol.35 No.1
모란은 항염증작용, 항알레르기작용, 항균작용, 중추억제, 위액분비억제, 진경작용 등의 약리활 성이 있을 뿐 아니라 항산화작용, 미백작용 등이 보고되면서 화장품 원료, 미용식품으로 다양하게 활용 가능성이 탐색되고 있다. 모란의 뿌리, 잎 및 꽃에서 추출용매와 온도, 시간에 따른 추출액 중 성분의 함량 변화를 비교하였다. Paeoniflorin과 paeonol을 지표성분으로 하여 두 성분의 함량을 동시에 정량분석하기 위한 HPLC 분석법을 설정하고 분석 배치마다 검량선과 QC용 검체를 사용하여 시스템적합성을 확인하면서 시료 분석을 실시하였다. Paeonol은 뿌리에서만 검출되었고 잎과 꽃에서는 검출되지 않았으며, paeoniflorin은 잎, 꽃에서의 농도가 뿌리에서보다 높았다. 추출용매와 섞을 때 뿌리의 절도는 구입 당시의 조각을 그대로 사용할 때보다 적당한 크기로 분쇄한 후 사용할 때 두 성분 모두 높은 농도로 추출되었다. 추출용매로는 30% 1,3-butylene glycol을 사용할 때 농도가 가장 높았다. 추출온도와 시간은 고온, 장시간 일수록 농도가 높아지는 경향을 보였으나 75℃, 4 h 이상에서는 농도 상승이 완만했으며, paeonol은 8 h까지 지속적으로 농도가 상승하는 경향을 보였다. 뿌리, 잎, 꽃의 배합 비율은 2+2+1g/0.5kg로 할 때 두 지표성분의 함량 기준에 도달 가능하다고 판단하였다. 최종적으로 원재료를 2+2+1g/0.5kg로 배합하고 30% 1,3-butylene glycol을 추출용매로 사용하여 75℃에서 4 h 동안 추출하는 방법이 두 지표성분의 활성 농도 기준과 원재료 및 제조공정상의 비용을 함께 고려할 때 적절한 조건이라고 판단하였고, 이 조건에서 10 kg 규모까지 추출액 제조 단위를 스케일업 하였다. Paeony has pharmacological activities such as anti-inflammatory, anti-allergic, anti-bacterial, central inhibitory, gastric secretion inhibition, and antispasmodic activities. In addition, its antioxidant activity and whitening effect being reported, thus it is being explored as raw materials for cosmetics. We compared the changes in the contents of paeoniflorin and paeonol in Peony extracts, depending on the changes of extracting solvents, temperature and time. The HPLC method was set up for simultaneous analysis, the system suitabilities were confirmed by using the calibration curves and the QC samples for each assay batch. Paeonol was detected only in roots, and paeoniflorin was higher in leaf and flower than root. Higher concentrations of both ingredients were extracted when the root was used after grinding to a suitable size, and when 30% 1,3-butylene glycol was used as the extraction solvent. Also the concentrations tended to increase at higher temperature and longer time, but the increase was gradual at over 75℃ and 4 hours. The ratio of root, leaf and flower was determined to be 2+2+1g/0.5kg of batch, reaching the contents criteria of paeoniflorin and paeonol. Finally, we selected as the best extraction condition when the raw materials are mixed with 2+2+1g/0.5kg and extracted with 30% 1,3-butylene glycol as an extraction solvent at 75℃ for 4 hours, considering both the concentrations of two components and the cost of raw materials and manufacturing process, The extraction units were scaled up to 10 kg under this condition.
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말산클레보프리드 서방성 제제의 제조 및 약물동태학적 평가
류해원(Hae Won Ryou),이주한(Joo Han Lee),지용하(Yong Ha Chi),한양희(Yang Hee Hahn),단현광(Hyun Kwang Tan),이규흥(Kyu Heung Lee),김상린(Sang Lin Kim),전승윤(Seung Yoon Jeon),최영욱(Young Wook Choi) 한국약제학회 2000 Journal of Pharmaceutical Investigation Vol.30 No.3
Clebopride malate(Cm) is a new benzamide drug which has a potent central antidopaminergic activity possessing antiemetic and anxiolytic properties. A purpose of this study was to assess the feasibility of formulating sustained release preparation by dispersing a drug in hydrophilic polymeric matrices and double layered tablets(DLT), using HPMC, carbopol, PEO, PVP/VA and other polymers as a rate controlling barrier. The matrix and DLT showed optimum dissolution pattern up to 8 hours and the contents of polymer were optimized at 30% level in this preparation. After an oral administration in beagle dog, Cm concentration was determined by use of GC-ECD and pharmacokinetic parameters were calculated by Vallner`s method. The AUC of DLT showed similar results and the duration of action was increased 55% compared to that of regular release dosage form. The calculated absorption rate effectiveness(ARE) and controlled release effectiveness(CRE) for DLT increased 50% compared to that of matrix, the overall effectiveness(E) of this product appears to be about 70%. in vivo effectiveness test, DLT showed significant differences from control on antiemetic action of Cm. In consequence, it was possible to conclude that double layered tablet might be a good candidate for the sustained release dosage forms.
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池鏞夏 건국대학교 1965 學術誌 Vol.6 No.1
The moat important ways and means of rehabilitation of Korean devastated forest lands are on economizing lumber consumption and control of excessive cuttings. While the goverment reported that the felling volumes per year were 500,000-600,000 cubic meters, Naisan Report reported that additional 1,200,000 cubic meters of lumber more than the figure reported by the government were cut. The total quanties of demand for the lumber per year would amount over than 3,500,000 m3 because the estimated comsumption volumes of national lumbers amounted 643,424m3 in constructing buildings and houses in 1959. In order to economize the the lumbers and rehabilitate our devastated forest lands in the view point of lumber using buildings and houses, the following measure must be taken by the government. 1.To use as less lumbers as possible in constructing buildings and houses: 2.Te discontinue constructing Japanese building slyles which are tropical and not efficient to support heat. 3.To convert door and door frame lumber to steel sash. 4.To avoid using lumber at roofs and trusses and convert those to concreate slab. 5.To convert sheathing boards to plywoods; 6.To convert scaffold hoards to steel plates which are holed and used at the slide-way of aireraft. 7.To convert pile foundations to concrete piles. 8.To unify the height of ceilings in. order to extend the using period of supports fur concrete slab. (1965年 10月 3日)
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지용하 한국임학회 1963 한국산림과학회지 Vol.3 No.1
There are 3 kinds of forest managements: One of them is forest utilization management which collects abundant forest resources by felling the trees: the second of them is scientific forest management which cultivates forest resources; and the last one is emergency aid forest management, needed by the forest resources davastation, for the surposes of soil conservation and preventing the indirect damages. During the 36 years of Japanese occupation, they pillaged 600 to 800 million cubic meters of the forest resources, in the condition of the colonial system. After the emancipation from the Japanese occupation, the national soil conservation work has been practiced for 18 years without correcting the Japanese forest management (which means felling system) ; Therefore the essential in the forest, conservation works is to get rid of imitating the Japanese pillage management so as to turn the direction of the forestry policy to the emergency aid management which means forest investment.
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